{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:58Z","timestamp":1785369658416,"version":"3.55.0"},"reference-count":31,"publisher":"Georg Thieme Verlag KG","issue":"CP","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Purpose Percutaneous drainage is the standard nonsurgical treatment for liver abscess. Recent retrospective studies suggest that endoscopic ultrasound (EUS)-guided drainage may be an effective and safe alternative. We conducted a systematic review and meta-analysis to evaluate the efficacy and safety of EUS-guided drainage as a stand-alone approach and in comparison, with percutaneous drainage.<\/jats:p>\n                  <jats:p>Methods PubMed, EMBASE, and Cochrane databases were searched from inception through November 2025. The primary outcome was clinical success; secondary outcomes included technical success, total adverse events, and abscess relapse. Sensitivity analyses using a treatment-arm continuity correction were performed to address zero-event cells.<\/jats:p>\n                  <jats:p>Results Eleven studies were included (EUS, n = 186; percutaneous drainage, n = 325). In single-arm studies, pooled technical and clinical success rates with EUS were both 1.00 (95% CI, 0.95\u20131.00 and 0.99\u20131.00, respectively). Pooled total adverse event and relapse rates were 0.02 (95% CI, 0.00\u20130.12) and 0.00 (95% CI, 0.00\u20130.01), respectively. Comparative studies showed no significant differences between EUS and percutaneous drainage in technical success (RR 1.00, 95% CI, 0.83\u20131.19) or clinical success (RR 1.02, 95% CI, 0.86\u20131.22). EUS was associated with a significantly lower risk of total adverse events (RR 0.34, 95% CI, 0.15\u20130.76), while relapse rates were similar (RR 0.83, 95% CI, 0.30\u20132.33). Sensitivity analyses yielded consistent findings across all outcomes.<\/jats:p>\n                  <jats:p>Conclusion EUS-guided drainage is an effective and safe treatment for liver abscesses primarily involving the left hepatic and caudate lobes. Although EUS was associated with a lower risk for adverse events, larger comparative studies are needed to define its role in right lobe abscesses.<\/jats:p>","DOI":"10.1055\/a-2919-1534","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T23:45:20Z","timestamp":1785368720000},"source":"Crossref","is-referenced-by-count":0,"special_numbering":"S","title":["Efficacy and Safety of Endoscopic Ultrasound-Guided Drainage in Liver Abscess Management: A Systematic Review and Meta-Analysis"],"prefix":"10.1055","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2661-978X","authenticated-orcid":false,"given":"Spyridon","family":"Peppas","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine, Texas, United States","place":["Houston"],"department":["Section of Gastroenterology, Hepatology & 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States","place":["Houston"],"department":["Section of Gastroenterology, Hepatology & Nutrition"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salmaan","family":"Jawaid","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine, Texas, United States","place":["Houston"],"department":["Section of Gastroenterology, Hepatology & Nutrition"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wasif","family":"Abidi","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine, Texas, United States","place":["Houston"],"department":["Section of Gastroenterology, Hepatology & Nutrition"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalpesh","family":"Patel","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine, Texas, United States","place":["Houston"],"department":["Section of Gastroenterology, Hepatology & 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