{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T23:05:21Z","timestamp":1789427121213,"version":"build-2803163510"},"reference-count":63,"publisher":"Georg Thieme Verlag KG","issue":"09","funder":[{"name":"The Fund of The First Hospital of Lanzhou\n                        University","award":["ZX-62000002-2023-242"],"award-info":[{"award-number":["ZX-62000002-2023-242"]}]},{"name":"The Major Scientific Research Project on Health and Wellness\n                        Industry Technology Innovation in Gansu Province","award":["GSWSZD2024-12"],"award-info":[{"award-number":["GSWSZD2024-12"]}]},{"name":"Science and Technology Program Funding of Gansu\n                        Province","award":["24JRRA1087"],"award-info":[{"award-number":["24JRRA1087"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation\n                        of China","doi-asserted-by":"crossref","award":["82460178"],"award-info":[{"award-number":["82460178"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Gansu Provincial Department of Education: University Teacher\n                        Innovation Fund Project","award":["2025B-007"],"award-info":[{"award-number":["2025B-007"]}]},{"name":"Key Research and Development Program of Science and Technology\n                        Plan in Gansu Province","award":["25YFFA050"],"award-info":[{"award-number":["25YFFA050"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This cross-sectional study aimed to explore the relationship between thyroid\n                    peroxidase antibody (TPOAb) and osteoporosis, and the moderating effect of\n                    visceral-to-subcutaneous fat area ratio (VSR). A total of 128 males aged over 60\n                    years with normal thyroid function and positive TPOAb (&gt;9 IU\/ml) were\n                    included. Lumbar spine, femoral neck, and whole-body bone mineral density (BMD)\n                    were measured by dual-energy X-ray absorptiometry. Visceral fat area (VFA) and\n                    subcutaneous fat area (SFA) were measured by the Omron DUALSCAN device. The\n                    relationships between TPOAb, VSR, interaction term (VSR*TPOAb) and BMD were\n                    analyzed using multiple linear regression models. Further subgroup analyses were\n                    performed stratified by VSR tertiles. TPOAb showed a significant negative\n                    correlation with BMD in the unadjusted model (p&lt;0.01). However, when adjusted\n                    for confounding covariates, the correlation between TPOAb and BMD was no longer\n                    statistically significant (p&gt;0.05). Further analysis showed VSR and the\n                    interaction term (VSR*TPOAb) were significantly negative associated with BMD in\n                    fully adjusted model (p&lt;0.01). Subgroup analysis, stratified by VSR tertiles,\n                    showed that TPOAb only in T3 group (VSR&gt;0.67) was negatively associated with\n                    lumbar spine and whole-body BMD (p&lt;0.05). Hence, the relationship between\n                    TPOAb and BMD in elderly males varies with VSR. The abnormal body fat\n                    distribution may be a key moderator of the TPOAb-BMD relationship, suggesting\n                    the necessity for personalized bone health monitoring. Specifically, for\n                    patients with VSR&gt;0.67, TPOAb screening is of great significance for the\n                    early prevention of osteoporosis.<\/jats:p>","DOI":"10.1055\/a-2920-5112","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T22:52:08Z","timestamp":1786747928000},"page":"371-379","source":"Crossref","is-referenced-by-count":0,"title":["The Relationship Between TPOAb and Osteoporosis: Moderating Effect of\n                    Visceral-to-Subcutaneous Fat Area Ratio"],"prefix":"10.1055","volume":"58","author":[{"given":"Ying","family":"Yang","sequence":"additional","affiliation":[{"name":"Lanzhou University First Clinical Medical\n                    College, Gansu, China","place":["Lanzhou"],"department":["Lanzhou University First Clinical Medical College"]},{"name":"Lanzhou University First Hospital, Gansu, China","place":["Lanzhou"],"department":["Department of Endocrinology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Tian","sequence":"additional","affiliation":[{"name":"Lanzhou University First Clinical Medical\n                    College, Gansu, China","place":["Lanzhou"],"department":["Lanzhou University First Clinical Medical College"]},{"name":"Lanzhou University First Hospital, Gansu, China","place":["Lanzhou"],"department":["Department of Endocrinology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyun","family":"Li","sequence":"additional","affiliation":[{"name":"Lanzhou University First Clinical Medical\n                    College, Gansu, China","place":["Lanzhou"],"department":["Lanzhou University First Clinical Medical College"]},{"name":"Lanzhou University First Hospital, Gansu, China","place":["Lanzhou"],"department":["Department of Endocrinology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijuan","family":"Guo","sequence":"additional","affiliation":[{"name":"Lanzhou University First Clinical Medical\n                    College, Gansu, China","place":["Lanzhou"],"department":["Lanzhou University First Clinical Medical College"]},{"name":"Lanzhou University First Hospital, Gansu, China","place":["Lanzhou"],"department":["Department of Endocrinology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Bai","sequence":"additional","affiliation":[{"name":"Lanzhou University First Clinical Medical\n                    College, Gansu, China","place":["Lanzhou"],"department":["Lanzhou University First Clinical Medical College"]},{"name":"Lanzhou University First Hospital, Gansu, China","place":["Lanzhou"],"department":["Department of Endocrinology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siwei","family":"Tao","sequence":"additional","affiliation":[{"name":"Lanzhou University First Clinical Medical\n                    College, Gansu, China","place":["Lanzhou"],"department":["Lanzhou University First Clinical Medical College"]},{"name":"Lanzhou University First Hospital, Gansu, China","place":["Lanzhou"],"department":["Department of Endocrinology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2073-4899","authenticated-orcid":false,"given":"Haihong","family":"Lv","sequence":"additional","affiliation":[{"name":"Lanzhou University First Hospital, Gansu, China","place":["Lanzhou"],"department":["Department of Endocrinology"]},{"name":"Lanzhou University First Clinical Medical\n                    College, Gansu, China","place":["Lanzhou"],"department":["Endocrinology"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"108168","DOI":"10.1016\/j.pharmthera.2022.108168","article-title":"Advances in pathogenesis and therapeutic strategies for osteoporosis","volume":"237","author":"S Song","year":"2022","journal-title":"Pharmacol Ther"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e18889","DOI":"10.7717\/peerj.18889","article-title":"Effect of exercise intervention on health-related quality of life in middle-aged\n                    and older people with osteoporosis: a systematic review and meta-analysis","volume":"13","author":"D Geng","year":"2025","journal-title":"PeerJ"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.2147\/TCRM.S518164","article-title":"Causal associations of the alterations in peripheral blood immune 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