{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T23:15:27Z","timestamp":1788218127537,"version":"build-2803163510"},"reference-count":7,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aktuelle Urol"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title>\n                  <jats:p>Hochintensiver fokussierter Ultraschall (HIFU) ist eine minimalinvasive Therapieoption bei selektierten Patienten mit lokalisiertem Prostatakarzinom. Der Beitrag stellt keinen Ergebnisbericht einer Originalstudie dar, sondern einen praxisorientierten Erfahrungsbericht und ein Expertenreview zur Durchf\u00fchrung der fokalen beziehungsweise hemiablativen HIFU.<\/jats:p>\n                  <jats:p>Beschrieben werden Patientenselektion, pr\u00e4operative Diagnostik, Mapping Biopsie, intraoperative Planung, Sicherheitsabst\u00e4nde, Ablationsdurchf\u00fchrung mittels EDAP\/Focal One(R), Double Tap Strategie sowie Nachsorge. Institutionelle Vorgehensweisen werden als solche gekennzeichnet und von literaturgest\u00fctzten Grundprinzipien abgegrenzt.<\/jats:p>\n                  <jats:p>Zentral f\u00fcr reproduzierbare Ergebnisse sind die Kongruenz von Bildgebung und Histologie, ein ausreichender Sicherheitssaum um die Indexl\u00e4sion, eine nachvollziehbare intraoperative Dokumentation und eine strukturierte Nachsorge mit PSA Verlauf, mpMRT und Kontrollbiopsie. Die Double Tap Strategie wird als institutionell etablierte technische Modifikation dargestellt; die hierzu vorliegenden eigenen Daten werden kurz eingeordnet.<\/jats:p>\n                  <jats:p>HIFU kann bei standardisierter Durchf\u00fchrung sicher durchgef\u00fchrt werden. Die Qualit\u00e4t h\u00e4ngt wesentlich von Selektion, Planung, technischer Durchf\u00fchrung und posttherapeutischer Kontrolle ab.<\/jats:p>","DOI":"10.1055\/a-2919-7470","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T22:33:56Z","timestamp":1788215636000},"page":"465-470","source":"Crossref","is-referenced-by-count":0,"title":["HIFU \u2013 wie am besten durchgef\u00fchrt"],"prefix":"10.1055","volume":"57","author":[{"given":"Georg","family":"Salomon","sequence":"additional","affiliation":[{"name":"Martini-Klinik am UKE GmbH, Germany","place":["Hamburg"],"department":["Martini-Klinik"]},{"name":"Arbeitskreis Fokale Therapie und Mikrotherapie der Akademie (AKFM), Germany","place":["D\u00fcsseldorf"],"department":["Deutsche Gesellschaft f\u00fcr Urologie (DGU) e.V."]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neele","family":"Heckmann","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Schleswig-Holstein, Germany","place":["Kiel"],"department":["Klinik f\u00fcr Urologie"]},{"name":"Martini-Klinik am UKE GmbH, Germany","place":["Hamburg"],"department":["Martini-Klinik"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Lukas","family":"Hohenhorst","sequence":"additional","affiliation":[{"name":"Martini-Klinik am UKE GmbH, Germany","place":["Hamburg"],"department":["Martini-Klinik"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Ekrutt","sequence":"additional","affiliation":[{"name":"Martini-Klinik am UKE GmbH, Germany","place":["Hamburg"],"department":["Martini-Klinik"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Palec","sequence":"additional","affiliation":[{"name":"Martini-Klinik am UKE GmbH, Germany","place":["Hamburg"],"department":["Martini-Klinik"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2108-010X","authenticated-orcid":false,"given":"Yamini","family":"Nagaraj","sequence":"additional","affiliation":[{"name":"Martini-Klinik am UKE GmbH, Germany","place":["Hamburg"],"department":["Martini-Klinik"]},{"name":"Arbeitskreis Fokale Therapie und Mikrotherapie der Akademie (AKFM), Germany","place":["D\u00fcsseldorf"],"department":["Deutsche Gesellschaft f\u00fcr Urologie (DGU) e.V."]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1097\/MOU.0000000000000053","article-title":"High-intensity focused ultrasound as focal therapy of prostate cancer","volume":"24","author":"S Crouzet","year":"2014","journal-title":"Curr Opin Urol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.clinimag.2019.03.004","article-title":"Characterization and PI-RADS version 2 assessment of prostate cancers missed by prebiopsy 3-T multiparametric MRI: correlation with whole-mount thin-section histopathology","volume":"55","author":"KJ Park","year":"2019","journal-title":"Clin Imaging"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.juro.2015.02.080","article-title":"Image guided focal therapy for magnetic resonance imaging visible prostate cancer: defining a 3-dimensional treatment margin based on magnetic resonance imaging histology co-registration analysis","volume":"194","author":"J Le Nobin","year":"2015","journal-title":"J Urol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1038\/s41391-024-00921-0","article-title":"Focal therapy using high-intensity focused ultrasound with intraoperative prostate compression for patients with localized prostate cancer: a multi-center prospective study with 7 year experience","volume":"28","author":"S Shoji","year":"2025","journal-title":"Prostate Cancer Prostatic Dis"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"e816","DOI":"10.1097\/01.JU.0001008924.16121.42.08","article-title":"PD39\u201308 Double tap focal therapy with high intensity focused ultrasound reduces infield recurrence","volume":"211","author":"Y Nagaraj","year":"2024","journal-title":"J Urol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1148\/rycan.240269","article-title":"Multiparametric MRI before and after focal therapy for prostate cancer: pearls and pitfalls for the reporting radiologist","volume":"7","author":"AL Lai","year":"2025","journal-title":"Radiol Imaging Cancer"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1038\/s41391-024-00905-0","article-title":"Surveillance after focal therapy - 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