{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T23:24:24Z","timestamp":1787268264498,"version":"build-2736575974"},"reference-count":123,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg G Grosstiere Nutztiere"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Neugeborenendurchfall stellt weltweit nicht nur die h\u00e4ufigste, sondern auch eine der verlustreichsten Erkrankungen junger K\u00e4lber dar. Klinisch relevante Folgeerscheinungen ergeben sich bei erkrankten K\u00e4lbern ma\u00dfgeblich durch die eintretenden Fl\u00fcssigkeitsverluste mit konsekutiver Dehydratation sowie durch die Entstehung einer metabolischen Azidose und damit assoziierten St\u00f6rungen des Kaliumhaushalts. Metabolische Azidosen entstehen bei K\u00e4lbern mit Neugeborenendurchfall vorwiegend durch Akkumulation starker Anionen, insbesondere von D-Laktat, infolge bakterieller Fermentationsprozesse unverdauter Nahrungsbestandteile im Gastrointestinaltrakt. Erh\u00f6hte D-Laktatkonzentrationen im Blut der K\u00e4lber leisten nicht nur einen wesentlichen Beitrag zur Entstehung metabolischer Azidosen, sondern sind auch f\u00fcr eine Vielzahl der klinischen Erscheinungen wie Depression, Schw\u00e4che, Einschr\u00e4nkungen des Stehverm\u00f6gens und einer Beeintr\u00e4chtigung des Lidreflexes verantwortlich.<\/jats:p>\n                  <jats:p>Hyperkali\u00e4mien treten trotz negativer Kaliumbilanz bei bis zu einem Drittel der schwer an Neugeborenendurchfall erkrankten K\u00e4lbern auf und stehen im Zusammenhang mit Dehydratation, eingeschr\u00e4nkter Nierenfunktion sowie der Art der metabolischen Azidose. W\u00e4hrend D-Laktatazidosen selten mit einer Hyperkali\u00e4mie assoziiert sind, gehen Hyperkali\u00e4mien typischerweise mit schwerer Exsikkose, Muskelschw\u00e4che und kardialen Reizleitungsst\u00f6rungen einher und sind als potenziell lebensbedrohlicher Notfall zu werten.<\/jats:p>\n                  <jats:p>Die vorliegende \u00dcbersicht fasst aktuelle pathophysiologische Erkenntnisse zu diesen zentralen Stoffwechselst\u00f6rungen bei K\u00e4lbern mit Neugeborenendurchfall zusammen und verdeutlicht deren klinische Relevanz f\u00fcr Diagnostik und Therapie.<\/jats:p>","DOI":"10.1055\/a-2894-3327","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T22:42:13Z","timestamp":1787265733000},"page":"272-283","source":"Crossref","is-referenced-by-count":0,"title":["St\u00f6rungen des S\u00e4ure-Basen- und Kaliumhaushalts bei K\u00e4lbern mit Neugeborenendurchfall"],"prefix":"10.1055","volume":"54","author":[{"given":"Florian 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