{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:26:26Z","timestamp":1787009186753,"version":"build-2736575974"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ultraschall Med"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Although contrast-enhanced ultrasound (CEUS) and dynamic CEUS (DCE-US) are well established in other oncologic entities, their use in neuro-oncology has been limited by the acoustic inaccessibility of the brain through the intact skull. This study investigates the feasibility of the use of DCE-US and ultrasound localization microscopy (ULM) in patients with glioblastoma multiforme (GBM), by utilizing the craniotomy burr hole as an acoustic window.<\/jats:p>\n                  <jats:p>CEUS data from n=8 patients with newly diagnosed or relapsed GBM were retrospectively analyzed. All patients underwent CEUS via the craniotomy burr hole in the bedside setting, and perfusion analysis was conducted on stored cine loops. DCE-US parameters \u2013 time-to-peak (TTP), area under the curve (AUC), wash-in AUC, and washout AUC \u2013 were analyzed in three region-of-interest (ROI) zones: tumor center, margin, and adjacent normal brain. Next, ULM algorithms were applied to multiple frames to reconstruct the GBM tumor microvasculature.<\/jats:p>\n                  <jats:p>Trans-burr hole imaging was feasible in all patients. Differences in TTP, AUC, washout AUC, and signal gradient were observed between the lesion center and both the margin and normal brain tissue, while the margin and the normal brain did not differ. Lesion-center AUC values were significantly higher in confirmed tumor recurrence (n=4) than in reactive gliosis (n=2). Recurrent tumors showed homogeneous, well-defined enhancement, whereas non-tumorous lesions appeared heterogeneous and ill-defined. ULM enabled quantification and visualization of directivity, velocity, and density maps corresponding to tumor anatomy and microbubble dynamics.<\/jats:p>\n                  <jats:p>DCE-US and ULM via the post-surgical burr hole offer a promising, noninvasive tool for perfusion assessment and relapse evaluation in GBM follow-up.<\/jats:p>","DOI":"10.1055\/a-2909-9981","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T22:50:39Z","timestamp":1783464639000},"source":"Crossref","is-referenced-by-count":0,"title":["Bedside trans-burr hole dynamic contrast-enhanced ultrasound (DCE-US) and ultrasound localization microscopy (ULM) in relapsed glioblastoma \u2013 a retrospective comparative case series"],"prefix":"10.1055","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5351-9330","authenticated-orcid":false,"given":"Johannes","family":"Falter","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Regensburg, Germany","place":["Regensburg"],"department":["Department of Neurosurgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernst Michael","family":"Jung","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Regensburg, Germany","place":["Regensburg"],"department":["Department of Radiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henriette","family":"Grieshaber-Bouyer Mandelbaum","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Erlangen, Germany","place":["Erlangen"],"department":["Department of Pediatrics and Adolescent Medicine, Pediatric Experimental and Translational Imaging Laboratory"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Wachter","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Erlangen, Germany","place":["Erlangen"],"department":["Department of Pediatrics and Adolescent Medicine, Pediatric Experimental and Translational Imaging Laboratory"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Gludowatz","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Regensburg, Germany","place":["Regensburg"],"department":["Department of Neurosurgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Anthofer","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Regensburg, Germany","place":["Regensburg"],"department":["Department of Neurosurgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janne","family":"Koskim\u00e4ki","sequence":"additional","affiliation":[{"name":"Oulu University Hospital, Finland","place":["Oulu"],"department":["Department of Neurosurgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinand","family":"Knieling","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Erlangen, Germany","place":["Erlangen"],"department":["Department of Pediatrics and Adolescent Medicine, Pediatric Experimental and Translational Imaging Laboratory"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian Philip","family":"Regensburger","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Erlangen, Germany","place":["Erlangen"],"department":["Department of Pediatrics and Adolescent Medicine, Pediatric Experimental and Translational Imaging Laboratory"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Proescholdt","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Regensburg, Germany","place":["Regensburg"],"department":["Department of Neurosurgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils Ole","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Regensburg, Germany","place":["Regensburg"],"department":["Department of 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