{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T22:53:29Z","timestamp":1791500009085,"version":"4.3.4"},"reference-count":15,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nuklearmedizin"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>99m Tc-sestamibi single-photon emission computed tomography\/computed tomography (SPECT\/CT) is a cost-effective and accurate means of characterizing indeterminate renal masses. This is scant literature on 99m Tc-sestamibi protocol optimization.<\/jats:p>\n                  <jats:p>We investigated the difference between modeled, quantitative 180-degree and 360-degree acquisitions for 99mTc-sestamibi SPECT\/CT in a cohort of 50 patients who were prospectively enrolled on a scan-and-resect protocol. Two experienced, dual-boarded observers rated each renal mass for image quality (1\u20135 scale) and diagnosis (benign to malignant, 1\u20135 scale) in a blinded, randomized order. Ordinal logistic regression was used, incorporating random intercepts for patient and reader; inter-observer variability was assessed.<\/jats:p>\n                  <jats:p>Image quality ratings were significantly higher for 360-degree acquisitions versus 180-degree (P&lt;0.0001; odds ratio 0.22, 95% CI 0.12\u20130.39). The odds ratio was 0.22 (95% CI: 0.12, 0.39). There was insufficient evidence that the modeled angle of acquisition was associated with scan positivity (P=0.17). The odds ratio was 0.67 (95% CI: 0.37, 1.19). Diagnostic positivity ratings did not differ between reconstruction angles (P=0.17; odds ratio 0.67, 95% CI 0.37\u20131.19).<\/jats:p>\n                  <jats:p>Modeled 180-degree reconstructions of quantitative SPECT\/CT are qualitatively inferior to quantitative reconstructions of 360-degree acquisitions, although there was no difference in the diagnostic accuracy between the reconstruction methods. These results suggest that 180-degree acquisitions are adequate for diagnosis.<\/jats:p>","DOI":"10.1055\/a-2914-2268","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:40:56Z","timestamp":1786495256000},"page":"323-327","source":"Crossref","is-referenced-by-count":0,"title":["Quantitative Reconstructions for Renal Sestamibi SPECT\/CT: A Modeled Comparison of 360-Degree Versus 180-Degree Acquisitions"],"prefix":"10.1055","volume":"65","author":[{"given":"Yong","family":"Du","sequence":"first","affiliation":[{"name":"Johns Hopkins University School of Medicine, MD, USA","place":["Baltimore"],"department":["The Russell H. Morgan Department of Radiology and Radiological Science"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven P.","family":"Rowe","sequence":"first","affiliation":[{"name":"University of Texas Southwestern Medical Center, TX, USA","place":["Dallas"],"department":["Department of Radiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge D.","family":"Oldan","sequence":"additional","affiliation":[{"name":"University of North Carolina, NC, USA","place":["Chapel Hill"],"department":["Division of Molecular Imaging and Therapeutics, Department of Radiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A.","family":"Schroeder","sequence":"additional","affiliation":[{"name":"University of North Carolina, NC, USA","place":["Chapel Hill"],"department":["Division of Molecular Imaging and Therapeutics, Department of Radiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathurika","family":"Jeyasingam","sequence":"additional","affiliation":[{"name":"SUNY Upstate University Hospital, NY, USA","place":["Syracuse"],"department":["Department of Interventional Radiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilja B.","family":"Solnes","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine, MD, USA","place":["Baltimore"],"department":["The Russell H. Morgan Department of Radiology and Radiological Science"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emi Lou","family":"Mondragon","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine, MD, USA","place":["Baltimore"],"department":["The Russell H. Morgan Department of Radiology and Radiological Science"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thad","family":"Benefield","sequence":"additional","affiliation":[{"name":"University of North Carolina, NC, USA","place":["Chapel Hill"],"department":["Biostatistics, Department of Radiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad E.","family":"Allaf","sequence":"additional","affiliation":[{"name":"Johns Hopkins University School of Medicine, MD, USA","place":["Baltimore"],"department":["The James Buchanan Brady Urological Institute and Department of Urology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Tulchinsky","sequence":"additional","affiliation":[{"name":"Pennsylvania State University College of Medicine, PA, USA","place":["Hershey"],"department":["Department of Radiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Gorin","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, NY, USA","place":["New York"],"department":["The Milton and Carroll Petrie Department of Urology, Icahn School of Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.1007\/s12350-018-1283-y","article-title":"Single Photon Emission Computed Tomography (SPECT) Myocardial Perfusion Imaging Guidelines: Instrumentation, Acquisition, Processing, and Interpretation","volume":"25","author":"S Dorbala","year":"2018","journal-title":"J Nucl Cardiol"},{"issue":"04","key":"ref2","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1053\/j.semnuclmed.2023.02.004","article-title":"Parathyroid Imaging","volume":"53","author":"MN Lalonde","year":"2023","journal-title":"Semin Nucl 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