{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T23:46:42Z","timestamp":1785887202513,"version":"3.56.0"},"reference-count":27,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rofo"],"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Die \u00b9\u2078F-FDG-PET\/CT hat sich als sensitive Ganzk\u00f6rperbildgebung in der Infektions- und Entz\u00fcndungsdiagnostik etabliert und liefert bei komplexen oder atypischen Pr\u00e4sentationen entscheidende diagnostische Informationen. Bei Fieber unklarer Genese und systemischen Infektionen kann die \u00b9\u2078F-FDG-PET\/CT auch nach vorheriger konventioneller Diagnostik in etwa 50\u201379% der F\u00e4lle noch klinisch relevante Informationen liefern und gezielte Therapieentscheidungen erm\u00f6glichen. In der Diagnostik von Prothesen- und Implantatinfektionen, einschlie\u00dflich Herzschrittmacher-, LVAD- oder Gef\u00e4\u00dfprotheseninfektionen, stellt die \u00b9\u2078F-FDG-PET\/CT eine wertvolle Erg\u00e4nzung zur CT und MRT dar; Meta-Analysen berichten bei periprothetischen Infektionen Sensitivit\u00e4t und Spezifit\u00e4t von etwa 86%. Bei Klappenprothesen-Endokarditis erh\u00f6ht sie die Diagnosesicherheit deutlich gegen\u00fcber der Sonografie, ist in der ESC-Endokarditis-Leitlinie (2023) als empfohlene Zusatzmodalit\u00e4t gef\u00fchrt und erreicht Sensitivit\u00e4t und Spezifit\u00e4t von 80\u201387%. Bei nativer Endokarditis weist die \u00b9\u2078F-FDG-PET\/CT eine geringere Sensitivit\u00e4t auf. Bei Spondylodiszitis und Osteomyelitis zeigen meta-analytische Daten Sensitivit\u00e4ten und Spezifit\u00e4ten von etwa 95% bzw. 88\u201391%; Beobachtungsdaten weisen auf eine Assoziation mit niedrigeren station\u00e4ren Sterblichkeitsraten hin, ohne einen kausalen Zusammenhang zu belegen.Diese Ergebnisse haben wesentlich zur Aktualisierung internationaler Leitlinien und Prozedurstandards beigetragen. Die gemeinsamen Leitlinien der EANM und SNMMI (2024\/2025) best\u00e4tigen die Evidenz und geben praxisorientierte Empfehlungen f\u00fcr Indikationen, Protokolle und die Interpretation der \u00b9\u2078F-FDG-PET\/CT in der Infektions- und Entz\u00fcndungsdiagnostik.<\/jats:p>","DOI":"10.1055\/a-2913-6380","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T22:57:27Z","timestamp":1785884247000},"source":"Crossref","is-referenced-by-count":0,"title":["PET\/CT in der Diagnostik infekti\u00f6ser und entz\u00fcndlicher Erkrankungen"],"prefix":"10.1055","author":[{"given":"Emil","family":"Wachenfeld","sequence":"additional","affiliation":[{"name":"Medical Center \u2013 University of Freiburg, Germany","place":["Freiburg"],"department":["Department of Diagnostic and Interventional Radiology"]},{"name":"Institute and Policlinic of Radiology, Pediatric Radiology and Neuroradiology, Germany","place":["Rostock"],"department":["University Medical Center Rostock"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Wei\u00df","sequence":"additional","affiliation":[{"name":"Medical Center \u2013 University of Freiburg, Germany","place":["Freiburg"],"department":["Department of Diagnostic and Interventional Radiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Schwarzenb\u00f6ck","sequence":"additional","affiliation":[{"name":"University Medical Centre of Rostock, Germany","place":["Rostock"],"department":["Deparment of Nuclear Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3918-8066","authenticated-orcid":false,"given":"Marc-Andr\u00e9","family":"Weber","sequence":"additional","affiliation":[{"name":"Institute and Policlinic of Radiology, Pediatric Radiology and Neuroradiology, Germany","place":["Rostock"],"department":["University Medical Center 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