{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T23:08:10Z","timestamp":1789600090232,"version":"build-2803163510"},"reference-count":18,"publisher":"Georg Thieme Verlag KG","issue":"09","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geburtshilfe Frauenheilkd"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Non-invasive prenatal testing (NIPT) may incidentally reveal chromosomal abnormalities of maternal origin. Although specific chromosomal aberrations have been associated with maternal malignancy, reported risks vary widely. This meta-analysis aimed to quantify the magnitude and consistency of these associations.<\/jats:p>\n                  <jats:p>A systematic review and meta-analysis of observational studies reporting maternal malignancy among pregnant individuals with abnormal NIPT results was conducted. Odds ratios (ORs) with 95% confidence intervals (CIs) were pooled using a random-effects model. Risk of bias was assessed using the ROBINS-I tool.<\/jats:p>\n                  <jats:p>Six studies met the inclusion criteria. Multiple chromosomal aberrations (MCA), although representing a minority of abnormal NIPT findings, accounted for a substantial proportion of confirmed maternal malignancies. MCA were strongly associated with cancer (OR 239.98; 95% CI 80.16\u2013718.44; I2 =\u00a00%). In studies that further characterized genomic patterns, complex gain\u2013loss profiles were also associated with increased risk (OR 188.64; 95% CI 34.17\u20131041.51; I2 =\u00a09.5%). Heterogeneity was low across analyses.<\/jats:p>\n                  <jats:p>Multiple chromosomal aberrations and complex gain\u2013loss patterns on NIPT were strongly associated with maternal malignancy. These findings support the use of structured diagnostic pathways and targeted clinical evaluation when high-risk genomic patterns are identified.<\/jats:p>","DOI":"10.1055\/a-2900-2752","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T22:40:21Z","timestamp":1783636821000},"page":"808-815","source":"Crossref","is-referenced-by-count":0,"title":["Maternal Malignancies Identified Through Non-invasive Prenatal Testing: A Systematic Review and Meta-Analysis"],"prefix":"10.1055","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3004-1087","authenticated-orcid":false,"given":"Eduardo","family":"Teixeira","sequence":"additional","affiliation":[{"name":"University of Vassouras (Univassouras), RJ, Brazil","place":["Vassouras"],"department":["Department of Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6694-6569","authenticated-orcid":false,"given":"Gustavo Yano","family":"Callado","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein, SP, Brazil","place":["S\u00e3o Paulo"],"department":["Faculdade Israelita de Ci\u00eancias da Sa\u00fade Albert Einstein"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5827-9927","authenticated-orcid":false,"given":"Daryane","family":"Rezzuto","sequence":"additional","affiliation":[{"name":"Amazonas State University (UEA), AM, Brazil","place":["Manaus"],"department":["Department of Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9744-7268","authenticated-orcid":false,"given":"Carolina Josu\u00e9 Vilella Waideman","family":"Puga","sequence":"additional","affiliation":[{"name":"The City University of S\u00e3o Paulo (UNICID), SP, Brazil","place":["S\u00e3o Paulo"],"department":["Department of Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6376-0305","authenticated-orcid":false,"given":"Henrique","family":"Provinciatto","sequence":"additional","affiliation":[{"name":"Bar\u00e3o de Maua University Center, SP, Brazil","place":["Ribeir\u00e3o Preto"],"department":["Department of Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2942-6182","authenticated-orcid":false,"given":"Antonio","family":"Braga","sequence":"additional","affiliation":[{"name":"University of Vassouras (Univassouras), RJ, Brazil","place":["Vassouras"],"department":["Department of Medicine"]},{"name":"Federal University of the State of Rio de Janeiro (UNIRIO), RJ, Brazil","place":["Rio de Janeiro"],"department":["Department of General and Specialized Surgery, School of Medicine and Surgery"]},{"name":"Federal University of Rio de Janeiro (UFRJ), RJ, Brazil","place":["Rio de Janeiro"],"department":["Department of Gynecology and Obstetrics, School of Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2620-7486","authenticated-orcid":false,"given":"Gabriele","family":"Tonni","sequence":"additional","affiliation":[{"name":"Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), AUSL Reggio Emilia, Italy","place":["Reggio Emilia"],"department":["Prenatal Diagnostic Center, Department of Obstetrics and Neonatology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6145-2532","authenticated-orcid":false,"given":"Edward","family":"Araujo J\u00fanior","sequence":"additional","affiliation":[{"name":"Paulista School of Medicine \u2013 Federal University of S\u00e3o Paulo (EPM-UNIFESP), SP, Brazil","place":["S\u00e3o Paulo"],"department":["Department of Obstetrics"]},{"name":"Municipal University of S\u00e3o Caetano do Sul (USCS), SP, Brazil","place":["S\u00e3o 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