{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T23:02:47Z","timestamp":1789772567472,"version":"4.0.1"},"reference-count":41,"publisher":"Georg Thieme Verlag KG","issue":"07","funder":[{"name":"National Key Research and\nDevelopment Program of China","award":["2020YFC2008305"],"award-info":[{"award-number":["2020YFC2008305"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Res (Stuttg)"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Heart failure is a significant global health burden. This study aims to\nidentify heart failure\u2013associated genes through transcriptome-wide\nassociation studies combined with genome-wide association studies.<\/jats:p>\n                  <jats:p>A transcriptome-wide association study was conducted using Functional\nSummary-based Imputation, integrating heart failure genome-wide association\nstudy summary data (47,309 cases and 930,014 controls) with Genotype-Tissues\nExpression Project V8 expression quantitative trait loci data from 49\ntissues. Gene-level analysis was performed using Multi-marker Analysis of\nGenomic Annotation, followed by mendelian randomization and Bayesian\ncolocalization. The functional implications of candidate genes were explored\nusing GeneMANIA, and the druggability of the top gene, USP36, was\nevaluated via molecular docking simulations.<\/jats:p>\n                  <jats:p>Functional Summary-based Imputation and Multi-marker Analysis of Genomic\nAnnotation analyses identified 26 candidate genes. Further investigation\nhighlighted USP36 as significant, particularly in left ventricular\ntissue, where it confers protection against heart failure. GeneMANIA showed\nthat USP36 interacts with genes involved in oxidative stress-induced\napoptosis, suggesting its role in heart failure pathogenesis. Molecular\ndocking simulations confirmed USP36\u2019s binding affinity with heart failure\ntherapeutics, supporting its potential as a therapeutic target.<\/jats:p>\n                  <jats:p>USP36 is a novel heart failure susceptibility gene and a promising\ntherapeutic target. Its involvement in oxidative stress-related pathways\noffers new insights into heart failure risk and warrants further\ninvestigation for disease development and treatment.<\/jats:p>","DOI":"10.1055\/a-2897-9774","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:03:10Z","timestamp":1787007790000},"page":"186-194","source":"Crossref","is-referenced-by-count":0,"title":["A Novel Transcriptome-Wide Association Study Identifies USP36\nas a Potential Therapeutic Target for Heart Failure"],"prefix":"10.1055","volume":"76","author":[{"given":"Kefu","family":"Yu","sequence":"additional","affiliation":[{"name":"Fengtai District, China","place":["Beijing"],"department":["Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9796-5785","authenticated-orcid":false,"given":"Qiuxiao","family":"Meng","sequence":"additional","affiliation":[{"name":"Capital Medical University, China","place":["Beijing"],"department":["College of Pharmacy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenshuo","family":"Jiang","sequence":"additional","affiliation":[{"name":"Fengtai District, China","place":["Beijing"],"department":["Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0281-2259","authenticated-orcid":false,"given":"Zhigang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Fengtai District, China","place":["Beijing"],"department":["Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8582-5110","authenticated-orcid":false,"given":"Li","family":"Yang","sequence":"additional","affiliation":[{"name":"Fengtai District, China","place":["Beijing"],"department":["Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1093\/cvr\/cvad100","article-title":"Cardiac lipid metabolism, mitochondrial function, and heart failure","volume":"119","author":"L Da Dalt","year":"2023","journal-title":"Cardiovasc Res"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e13642","DOI":"10.1111\/apha.13642","article-title":"Cognitive impairment in myocardial infarction and heart failure","volume":"232","author":"K 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Niu","year":"2024","journal-title":"Biomolecules"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1038\/s41419-022-05474-5","article-title":"USP36 facilitates esophageal squamous carcinoma progression via stabilizing\nYAP","volume":"13","author":"W Zhang","year":"2022","journal-title":"Cell Death Dis"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1186\/s13046-024-03160-2","article-title":"USP36 promotes tumorigenesis and tamoxifen resistance in breast cancer by\ndeubiquitinating and stabilizing ER\u03b1","volume":"43","author":"T Zhuang","year":"2024","journal-title":"J Exp Clin Cancer Res"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.bbrc.2019.03.043","article-title":"USP36 protects proximal tubule cells from ischemic injury by stabilizing c-Myc\nand SOD2","volume":"513","author":"Q Liu","year":"2019","journal-title":"Biochem Biophys Res Commun"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.3390\/ijms21082661","article-title":"Effects of oxidative stress on protein translation: Implications for\ncardiovascular diseases","volume":"21","author":"A Ghosh","year":"2020","journal-title":"Int J Mol Sci"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"9829505","DOI":"10.1155\/2022\/9829505","article-title":"Oxidative stress and heart failure: Mechanisms, signalling\npathways, and therapeutics","volume":"2022","author":"L U Pagan","year":"2022","journal-title":"Oxid Med Cell\nLongev"}],"container-title":["Drug Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2897-9774.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T22:32:32Z","timestamp":1789770752000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2897-9774"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,17]]},"references-count":41,"journal-issue":{"issue":"07","published-online":{"date-parts":[[2026,9,18]]},"published-print":{"date-parts":[[2026,9]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2897-9774","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2194-9379","2194-9387"],"issn-type":[{"value":"2194-9379","type":"print"},{"value":"2194-9387","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,17]]}}}