{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:54:01Z","timestamp":1791500041304,"version":"4.3.4"},"reference-count":10,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nuklearmedizin"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor that may express somatostatin receptors, enabling imaging with \u2076\u2078Ga-DOTATATE PET\/CT. Brain metastases from MTC are extremely rare, particularly in the absence of an identifiable primary tumor. We present a 63-year-old male with occult MTC and elevated serum calcitonin levels (27 pg\/mL). \u2076\u2078Ga-DOTATATE PET\/CT demonstrated focal tracer uptake in the right parietal lobe (SUVmax: 9.1), which was confirmed by brain MRI as a 7-mm enhancing lesion consistent with metastasis. This case highlights the value of \u2076\u2078Ga-DOTATATE PET\/CT in detecting unusual metastatic presentations in occult MTC.<\/jats:p>","DOI":"10.1055\/a-2892-1094","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T22:48:25Z","timestamp":1785192505000},"page":"321-322","source":"Crossref","is-referenced-by-count":0,"title":["Detection of Brain Metastasis in Occult Medullary Thyroid Carcinoma Using \u2076\u2078Ga-DOTATATE PET\/CT: A Case Report"],"prefix":"10.1055","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9287-7875","authenticated-orcid":false,"given":"Muhammet Halil","family":"Baltacioglu","sequence":"additional","affiliation":[{"name":"Trabzon University Faculty of Medicine, Turkey","place":["Trabzon"],"department":["Department of Nuclear Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1089\/thy.1998.8.517","article-title":"Medullary thyroid carcinoma: clinical features and long-term follow-up of seventy-eight patients treated between 1969 and 1986","volume":"8","author":"ME Girelli","year":"1998","journal-title":"Thyroid"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"4670","DOI":"10.3390\/cancers13184670","article-title":"Long-Term Outcomes and Causes of Death among Medullary Thyroid Carcinoma Patients with Distant Metastases","volume":"13","author":"H Park","year":"2021","journal-title":"Cancers"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1089\/thy.1999.9.1123","article-title":"Brain metastases from medullary thyroid carcinoma in a patient with multiple endocrine neoplasia type 2A","volume":"9","author":"SU Pitale","year":"1999","journal-title":"Thyroid"},{"key":"ref4","first-page":"448","article-title":"Brain metastases in patients with well-differentiated thyroid carcinoma: study of 11 cases","volume":"16","author":"S Venkatesh","year":"1990","journal-title":"Eur J Surg Oncol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s11060-008-9586-5","article-title":"Pituitary metastasis from medullary carcinoma of thyroid: case report and review of literature","volume":"89","author":"HS Bhatoe","year":"2008","journal-title":"J Neurooncol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/s0748-7983(95)91987-2","article-title":"Medullary cell carcinoma of the thyroid: metastases to the central nervous system","volume":"21","author":"CJ Kerawala","year":"1995","journal-title":"Eur J Surg Oncol"},{"key":"ref7","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijscr.2021.106419","article-title":"Choroidal metastasis as initial presentation of aggressive medullary thyroid carcinoma with widespread mediastinal, brain, pituitary, bone, lung, and liver metastasis: Case report and literature review","volume":"87","author":"M Hassan","year":"2021","journal-title":"Int J Surg Case Rep"},{"key":"ref8","first-page":"68","article-title":"Medullary thyroid carcinoma\u2014PET\/CT imaging with 68Ga-labelled gastrin and somatostatin analogues","volume":"67","author":"J Kunikowska","year":"2016","journal-title":"Endokrynol Pol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"362","DOI":"10.14310\/horm.2002.1756","article-title":"Detection rate of somatostatin receptor PET or PET\/CT in patients with recurrent medullary thyroid carcinoma: a systematic review and meta-analysis","volume":"16","author":"G Treglia","year":"2017","journal-title":"Hormones (Athens)"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1097\/RLU.0000000000002163","article-title":"Brain metastasis of medullary thyroid carcinoma without macroscopic calcification detected first on 68GaDOTATATE and then on 18F-fluoride PET\/CT","volume":"43","author":"PS Duarte","year":"2018","journal-title":"Clin Nucl Med"}],"container-title":["Nuklearmedizin - NuclearMedicine"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2892-1094.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:31:45Z","timestamp":1791498705000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2892-1094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,27]]},"references-count":10,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2026,10,8]]},"published-print":{"date-parts":[[2026,10]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2892-1094","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0029-5566","2567-6407"],"issn-type":[{"value":"0029-5566","type":"print"},{"value":"2567-6407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,27]]}}}