{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T23:27:59Z","timestamp":1786663679543,"version":"build-2736575974"},"reference-count":45,"publisher":"Georg Thieme Verlag KG","funder":[{"DOI":"10.13039\/100014717","name":"National Outstanding Youth Science Fund Project of National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82504909"],"award-info":[{"award-number":["82504909"]}],"id":[{"id":"10.13039\/100014717","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100014717","name":"National Outstanding Youth Science Fund Project of National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82574490"],"award-info":[{"award-number":["82574490"]}],"id":[{"id":"10.13039\/100014717","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Guangdong Basic and Applied Basic Research Foundation","award":["2026A1515010643"],"award-info":[{"award-number":["2026A1515010643"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Allergic rhinitis is a prevalent chronic inflammatory disorder of the nasal mucosa, imposing substantial medical and socioeconomic burdens. Thus, there is an urgent need to develop novel agents capable of both symptom relief and immune modulation. This study elucidates the mechanism by which tetrandrine alleviates allergic rhinitis through REV-ERB\u03b1 activation and cholinergic pathway suppression. In ovalbumin-induced allergic rhinitis mice, intranasal tetrandrine significantly reduced sneezing frequency and nasal scratching versus controls, while decreasing serum histamine and substance P levels. Mechanistically, tetrandrine dose-dependently upregulated the mRNA and protein expression of REV-ERB\u03b1 in nasal mucosa, enhancing its transcriptional repression in Gal4 reporter assays. Genetic ablation of Rev-erb\u03b1 abolished tetrandrine\u02bcs efficacy, exacerbating allergic rhinitis symptoms and inflammatory mediators. Crucially, tetrandrine suppressed choline acetyltransferase expression in nasal mucosa, reducing the level of acetylcholine; this effect was diminished by \u03b1-NETA (choline acetyltransferase inhibitor) pretreatment. This confirmed the essential role of REV-ERB\u03b1-dependent suppression of choline acetyltransferase\u2013mediated acetylcholine synthesis in tetrandrine\u02bcs therapeutic effect on allergic rhinitis. These findings establish tetrandrine as a novel agent targeting the circadian clock pathway and the circadian-allergy crosstalk, providing a new therapeutic strategy for allergic rhinitis.<\/jats:p>","DOI":"10.1055\/a-2896-7569","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T22:54:51Z","timestamp":1786661691000},"source":"Crossref","is-referenced-by-count":0,"title":["Tetrandrine Alleviates Allergic Rhinitis via REV-ERB\u03b1-Dependent Acetylcholine"],"prefix":"10.1055","author":[{"given":"Luomin","family":"Lin","sequence":"first","affiliation":[{"name":"Institute of Molecular Rhythm and Metabolism, Guangzhou University of Chinese Medicine, Guangzhou, China"},{"name":"Dongguan Institute of Guangzhou University of Chinese Medicine, Dongguan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingying","family":"Hao","sequence":"first","affiliation":[{"name":"Institute of Molecular Rhythm and Metabolism, Guangzhou University of Chinese Medicine, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Liu","sequence":"additional","affiliation":[{"name":"Engineering Center of Catalysis and Synthesis for Chiral Molecules, State Key Laboratory of Molecular Engineering of Polymers, Department of Chemistry, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiman","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Molecular Rhythm and Metabolism, Guangzhou University of Chinese Medicine, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3689-4913","authenticated-orcid":false,"given":"Dong","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/wjo2.70035","article-title":"Current insights into individualized diagnosis and treatment of allergic rhinitis based on phenotype and endotype","volume":"12","author":"Y Gu","year":"2025","journal-title":"World J Otorhinolaryngol Head Neck Surg"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s13223-024-00923-6","article-title":"Allergic rhinitis","volume":"20","author":"L Rosenfield","year":"2024","journal-title":"Allergy Asthma Clin Immunol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1365-2222.2011.03891.x","article-title":"Prevalence and diversity of allergic rhinitis in regions of the world beyond Europe and North America","volume":"42","author":"C H Katelaris","year":"2012","journal-title":"Clin Exp Allergy"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"23","DOI":"10.53529\/2500-1175-2023-3-23-33","article-title":"Frequency of non-asthma-like symptoms of allergic diseases based on ISAAC results in adolescents of the Khabarovsk region, Russia","volume":"3","author":"E N Suprun","year":"2023","journal-title":"Allergol Immunol Paediatr"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"S52","DOI":"10.2500\/ajra.2013.27.3928","article-title":"Chapter 15: Allergic rhinitis","volume":"27","author":"R A Settipane","year":"2013","journal-title":"Am J Rhinol Allergy"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13223-018-0280-7","article-title":"Allergic rhinitis","volume":"14","author":"P Small","year":"2018","journal-title":"Allergy Asthma Clin Immunol"},{"key":"ref7","first-page":"41","article-title":"Efficacy and safety of monotherapy versus combination therapy in treatment of allergic rhinitis: A Meta-analysis","volume":"33","author":"J Li","year":"2019","journal-title":"Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13223-018-0314-1","article-title":"The complex pathophysiology of allergic rhinitis: scientific rationale for the development of an alternative treatment option","volume":"15","author":"L Bjermer","year":"2019","journal-title":"Allergy Asthma Clin Immunol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s11101-020-09673-w","article-title":"A critical review: traditional uses, phytochemistry, pharmacology and toxicology of Stephania tetrandra S. 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