{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:42:28Z","timestamp":1792194148762,"version":"4.4.0"},"reference-count":9,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Homeopathy"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The rubric \u201cAnger, consoled, when\u201d is described in several homeopathic repertories and materia medica sources, but its prognostic relevance has not been quantitatively examined. This study applied likelihood ratio (LR)-based prognostic factor research (PFR) to evaluate its real-world utility in individualized homeopathic practice, aiming to bridge traditional knowledge with evidence-based validation.<\/jats:p>\n                  <jats:p>This analytical epidemiological longitudinal study prospectively documented clinical outcomes in routine outpatient care at D. N. De Homoeopathic Medical College and Hospital, Kolkata, India. Adult patients receiving individualized homeopathic treatment were followed for 3 months. Clinical outcomes were assessed using the Outcome Related to Impact on Daily Living (ORIDL) scale, with scores\u2009\u2265\u2009+\u20092 indicating clinically meaningful improvement. Remedy-specific LR+ and LR\u2212\u2009with 95% confidence intervals (CIs) were calculated using 2\u2009\u00d7\u20092 contingency tables. LR+ indicates the certainty that the given medicine will work in the given condition; LR\u2212 indicates the relationship between a symptom and a medicine if the symptom is absent. In addition, phi (\u03a6) coefficient statistics were applied to quantify the strength and direction of symptom\u2013medicine associations, providing complementary effect-size information that enhanced interpretation of the prognostic relationships.<\/jats:p>\n                  <jats:p>From 1,740 screened patients, 1,699 (97.5%) completed follow-up (mean age: 42.3 years; 62% female). A total of 73 homeopathic medicines were prescribed. Chamomilla exhibited the highest prognostic rule-in value (LR+\u20092.0, 95% CI: 1.6 to 2.5), whereas Natrum muriaticum demonstrated the strongest symptom\u2013remedy association (\u03a6\u2009=\u20090.118). Moderate associations (LR+\u20091.5\u20131.9) occurred with Kalium iodatum, Natrum muriaticum, Arsenicum album, Natrum carbonicum, Sepia officinalis, and Staphysagria macrosperma. Phi analysis confirmed significant positive correlations (\u03a6\u2009=\u20090.12\u20130.18, p\u2009&lt;\u20090.01) for Natrum muriaticum, Chamomilla, Sepia officinalis and Arsenicum album; Causticum showed a negative association (\u03a6\u2009=\u2009\u2212\u20090.11, p\u2009=\u20090.03).<\/jats:p>\n                  <jats:p>The LR-PFR empirically validated rubric \u201cAnger, consoled, when\u201d, identifying Chamomilla as the prognostically strongest remedy, whereas Natrum muriaticum demonstrated the strongest statistical association with the rubric. Integrating phi into PFR enhanced the interpretation of association magnitude, thereby informing evidence-based repertory updates and clinical decision-making in homeopathy.<\/jats:p>","DOI":"10.1055\/a-2890-5821","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:17:15Z","timestamp":1792192635000},"source":"Crossref","is-referenced-by-count":0,"title":["Empirical Evaluation of the Repertory Rubric \u201cAnger, Consoled, when\u201d Using Likelihood Ratio-based Prognostic Factor Analysis in Individualized Homeopathic Practice"],"prefix":"10.1055","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0003-0678","authenticated-orcid":false,"given":"Deepanwita","family":"Bhattacharyya","sequence":"additional","affiliation":[{"name":"D. N. De Homoeopathic Medical College and Hospital, West Bengal, India","place":["Kolkata"],"department":["Department of Repertory, Affiliated to The West Bengal University of Health Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7587-7526","authenticated-orcid":false,"given":"Sk Monsur","family":"Alam","sequence":"additional","affiliation":[{"name":"D. N. De Homoeopathic Medical College and Hospital, West Bengal, India","place":["Kolkata"],"department":["Department of Repertory, Affiliated to The West Bengal University of Health Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0759-3448","authenticated-orcid":false,"given":"Rajat Kumar","family":"Pal","sequence":"additional","affiliation":[{"name":"D. N. De Homoeopathic Medical College and Hospital, West Bengal, India","place":["Kolkata"],"department":["Department of Repertory, Affiliated to The West Bengal University of Health Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2308-5265","authenticated-orcid":false,"given":"Subhranil","family":"Saha","sequence":"additional","affiliation":[{"name":"D. N. De Homoeopathic Medical College and Hospital, West Bengal, India","place":["Kolkata"],"department":["Department of Repertory, Affiliated to The West Bengal University of Health Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2521-2988","authenticated-orcid":false,"given":"Soumya","family":"Bhattacharyya","sequence":"additional","affiliation":[{"name":"D. N. De Homoeopathic Medical College and Hospital, West Bengal, India","place":["Kolkata"],"department":["Department of Materia Medica, Affiliated to The West Bengal University of Health Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4706-9692","authenticated-orcid":false,"given":"Munmun","family":"Koley","sequence":"additional","affiliation":[{"name":"East Bishnupur State Homoeopathic Dispensary, West Bengal, India","place":["South 24 Parganas"],"department":["Department of Health and Family Welfare"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3822-1043","authenticated-orcid":false,"given":"Shifa","family":"Hashmi","sequence":"additional","affiliation":[{"name":"D. N. De Homoeopathic Medical College and Hospital, West Bengal, India","place":["Kolkata"],"department":["Department of Repertory, Affiliated to The West Bengal University of Health Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5479-6413","authenticated-orcid":false,"given":"Tuhina","family":"Parveen","sequence":"additional","affiliation":[{"name":"D. N. De Homoeopathic Medical College and Hospital, West Bengal, India","place":["Kolkata"],"department":["Department of Repertory, Affiliated to The West Bengal University of Health Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7561-9800","authenticated-orcid":false,"given":"Shubhadeep","family":"Das","sequence":"additional","affiliation":[{"name":"D. N. De Homoeopathic Medical College and Hospital, West Bengal, India","place":["Kolkata"],"department":["Department of Repertory, Affiliated to The West Bengal University of Health Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1153-6706","authenticated-orcid":false,"given":"Quamar","family":"Sultana","sequence":"additional","affiliation":[{"name":"D. N. De Homoeopathic Medical College and Hospital, West Bengal, India","place":["Kolkata"],"department":["Department of Repertory, Affiliated to The West Bengal University of Health Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2017-006X","authenticated-orcid":false,"given":"Ashabul","family":"Mondal","sequence":"additional","affiliation":[{"name":"D. N. De Homoeopathic Medical College and Hospital, West Bengal, India","place":["Kolkata"],"department":["Department of Materia Medica, Affiliated to The West Bengal University of Health Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1139-6285","authenticated-orcid":false,"given":"Lex","family":"Rutten","sequence":"additional","affiliation":[{"name":"Independent Researcher, The Netherlands","place":["Breda"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,10,16]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1055\/s-0041-1725061","article-title":"Similia similibus curentur: theory, history, and status of the constitutive principle of homeopathy","volume":"110","author":"J M Schmidt","year":"2021","journal-title":"Homeopathy"},{"key":"ref2","first-page":"160","article-title":"Homeopathic remedies in COVID-19: prognostic factor research","volume":"110","author":"R K Manchanda","year":"2021","journal-title":"Homeopathy"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1055\/s-0041-1731314","article-title":"Impact of bias in the data collection of COVID-19 cases","volume":"111","author":"R K Manchanda","year":"2022","journal-title":"Homeopathy"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jasc.2020.09.008","article-title":"Evidence-based diagnostic accuracy measurement in urine cytology using likelihood ratios","volume":"10","author":"N Myles","year":"2021","journal-title":"J Am Soc Cytopathol"},{"key":"ref5","first-page":"60","article-title":"Prognostic factor research in homeopathy: overview of the method, with insights from condition-confined studies","volume":"115","author":"A Miglani","year":"2025","journal-title":"Homeopathy"},{"key":"ref6","volume-title":"Repertory of the Homoeopathic Materia Medica","author":"J T Kent","year":"2000","edition":"6th American ed"},{"key":"ref7","volume-title":"Homoeopathic Medical Repertory","author":"R Murphy","year":"2009","edition":"3rd ed."},{"key":"ref8","volume-title":"The Complete Repertory","author":"R Van Zandvoort","year":"2008","edition":"3rd ed."},{"key":"ref9","volume-title":"Synthesis: Repertorium Homeopathicum Syntheticum","author":"F Schroyens","year":"2001","edition":"9.1 ed."}],"container-title":["Homeopathy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2890-5821.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:17:18Z","timestamp":1792192638000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2890-5821"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,16]]},"references-count":9,"URL":"https:\/\/doi.org\/10.1055\/a-2890-5821","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1475-4916","1476-4245"],"issn-type":[{"value":"1475-4916","type":"print"},{"value":"1476-4245","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,16]]}}}