{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T23:25:44Z","timestamp":1787181944899,"version":"build-2736575974"},"reference-count":56,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Gastroenterol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Dysplasia (biliary intraepithelial neoplasia-BilIN) at the cystic duct surgical margin is uncommon. However, no clear guidelines exist regarding optimal management. This study aimed to evaluate management strategies for cystic duct dysplasia (BilIN) detected at the surgical margin based on the available literature.  A literature search was conducted using PubMed and Google Scholar to identify reports of dysplasia or BilIN involving the cystic duct margin in patients undergoing cholecystectomy for benign indications. Eight studies comprising 12 cases were included. High-grade dysplasia was the predominant histopathological finding. Magnetic resonance cholangiopancreatography was performed in 10 cases and revealed findings suspicious for malignancy in two. Nine of 12 patients underwent complementary procedures. Two patients had low-grade dysplasia with negative surgical margins. One patient had a missed cholangiocarcinoma located at the distal cystic duct.  In nine cases, only fibrosis was observed in the cystic duct stump. No malignant transformation was reported during follow-up. Routine complementary surgery for cystic duct margin dysplasia may represent overtreatment in the absence of suspicious radiologic findings. An image-guided, selective reoperation strategy appears appropriate.<\/jats:p>","DOI":"10.1055\/a-2906-2196","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T23:07:08Z","timestamp":1787180828000},"source":"Crossref","is-referenced-by-count":0,"title":["Does Dysplasia at the Cystic Duct Surgical Margin Remain at the Cystic Stump? A Literature Review"],"prefix":"10.1055","author":[{"given":"Nurettin","family":"Kahramansoy","sequence":"additional","affiliation":[{"name":"Ministry of Health Izmir City Hospital, \u0130zmir, T\u00fcrkiye","place":["Izmir"],"department":["Department of General Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zg\u00fcr","family":"\u0130bi\u015f","sequence":"additional","affiliation":[{"name":"Ministry of Health Izmir City Hospital, \u0130zmir, T\u00fcrkiye","place":["Izmir"],"department":["Department of General Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00fcseyin","family":"Esin","sequence":"additional","affiliation":[{"name":"Ministry of Health Izmir City Hospital, \u0130zmir, T\u00fcrkiye","place":["Izmir"],"department":["Department of General Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"ref1","volume-title":"Laparoscopic cholecystectomy","author":"KR Hassler","year":"2023"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.suc.2018.12.004","article-title":"Cholangiocarcinoma","volume":"99","author":"AS Khan","year":"2019","journal-title":"Surg Clin North Am"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"685","DOI":"10.4240\/wjgs.v8.i10.685","article-title":"Incidental non-benign gallbladder histopathology after cholecystectomy in an United Kingdom population: need for routine histological analysis?","volume":"8","author":"K Patel","year":"2016","journal-title":"World J Gastrointest Surg"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"6541","DOI":"10.3748\/wjg.v25.i44.6541","article-title":"Cystic duct cancer: should it be deemed as a type of gallbladder cancer?","volume":"25","author":"T-N Yu","year":"2019","journal-title":"World J Gastroenterol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"696714","DOI":"10.3389\/fonc.2021.696714","article-title":"Cystic Duct Carcinoma: A New Classification System and the Clinicopathological Features of 62 Patients","volume":"11","author":"L Nan","year":"2021","journal-title":"Front Oncol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1038\/modpathol.3800788","article-title":"Biliary intraepithelial neoplasia: an international interobserver agreement study and proposal for diagnostic criteria","volume":"20","author":"Y Zen","year":"2007","journal-title":"Mod pathol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"5358","DOI":"10.3390\/cancers14215358","article-title":"Pathologies of precursor lesions of biliary tract carcinoma","volume":"14","author":"Y Nakanuma","year":"2022","journal-title":"Cancers (Basel)"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.gtc.2023.10.001","article-title":"Dysplasia and early carcinoma of the gallbladder and bile ducts: terminology, classification, and significance","volume":"53","author":"NV Adsay","year":"2024","journal-title":"Gastroenterol Clin North Am"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s00428-014-1689-0","article-title":"Biliary intraepithelial neoplasia (BilIN) is frequently found in surgical margins of biliary tract cancer resection specimens but has no clinical implications","volume":"466","author":"H Matthaei","year":"2015","journal-title":"Virchows Arch"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1111\/his.13975","article-title":"The 2019 WHO classification of tumours of the digestive system","volume":"76","author":"ID Nagtegaal","year":"2020","journal-title":"Histopathology"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"41","DOI":"10.5146\/tjpath.2017.01404","article-title":"A retrospective evaluation of the epithelial changes\/lesions and neoplasms of the gallbladder in Turkey and a review of the existing sampling methods: a multicentre study","volume":"34","author":"G Esenda\u011fli","year":"2018","journal-title":"Turk Patoloji Derg"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.humpath.2018.07.015","article-title":"Distribution of dysplasia and cancer in the gallbladder: an analysis from a high cancer-risk population","volume":"82","author":"J Koshiol","year":"2018","journal-title":"Hum Pathol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1878","DOI":"10.1002\/1097-0142(19930915)72:63.0.co;2-2","article-title":"Metaplasia and precursor lesions of gallbladder carcinoma. 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Yoshida","year":"2019","journal-title":"World J Surg Oncol"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/j.gie.2013.09.017","article-title":"Cholangioscopy with narrow-band imaging in patients with primary sclerosing cholangitis undergoing ERCP","volume":"79","author":"N Azeem","year":"2014","journal-title":"Gastrointest Endosc"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/j.humpath.2007.10.031","article-title":"Biliary neoplasia with extensive intraductal spread associated with liver cirrhosis: a hitherto unreported variant of biliary intraepithelial neoplasia","volume":"39","author":"S Aishima","year":"2008","journal-title":"Hum Pathol"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"G480","DOI":"10.1152\/ajpgi.00011.2022","article-title":"Bile acid detergency: permeability, inflammation, and effects of sulfation","volume":"322","author":"M Camilleri","year":"2022","journal-title":"Am J Physiol 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