{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T23:20:25Z","timestamp":1783466425126,"version":"3.55.0"},"reference-count":21,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Sports Med"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Monitoring internal physiological responses in elite soccer players remains\n                    challenging due to the limitations of subjective scales and nonspecific\n                    biomarkers. This study examined whether leukocyte morphology and endothelial\n                    stress markers respond to acute exercise and a 6-week preseason training program\n                    in elite soccer players and explored their potential utility for objective\n                    athlete monitoring. Twenty-two male outfield players were assessed at baseline\n                    (48 h pre\u2013preseason), immediately after a maximal Yo\u2013Yo intermittent running\n                    test, and 72 hours after the preseason period. Leukocyte volume, conductivity,\n                    and scatter, factor VIII, von Willebrand factor, inflammatory, and metabolic\n                    markers were measured. Principal component analysis and K-means clustering\n                    explored morphological response patterns. Acute exercise increased white blood\n                    cells (+29%), neutrophils (+47%), platelets (+15%), factor VIII (+102%), and von\n                    Willebrand factor (+80%; all p&lt;0.003) without changes in volume,\n                    conductivity, and scatter parameters. After 6 weeks, the lymphocyte volume,\n                    conductivity, and scatter and neutrophil conductivity and scatter decreased\n                    significantly (all p&lt;0.0042), whereas leukocyte counts remained\n                    unchanged. Cluster analysis identified two morphological response patterns.\n                    These findings indicate phase-specific leukocyte morphological and endothelial\n                    responses to acute and chronic training and suggest that automated hematology\n                    markers may detect subclinical physiological adaptations not captured by\n                    conventional indices.<\/jats:p>","DOI":"10.1055\/a-2899-8817","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T22:32:37Z","timestamp":1783463557000},"source":"Crossref","is-referenced-by-count":0,"title":["Leukocyte Morphology Changes during Preseason in Elite Soccer\n                    Players: A Pilot Study"],"prefix":"10.1055","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8842-2360","authenticated-orcid":false,"given":"Nikolaos","family":"Androulakis","sequence":"additional","affiliation":[{"name":"University General Hospital of Heraklion Medical\n                    Service, Greece","place":["Heraklion"],"department":["Hematology Lab"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Nioti","sequence":"additional","affiliation":[{"name":"University General Hospital of Heraklion Medical\n                    Service, Greece","place":["Heraklion"],"department":["Hematology laboratory"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonios","family":"Dilintas","sequence":"additional","affiliation":[{"name":"University General Hospital of Heraklion Medical\n                    Service, Greece","place":["Heraklion"],"department":["Hematology laboratory"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Papadopoulou","sequence":"additional","affiliation":[{"name":"University General Hospital of Heraklion Medical\n                    Service, Greece","place":["Heraklion"],"department":["Hematology laboratory"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Striligka","sequence":"additional","affiliation":[{"name":"University General Hospital of Heraklion Medical\n                    Service, Greece","place":["Heraklion"],"department":["Hematology laboratory"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fotini","family":"Nistikaki","sequence":"additional","affiliation":[{"name":"University General Hospital of Heraklion Medical\n                    Service, Greece","place":["Heraklion"],"department":["Hematology laboratory"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodosia","family":"Iatridi","sequence":"additional","affiliation":[{"name":"University General Hospital of Heraklion Medical\n                    Service, Greece","place":["Heraklion"],"department":["Hematology laboratory"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Kalpadakis","sequence":"additional","affiliation":[{"name":"University General Hospital of Heraklion Medical\n                    Service, Greece","place":["Heraklion"],"department":["Hematology laboratory"]},{"name":"University of Crete School of Medicine, Greece","place":["Heraklion"],"department":["Hematology"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,7,7]]},"reference":[{"issue":"06","key":"ref1","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1080\/02640410400021278","article-title":"Physiol assess aerobic training in soccer","volume":"23","author":"F M Impellizzeri","year":"2005","journal-title":"J Sports Sci"},{"issue":"01","key":"ref2","first-page":"109","article-title":"A new approach to monitoring exercise training","volume":"15","author":"C Foster","year":"2001","journal-title":"J Strength Cond 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