{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T23:19:49Z","timestamp":1787786389134,"version":"build-2784847793"},"reference-count":20,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rofo"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This retrospective study evaluated the diagnostic performance of contrast-enhanced ultrasound (CEUS) combined with time-intensity curve (TIC) analysis for differentiating benign from malignant soft tissue lesions.<\/jats:p>\n                  <jats:p>CEUS was performed using a linear transducer (5\u201318 MHz) after a bolus injection of 1.4 \u2013 2.4 ml sulfur hexafluoride microbubbles. Quantitative perfusion parameters including arrival time (AT), time-to-peak (TTP), and area under the curve (AUC) were obtained by system integrated TIC-analysis using intralesional and perilesional regions of interest. Qualitative wash-in and wash-out dynamics were also assessed. Histology, CT and MRI served as reference standards.<\/jats:p>\n                  <jats:p>Ninety lesions were included, comprising 51 benign (lipomas, fibromatoses, inflammatory lesions, lymph nodes and schwannomas) and 39 malignant tumors (sarcomas, lymphomas, metastases). Malignant lesions demonstrated significantly shorter TTP (mean: 15.3 \u00b1 6.6 s vs. 29.8 \u00b1 13.3 s) and a higher prevalence of rapid wash-in (mean: 71.2% vs 13.7%). AT tended to be shorter in malignant lesions. AUC were generally higher in malignant lesions. TIC patterns differed characteristically: benign lesions showed gradual, homogeneous enhancement, whereas malignant tumors exhibited steep early enhancement followed by wash-out.<\/jats:p>\n                  <jats:p>CEUS represents a valuable adjunctive imaging modality for the characterization of soft tissue tumors. Shortened TTP and rapid wash-in\/wash-out represent the most reliable malignancy indicators. Therefore, CEUS may support clinical decision making and biopsy planning.<\/jats:p>","DOI":"10.1055\/a-2923-4597","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T23:04:11Z","timestamp":1787785451000},"source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic Value of Dynamic Contrast Enhanced Ultrasound (CEUS) with Time Intensity Curve (TIC) Analysis for Differentiating Musculoskeletal Benign and Malignant Soft Tissue Tumors"],"prefix":"10.1055","author":[{"given":"Moritz Konstantin","family":"Brandenstein","sequence":"additional","affiliation":[{"name":"University Hospital Regensburg, Germany","place":["Regensburg"],"department":["Department of Radiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Greiner","sequence":"additional","affiliation":[{"name":"University Hospital Regensburg, Germany","place":["Regensburg"],"department":["Department of 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Radiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quirin","family":"Strotzer","sequence":"additional","affiliation":[{"name":"University Hospital Regensburg, Germany","place":["Regensburg"],"department":["Department of Radiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irmgard","family":"Sieber","sequence":"additional","affiliation":[{"name":"Allgemeinarztpraxis Dr. Irmgard Sieber, Germany","place":["Kallm\u00fcnz"],"department":["General practice"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Knott","sequence":"additional","affiliation":[{"name":"University Hospital Regensburg, Germany","place":["Regensburg"],"department":["Department of Radiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinzenz","family":"Mayr","sequence":"additional","affiliation":[{"name":"University Hospital Regensburg, Germany","place":["Regensburg"],"department":["Department of 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