{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:15:53Z","timestamp":1783556153287,"version":"3.55.0"},"reference-count":22,"publisher":"Georg Thieme Verlag KG","issue":"CP","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background Endoscopic vacuum therapy (EVT) is a minimally invasive therapy for managing transmural gastrointestinal defects and supports the control of local infection. The role of EVT in patients with infected walled-off necrosis (WON) resulting from acute necrotizing pancreatitis (ANP) has not yet been investigated.<\/jats:p>\n                  <jats:p>Methods A multicenter retrospective case analysis was conducted. Patients with infected WON due to severe ANP (Revised Atlanta Classification) in whom the standard step-up therapy was expanded to include EVT, were identified and included in the study.<\/jats:p>\n                  <jats:p>Results Sixteen patients (aged 22\u201381 years) were treated in addition to standard therapy with EVT in four tertiary care centers in Germany and Brazil. After a total of 108 EVT device exchanges, the clinical success (sepsis control, complete resolution of WON, and closure of fistula) was achieved in 14 of 16 patients. Two patients died as a direct result of ANP and WON, while one further patient died of pneumosepsis after complete resolution of WON.<\/jats:p>\n                  <jats:p>Intracavitary bleeding occurred during device exchange in two patients, corresponding to a per-procedure bleeding rate of 1.9%.<\/jats:p>\n                  <jats:p>Conclusions Intracavitary EVT is feasible and relatively safe in treating patients with WON. Larger prospective trials are necessary to evaluate a potential adjunctive benefit of EVT in this challenging patient cohort.<\/jats:p>","DOI":"10.1055\/a-2897-6337","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T22:49:55Z","timestamp":1781822995000},"source":"Crossref","is-referenced-by-count":0,"special_numbering":"S","title":["Feasibility and Safety of Endoscopic Vacuum Therapy of Walled-Off Necrosis in Acute Necrotizing Pancreatitis"],"prefix":"10.1055","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2548-1749","authenticated-orcid":false,"given":"Peter","family":"Ewald","sequence":"additional","affiliation":[{"name":"Katholisches Klinikum Bochum Sankt Josef-Hospital, Nordrhein-Westfalen, Germany","place":["Bochum"],"department":["Department of Medicine and Gastroenterology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Cahyadi","sequence":"additional","affiliation":[{"name":"Katholisches Klinikum Bochum Sankt Josef-Hospital, Nordrhein-Westfalen, Germany","place":["Bochum"],"department":["Department of Medicine and Gastroenterology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Zeidler","sequence":"additional","affiliation":[{"name":"Katholisches Klinikum Bochum Sankt Josef-Hospital, Nordrhein-Westfalen, Germany","place":["Bochum"],"department":["Department of Medicine and Gastroenterology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Tophof","sequence":"additional","affiliation":[{"name":"Katholisches Klinikum Bochum Sankt Josef-Hospital, Nordrhein-Westfalen, Germany","place":["Bochum"],"department":["Department of Medicine and Gastroenterology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mousa","family":"Ayoub","sequence":"additional","affiliation":[{"name":"Katholisches Klinikum Bochum Sankt Josef-Hospital, Nordrhein-Westfalen, Germany","place":["Bochum"],"department":["Department of Medicine and Gastroenterology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2255-7032","authenticated-orcid":false,"given":"Markus W.","family":"Scheppach","sequence":"additional","affiliation":[{"name":"University Hospital Augsburg, Bayern, Germany","place":["Augsburg"],"department":["Department of Gastroenterology (III. Med. Klinik)"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Nagl","sequence":"additional","affiliation":[{"name":"University Hospital Augsburg, Bayern, Germany","place":["Augsburg"],"department":["Department of Gastroenterology (III. Med. Klinik)"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Wedemeyer","sequence":"additional","affiliation":[{"name":"Robert-Koch-Hospital Gehrden, Niedersachsen, Germany","place":["Gehrden"],"department":["Department of Internal Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7446-0355","authenticated-orcid":false,"given":"Diogo T. H.","family":"de Moura","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo, S\u00e3o Paulo, Brazil","place":["S\u00e3o Paulo"],"department":["Gastrointestinal Endoscopy Unit"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8023-3722","authenticated-orcid":false,"given":"Eduardo G. H.","family":"de Moura","sequence":"additional","affiliation":[{"name":"Universidade de Sao Paulo Hospital das Clinicas, Brazil","place":["Sao Paulo"],"department":["Gastrointestinal Endoscopy Department"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Messmann","sequence":"additional","affiliation":[{"name":"University Hospital Augsburg, Bayern, Germany","place":["Augsburg"],"department":["Department of Gastroenterology (III. Med. 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