{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:44:40Z","timestamp":1785800680812,"version":"3.56.0"},"reference-count":11,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":23,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg Rep"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background Hemangioblastomas are benign, highly vascular World Health Organization (WHO) grade 1 tumors that most commonly arise in the cerebellum. Brainstem involvement is uncommon, and lesions originating from the cervicomedullary junction with extensive caudal cystic extension into the cervical spinal cord are exceptionally rare, posing significant diagnostic and microsurgical challenges.<\/jats:p>\n                  <jats:p>Case Description A 39-year-old man presented with a 2-year history of progressive paresthesia involving both upper limbs, right-sided weakness, gait imbalance, and cerebellar symptoms. Magnetic resonance imaging demonstrated a vividly enhancing mural nodule arising from the dorsal cervicomedullary junction associated with an elongated intramedullary cystic cavity extending caudally to the C3 vertebral level, accompanied by cord edema and syringomyelia. Evaluation for von Hippel\u2013Lindau disease was negative. The patient underwent gross total microsurgical excision through a midline suboccipital craniectomy with C1 laminectomy. Histopathological examination confirmed hemangioblastoma (WHO grade 1). The postoperative course was uneventful, with significant neurological improvement during follow-up.<\/jats:p>\n                  <jats:p>Conclusion Primary cervicomedullary hemangioblastoma with extensive cervical cystic extension is an exceptionally rare lesion. Careful preoperative imaging evaluation, meticulous microsurgical technique, and complete tumor excision can achieve favorable neurological outcomes. Comparison with previously reported cases highlights the rarity of this presentation and supports gross total resection as the treatment of choice whenever safely feasible.<\/jats:p>","DOI":"10.1055\/a-2920-0717","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:44:48Z","timestamp":1784940288000},"page":"e136-e140","source":"Crossref","is-referenced-by-count":0,"title":["Primary Cervicomedullary Hemangioblastoma with Extensive Caudal Cystic Extension into the Cervical Cord: A Case Report and Literature Review"],"prefix":"10.1055","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0464-4367","authenticated-orcid":false,"given":"Shubham","family":"Singh","sequence":"additional","affiliation":[{"name":"Institute of Medical Sciences, Banaras Hindu University, Uttar Pradesh, India","place":["Varanasi"],"department":["Department of Neurosurgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi Shankar","family":"Prasad","sequence":"additional","affiliation":[{"name":"Institute of Medical Sciences, Banaras Hindu University, Uttar Pradesh, India","place":["Varanasi"],"department":["Department of Neurosurgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"issue":"04","key":"ref1","first-page":"632","article-title":"Sporadic hemangioblastomas of the central nervous system: clinical characteristics and outcomes","volume":"117","author":"S A Mills","year":"2012","journal-title":"J Neurosurg"},{"issue":"07","key":"ref2","first-page":"670","article-title":"Brainstem hemangioblastoma: surgical considerations and outcomes","volume":"14","author":"D K Lee","year":"2007","journal-title":"J Clin Neurosci"},{"issue":"05","key":"ref3","first-page":"E11","article-title":"Brainstem hemangioblastomas: review of surgical management","volume":"15","author":"C Roonprapunt","year":"2003","journal-title":"Neurosurg Focus"},{"issue":"05","key":"ref4","first-page":"880","article-title":"Intramedullary ependymoma and hemangioblastoma of the spinal cord: management and outcome","volume":"26","author":"P C McCormick","year":"1990","journal-title":"Neurosurgery"},{"issue":"21","key":"ref5","first-page":"E640","article-title":"Hemangioblastoma of the cervicomedullary junction: a case report and review of the literature","volume":"30","author":"K L Chuah","year":"2005","journal-title":"Spine"},{"issue":"9374","key":"ref6","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1016\/S0140-6736(03)13643-4","article-title":"von Hippel-Lindau disease","volume":"361","author":"R R Lonser","year":"2003","journal-title":"Lancet"},{"issue":"01","key":"ref7","first-page":"55","article-title":"Hemangioblastomas of the central nervous system in von Hippel-Lindau syndrome and sporadic disease","volume":"48","author":"J E Conway","year":"2001","journal-title":"Neurosurgery"},{"issue":"8749","key":"ref8","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/0140-6736(91)91705-Y","article-title":"Clustering of features of von Hippel-Lindau syndrome: evidence for a complex genetic locus","volume":"337","author":"H P Neumann","year":"1991","journal-title":"Lancet"},{"issue":"06","key":"ref9","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s00401-016-1545-1","article-title":"The 2016 World Health Organization classification of tumors of the central nervous system: a summary","volume":"131","author":"D N Louis","year":"2016","journal-title":"Acta Neuropathol"},{"issue":"06","key":"ref10","first-page":"e825","article-title":"Surgical strategies for brainstem hemangioblastomas","volume":"82","author":"T Fukushima","year":"2014","journal-title":"World Neurosurg"},{"key":"ref11","doi-asserted-by":"crossref","DOI":"10.55418\/9781933477015","volume-title":"Tumors of the Central Nervous System","author":"P C Burger","year":"2007"}],"container-title":["Journal of Neurological Surgery Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2920-0717.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T22:53:46Z","timestamp":1785797626000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2920-0717"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":11,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2026,7,17]]},"published-print":{"date-parts":[[2026,7]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2920-0717","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2193-6358","2193-6366"],"issn-type":[{"value":"2193-6358","type":"print"},{"value":"2193-6366","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,7,24]]},"published":{"date-parts":[[2026,7]]}}}