{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:51:32Z","timestamp":1791589892043,"version":"4.3.4"},"reference-count":75,"publisher":"Georg Thieme Verlag KG","issue":"05","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":8,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg K Kleintiere Heimtiere"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Bei der routinem\u00e4\u00dfigen Bestimmung von Thyroxin (T4) bei Hunden werden h\u00e4ufig Gesamt-Thyroxin-Werte (TT4) unterhalb des Referenzbereichs festgestellt, die neben einer Hypothyreose auch in einer nicht schilddr\u00fcsenbedingten Erkrankung (Non-Thyroidal Illness Syndrome, NTIS) begr\u00fcndet sein k\u00f6nnen. Ziel dieser Studie war es, TT4-, freies T4 (fT4)-, schilddr\u00fcsenstimulierendes Hormon (TSH)-, Gesamt-Triiodthyronin (TT3)-Konzentrationen sowie Thyreoglobulin-Autoantik\u00f6rper (TgAA) bei Hunden mit NTIS systematisch zu untersuchen und mit gesunden sowie hypothyreoten Hunde zu vergleichen.<\/jats:p>\n                  <jats:p>In dieser retrospektiven Querschnittsstudie wurden Daten aus einer medizinischen Datenbank sowie 272 Restserumproben von Hunden analysiert, die zwischen Mai 2021 und M\u00e4rz 2023 an der Kleintierklinik der Stiftung Tier\u00e4rztliche Hochschule Hannover vorgestellt wurden. Neben 40 gesunden Hunden wurden insgesamt 463 Diagnosen von 232 Hunden erfasst und kategorisiert. In der NTIS-Teilstichprobe wurden multiple lineare Regressionsanalysen unter Ber\u00fccksichtigung von Alter und Erkrankungskategorien durchgef\u00fchrt. Zus\u00e4tzlich erfolgten Kovarianzanalysen zu entz\u00fcndlichen Erkrankungen, Multimorbidit\u00e4t und station\u00e4rer Behandlung. Die \u00dcbereinstimmung von TT4 und fT4 wurde mittels Spearman-Korrelation und Bland-Altman-Analyse gepr\u00fcft.<\/jats:p>\n                  <jats:p>37 Hunden wurden als hypothyreot diagnostiziert. In der NTIS-Gruppe dominierten neurologische (n=125), gastrointestinale (n=63), urogenitale (n=33), kardiale (n=32) und onkologische Erkrankungen (n=31). Innerhalb von 3 Monaten verstarben 6,6% der NTIS-Hunde. Niedrigere TT4- und TT3-Werte waren signifikant mit gastrointestinalen Erkrankungen, station\u00e4rer Behandlung, mehr als 3 Komorbidit\u00e4ten und entz\u00fcndlichen Erkrankungen assoziiert, fT4 hingegen nicht. TT4 und fT4 waren bei Hunden mit NTIS und Hypothyreose im Vergleich zu gesunden Hunden signifikant reduziert. Gesunde Hunde wiesen signifikant niedrigere logarithmierte TSH-Werte (log[TSH]) auf als Hunde mit Hypothyreose und signifikant h\u00f6here log(TSH)-Werte als Hunde mit NTIS. Zudem lagen die log(TSH)-Werte bei Hunden mit Hypothyreose signifikant \u00fcber denen der NTIS-Hunde. F\u00fcr TT3 ergab der Gruppenvergleich keine Signifikanz.<\/jats:p>\n                  <jats:p>Hunde mit NTIS zeigen signifikant niedrigere TT4- und fT4-Werte als gesunde Hunde. TSH-Konzentrationen sind bei Hunden mit NTIS signifikant niedriger als bei hypothyreoten und gesunden Hunden. Zus\u00e4tzlich haben verschiedene Erkrankungen einen unterschiedlich starken Einfluss auf die Schilddr\u00fcsenparameter.<\/jats:p>\n                  <jats:p>Die alleinige Bestimmung von TT4 und fT4 reicht zur Diagnose einer Hypothyreose nicht aus, da NTIS vergleichbare Ver\u00e4nderungen verursachen kann. Der sichere Ausschluss anderer Erkrankungen ist f\u00fcr die Interpretation der Schilddr\u00fcsenhormonkonzentrationen essenziell.<\/jats:p>","DOI":"10.1055\/a-2894-2124","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:21:38Z","timestamp":1791588098000},"page":"304-314","source":"Crossref","is-referenced-by-count":0,"title":["Schilddr\u00fcsenhormon-Profile bei euthyreoten, hypothyreoten Hunden und Hunden mit definiertem Non-thyroidal Illness Syndrome"],"prefix":"10.1055","volume":"54","author":[{"given":"Judith","family":"Freudenberg","sequence":"additional","affiliation":[{"name":"Klinisch-Endokrinologisches Labor, Stiftung Tier\u00e4rztliche Hochschule Hannover"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"Schnelten","sequence":"additional","affiliation":[{"name":"Klinisch-Endokrinologisches Labor, Stiftung Tier\u00e4rztliche Hochschule Hannover"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Volk","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kleintiere, Stiftung Tier\u00e4rztliche Hochschule Hannover"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Rieder","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kleintiere, Stiftung Tier\u00e4rztliche Hochschule Hannover"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Schmicke","sequence":"additional","affiliation":[{"name":"Klinisch-Endokrinologisches Labor, Stiftung Tier\u00e4rztliche Hochschule Hannover"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1111\/jvim.17059","article-title":"Total thyroxine, triiodothyronine, and thyrotropin concentrations during acute nonthyroidal 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