{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:53:31Z","timestamp":1791500011219,"version":"4.3.4"},"reference-count":40,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nuklearmedizin"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>[18F]FDG positron-emission-tomography\/computed tomography (PET\/CT) is a crucial tool in paediatric oncology for staging, treatment response assessment, and follow-up imaging. Long axial field of view (LAFOV) PET\/CT is more sensitive for the detection of annihilation events than short axial field of view (SAFOV) instrumentation, thus enabling lower radiation dose and\/or briefer acquisition time. In consideration of the radiation sensitivity of children, we compared the performance of LAFOV and SAFOV PET\/CT in paediatric oncology.<\/jats:p>\n                  <jats:p>Twenty-six paediatric oncology patients (mean age 13.7 \u00b1 4.8 y), of whom half had diagnosis of lymphoma,  underwent 37 [18F]FDG PET\/CT scans (12 SAFOV, 25 LAFOV). The LAFOV acquisitions (1\u20133 MBq\/kg) were numerically rescaled to simulate 0.5\u20133 MBq\/kg, yielding 75 LAFOV studies. Four blinded readers rated image quality on a 5-point Likert scale, and recorded various imaging metrics, statistical comparison, and power calculations.<\/jats:p>\n                  <jats:p>LAFOV at 2 and 3 MBq\/kg achieved significantly higher Likert ratings than SAFOV. LAFOV at 1 MBq\/kg yielded comparable ratings to SAFOV (p=0.13), while 0.5 MBq\/kg was inferior to SAFOV (p=0.012). Hepatic background SD decreased and SNR increased dose-dependently with LAFOV (p&lt;0.001), whereas lesion SUVmax and SUVmean remained stable across scanners. TBR was lower for LAFOV at higher doses, despite unchanged image quality. Inter-rater agreement was fair to moderate.<\/jats:p>\n                  <jats:p>LAFOV PET\/CT supports [18F]FDG dose reduction without impairing image quality for lesion detection. 1 MBq\/kg yielded diagnostic quality comparable to SAFOV, while 2\u20133 MBq\/kg provided superior performance. These results support LAFOV PET\/CT as a strategy to minimize radiation exposure in children.<\/jats:p>","DOI":"10.1055\/a-2912-4818","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T22:44:42Z","timestamp":1784846682000},"page":"312-320","source":"Crossref","is-referenced-by-count":0,"title":["FDG-PET\/CT in children with malignant diseases \u2013 comparison of a long axial field of view scanner with a standard scanner"],"prefix":"10.1055","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4182-3516","authenticated-orcid":false,"given":"Wolfram A","family":"Bosbach","sequence":"additional","affiliation":[{"name":"University of Bern, Switzerland","place":["Bern"],"department":["Inselspital, Bern University Hospital, Department of Nuclear Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentin","family":"Manser","sequence":"additional","affiliation":[{"name":"University of Bern, Switzerland","place":["Bern"],"department":["Inselspital, Bern University Hospital, Department of Nuclear Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carola M","family":"Bregenzer","sequence":"additional","affiliation":[{"name":"University of Bern, Switzerland","place":["Bern"],"department":["Inselspital, Bern University Hospital, Department of Nuclear Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasir","family":"G\u00f6zl\u00fcg\u00f6l","sequence":"additional","affiliation":[{"name":"University of Bern, Switzerland","place":["Bern"],"department":["Inselspital, Bern University Hospital, Department of Nuclear Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Korbinian","family":"Krieger","sequence":"additional","affiliation":[{"name":"University of Bern, Switzerland","place":["Bern"],"department":["Inselspital, Bern University Hospital, Department of Nuclear Medicine"]},{"name":"Cantonal Hospital Winterthur, Switzerland","place":["Winterthur"],"department":["Clinic for Radiology and Nuclear Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Zeimpekis","sequence":"additional","affiliation":[{"name":"University of Bern, Switzerland","place":["Bern"],"department":["Inselspital, Bern University Hospital, Department of Nuclear Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela Filipa Silva","family":"Mendes","sequence":"additional","affiliation":[{"name":"University of Bern, Switzerland","place":["Bern"],"department":["Inselspital, Bern University Hospital, Department of Nuclear Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swantje","family":"Engelbrecht","sequence":"additional","affiliation":[{"name":"University of Bern, Switzerland","place":["Bern"],"department":["Inselspital, Bern University Hospital, Department of Nuclear 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Switzerland","place":["Bern"],"department":["Inselspital, Bern University Hospital, Department of Nuclear Medicine"]},{"name":"Siemens Healthcare AG, Switzerland","place":["Lausanne"],"department":["Advanced Clinical Imaging Technology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Cumming","sequence":"additional","affiliation":[{"name":"University of Bern, Switzerland","place":["Bern"],"department":["Inselspital, Bern University Hospital, Department of Nuclear Medicine"]},{"name":"Queensland University of Technology, Australia","place":["Brisbane"],"department":["School of Psychology and Counselling"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens","family":"Mingels","sequence":"additional","affiliation":[{"name":"University of Bern, Switzerland","place":["Bern"],"department":["Inselspital, Bern University Hospital, Department of Nuclear 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