{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T23:28:30Z","timestamp":1786577310896,"version":"build-2736575974"},"reference-count":18,"publisher":"Georg Thieme Verlag KG","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tierarztl Prax Ausg K Kleintiere Heimtiere"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The knowledge regarding Babesia canis infections in puppies is limited to\n                    3 dogs aged 43\u201346 days. A 45-day-old, male intact German Shepherd dog was\n                    presented due to lethargy, inappetence, and gait disorders. An acute Babesia\n                        canis infection was diagnosed by PCR. Marked thrombocytopenia, anemia,\n                    and hyperbilirubinemia were noted. A subcutaneous injection of imidocarb\n                    dipropionate (ID, 2.0\u2009mg\/kg bodyweight) was applied. The puppy\u2019s general\n                    condition significantly improved, but vomitus was noted. A negative PCR and mild\n                    hematological abnormalities were seen 14 days later. A second subcutaneous\n                    injection of ID (4.2\u2009mg\/kg bodyweight) was applied. Babesia canis\n                    infections should be considered in puppies with fever, marked thrombocytopenia,\n                    and marked anemia in the immunological gap. Next to vectorial transmission,\n                    transplacental Babesia canis infections are reported but considered\n                    unlikely in the presented puppy. The puppy responded well to a lower-ranged dose\n                    of ID, but side effects were noted (vomiting). In adult dogs, treatment of acute\n                        Babesia canis infections using ID dosed 6.6\u2009mg\/kg bodyweight is\n                    recommended. No safety regulations are published by the manufacturer regarding\n                    the use of ID in puppies, but vomitus is reported as a potential side effect\n                    after the use in adult dogs. A second ID injection (4.2\u2009mg\/kg bodyweight) was\n                    applied to avoid a potential disease relapse. The case report highlights the\n                    significance of the immunological gap in puppies with Babesia canis\n                    infections and the need for ectoparasite prophylaxis in puppies, if vector\n                    contact is possible.<\/jats:p>","DOI":"10.1055\/a-2910-4836","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T23:10:32Z","timestamp":1786576232000},"source":"Crossref","is-referenced-by-count":0,"title":["Clinicopathological abnormalities, treatment, and outcome in in a\n                    45-day-old puppy with acute Babesia canis infection"],"prefix":"10.1055","author":[{"given":"Ingo","family":"Sch\u00e4fer","sequence":"additional","affiliation":[{"name":"Laboklin GmbH and Co. KG, Bad Kissingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"St\u00fcwe","sequence":"additional","affiliation":[{"name":"Tierarztpraxis F\u00fcrst, Angern, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"F\u00fcrst","sequence":"additional","affiliation":[{"name":"Tierarztpraxis F\u00fcrst, Angern, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Strube","sequence":"additional","affiliation":[{"name":"Institute for Parasitology, Centre for Infection Medicine, University\n                    of Veterinary Medicine Hannover, Hanover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Laboklin GmbH and Co. KG, Bad Kissingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten J.","family":"Naucke","sequence":"additional","affiliation":[{"name":"Laboklin GmbH and Co. KG, Bad Kissingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Moritz","sequence":"additional","affiliation":[{"name":"Small animal clinic \u2013 Internal Medicine, Department of Veterinary\n                    Medicine, Justus-Liebig-University Giessen, Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"102225","DOI":"10.1016\/j.ttbdis.2023.102225","article-title":"Winter activity of questing ticks (Ixodes ricinus and Dermacentor reticulatus)\n                    in Germany \u2013 Evidence from quasi-natural tick plots, field studies and a tick\n                    submission study","volume":"14","author":"J Probst","year":"2023","journal-title":"Ticks Tick Borne Dis"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/s13071-023-05693-5","article-title":"Year-round tick exposure of dogs and cats in Germany and Austria: results from a\n                    tick collection study","volume":"16","author":"J Probst","year":"2023","journal-title":"Parasit Vectors"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1186\/s13071-023-06005-7","article-title":"Molecular detection of Babesia spp. in dogs in Germany (2007\u20132020) and\n                    identification of potential risk factors for infection","volume":"16","author":"I Sch\u00e4fer","year":"2023","journal-title":"Parasit Vectors"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"578220","DOI":"10.3389\/fvets.2020.578220","article-title":"The spatial distribution of Dermacentor ticks (Ixodidae) in Germany-Evidence of\n                    a continuing spread of Dermacentor reticulatus","volume":"7","author":"M 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Germany","volume":"18","author":"I M Von Hohnhorst","year":"2025","journal-title":"Parasit Vectors"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1055\/a-1704-6604","volume-title":"Occurrence of canine babesiosis in dogs in the Rhine-Main area of Hesse, Germany\n                    \u2013 a case study of 81 dogs","author":"S Seibert","year":"2022"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"500","DOI":"10.5604\/12321966.1120590","article-title":"The first evidence for vertical transmission of Babesia canis in a litter of\n                    Central Asian Shepherd dogs","volume":"21","author":"E J Mierzejewska","year":"2014","journal-title":"Ann Agric Environ Med"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-016-1596-0","article-title":"A review of canine babesiosis: the European perspective","volume":"9","author":"L Solano-Gallego","year":"2016","journal-title":"Parasites & Vectors"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.vetpar.2006.05.002","article-title":"Capillary and venous Babesia canis rossi parasitaemias and their association\n                    with outcome of infection and circulatory compromise","volume":"141","author":"M B\u00f6hm","year":"2006","journal-title":"Veterinary Parasitology"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens8030094","article-title":"Mechanisms involved in the persistence of Babesia canis infection in dogs","volume":"8","author":"T Schetters","year":"2019","journal-title":"Pathogens"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1024\/0036-7281.148.12.633","article-title":"Bedeutung der PCR in der Diagnostik der caninen Babesiose","volume":"148","author":"D Schaarschmidt","year":"2006","journal-title":"Schweizer Archiv fuer 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Greene\u2019s Infectious DIseases of the Dog and\n                    the Cat. 5th ed","author":"A J Birkenheuer","year":"2023"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"S10","DOI":"10.1016\/j.jcpa.2007.04.005","article-title":"Immune system development in the dog and cat","volume":"137","author":"M J Day","year":"2007","journal-title":"J Comp Pathol"}],"container-title":["Tier\u00e4rztliche Praxis Ausgabe K: Kleintiere \/ Heimtiere"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2910-4836.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T23:10:33Z","timestamp":1786576233000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2910-4836"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,12]]},"references-count":18,"URL":"https:\/\/doi.org\/10.1055\/a-2910-4836","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["1434-1239","2567-5842"],"issn-type":[{"value":"1434-1239","type":"print"},{"value":"2567-5842","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,12]]}}}