{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:01:23Z","timestamp":1785369683961,"version":"3.55.0"},"reference-count":40,"publisher":"Georg Thieme Verlag KG","funder":[{"name":"Fundamental Research Funds for the China Institute of Sport Science","award":["13-13, 14-08"],"award-info":[{"award-number":["13-13, 14-08"]}]},{"name":"National Science & Technology Pillar Program during the Twelfth Five-Year Plan Period","award":["2012BAK23B01"],"award-info":[{"award-number":["2012BAK23B01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Sports Med"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study compared serum irisin concentration changes following 16 weeks of different exercise protocols (hill, running, cycling, and combined) versus control in 289 previously sedentary adults. We identified phenotypic and genetic predictors to establish an irisin response prediction model for precise exercise prescription. Phenotypic measures (serum irisin, maximal oxygen consumption, and lipids) and fibronectin type-III domain containing protein-5 genen single nucleotide polymorphism (rs16835198) genotyping were performed pre\/post-intervention. Serum irisin significantly increased post-exercise overall (p&lt;0.05), but with substantial interindividual variability (\u0394 range:\u22124.98 to 20.77 ng\/mL; 28.03% responders, Cohen\u2019s d\u22650.2). Under the specific (and unstandardized) exercise volumes utilized in this study, hill and combined training elicited the most significant increases (p&lt;0.01). Cohen\u2019s d-based irisin change effect size significantly correlated with baseline maximal oxygen consumption (r=0.164 and p&lt;0.01) and irisin levels (r=0.481 and p&lt;0.05). It was also linked to FNDC5 rs16835198 (p=0.041), with the TT genotype exhibiting greater responses than GT\/GG genotypes. A model incorporating baseline serum irisin concentrations (\u03b2=0.522), maximal oxygen consumption (\u03b2=0.107), exercise protocols (\u03b2=0.207), and rs16835198 genotype (\u03b2=0.116) explained 27.1% of the variance in the effect size of \u0394irisin. In short, exercise-induced irisin elevation exhibited marked individual variability. Baseline irisin, maximal oxygen consumption, FNDC5 rs16835198 genotype, and exercise protocol are significant predictors, accounting for 27.1% of the individual differences in training response, informing precision exercise prescription. Keywords: Irisin; Individual differences; Effect of exercise intervention; prediction model.<\/jats:p>","DOI":"10.1055\/a-2912-9831","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T22:54:22Z","timestamp":1783724062000},"source":"Crossref","is-referenced-by-count":0,"title":["Predictive Factors for Changes in Serum Irisin Concentrations after Different Exercise Interventions"],"prefix":"10.1055","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1225-8936","authenticated-orcid":false,"given":"Tong","family":"Chen","sequence":"additional","affiliation":[{"name":"China Institute of Sport Science, China","place":["Beijing"],"department":["Comprehensive Experimental Center"]},{"name":"Zhengzhou Physical Education vocational College, China","place":["Zhengzhou"],"department":["College of Physical Education"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuangzhuang","family":"Gu","sequence":"additional","affiliation":[{"name":"Henan Normal University, China","place":["Xinxiang"],"department":["Institute of Physical Education"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihong","family":"He","sequence":"additional","affiliation":[{"name":"China Institute of Sport Science, China","place":["Beijing"],"department":["Comprehensive Experimental Center"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/nature10777","article-title":"A PGC1-\u03b1-dependent myokine that drives brown-fat-like development of white fat and thermogenesis","volume":"481","author":"P Bostr\u00f6m","year":"2012","journal-title":"Nature"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"101680","DOI":"10.1016\/j.arr.2022.101680","article-title":"Irisin, an exercise-induced bioactive peptide beneficial for health promotion during aging process","volume":"80","author":"H Zhang","year":"2022","journal-title":"Ageing Res Rev"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-025-04083-1","article-title":"The role of irisin in exercise-induced muscle and metabolic health: A narrative review","author":"S N Mohammed","year":"2025","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"8235809","DOI":"10.1155\/2022\/8235809","article-title":"Comparative impact of various exercises on circulating irisin in healthy subjects: A systematic review and network meta-analysis","volume":"2022","author":"F Kazeminasab","year":"2022","journal-title":"Oxid Med Cell Longevity"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.metabol.2015.12.006","article-title":"Effect of sprint training on resting serum irisin concentration\u2014Sprint training once daily vs. twice every other day","volume":"65","author":"Y Tsuchiya","year":"2016","journal-title":"Metabolism"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1186\/1741-7015-11-235","article-title":"Irisin and exercise training in humans\u2014results from a randomized controlled training trial","volume":"11","author":"A Hecksteden","year":"2013","journal-title":"BMC Med"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"457","DOI":"10.33549\/physiolres.934896","article-title":"The effects of different types of exercise on circulating irisin levels in healthy individuals and in people with overweight, metabolic syndrome and type 2 diabetes","volume":"71","author":"S G Parada-S\u00e1nchez","year":"2022","journal-title":"Physiol Res"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.3389\/fphys.2018.01735","article-title":"Myokine response to high-intensity interval vs. resistance exercise: An individual approach","volume":"9","author":"Z He","year":"2018","journal-title":"Front Physiol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1515\/cclm-2017-0674","article-title":"Is irisin the new player in exercise-induced adaptations or not? 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