{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T23:27:43Z","timestamp":1786750063817,"version":"build-2736575974"},"reference-count":32,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":44,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AJP Rep"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Objective This study aimed to evaluate the feasibility and temperature stability of low-complexity therapeutic hypothermia (TH) in neonates with moderate-to-severe hypoxic\u2013ischemic encephalopathy (HIE).<\/jats:p>\n                  <jats:p>Study Design Retrospective case series of neonates born at \u226536 weeks of gestation with moderate-to-severe HIE treated with low-complexity TH in a tertiary-level hospital in Peru (2018\u20132024). Variables included timing of initiation, achievement and maintenance of the target core temperature, duration of hypothermia, and clinical outcomes. Descriptive statistics were used.<\/jats:p>\n                  <jats:p>Results A total of 13 neonates were included (77% male; median gestational age 38 weeks). TH was initiated at a median of 103 min after birth. Within the first 6 hours, 84.6% reached 34\u00b0C; however, only 31% maintained a stable core temperature within the target range (33.5\u201334.5\u00b0C) throughout treatment. Median duration of hypothermia was 75 hours. Complications occurred in 23.1% of cases, and overall mortality was 15.4%.<\/jats:p>\n                  <jats:p>Conclusion Low-complexity TH is feasible and allows timely initiation within the neuroprotective window. However, maintaining stable therapeutic temperatures remains a major challenge, which may compromise its potential neuroprotective effectiveness.<\/jats:p>","DOI":"10.1055\/a-2924-5385","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T23:18:14Z","timestamp":1786749494000},"page":"e134-e140","source":"Crossref","is-referenced-by-count":0,"title":["Feasibility and Temperature Stability of Low-Complexity Therapeutic Hypothermia for Neonatal Hypoxic\u2013Ischemic Encephalopathy: A Retrospective Case Series"],"prefix":"10.1055","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3861-6869","authenticated-orcid":false,"given":"Milagros F.","family":"Bermudez-Pelaez","sequence":"additional","affiliation":[{"name":"Universidad Peruana Cayetano Heredia, Lima Region, Peru","place":["San Martin de Porres District"],"department":["Faculty of Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica F.","family":"Rojas-Osorio","sequence":"additional","affiliation":[{"name":"Universidad Peruana Cayetano Heredia, Lima Region, Peru","place":["San Martin de Porres District"],"department":["Faculty of Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian M.","family":"Matos-Inocente","sequence":"additional","affiliation":[{"name":"Universidad Peruana Cayetano Heredia, Lima Region, Peru","place":["San Martin de Porres District"],"department":["Faculty of Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina A.","family":"Bustamante-Ordo\u00f1ez","sequence":"additional","affiliation":[{"name":"Universidad Cientifica del Sur, Peru","place":["Lima Region"],"department":["Faculty of Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria L.","family":"Rospigliosi-Lopez","sequence":"additional","affiliation":[{"name":"Universidad Peruana Cayetano Heredia, Lima Region, Peru","place":["San Martin de Porres District"],"department":["Faculty of Medicine"]},{"name":"Hospital Nacional Cayetano Heredia, Lima Region, Peru","place":["San Martin de Porres District"],"department":["Neonatal Intensive Care Unit"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"ref1","first-page":"217","volume-title":"Handbook of Clinical Neurology","author":"A J Gunn","year":"2019"},{"issue":"06","key":"ref2","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1542\/peds.2014-0899","article-title":"Hypothermia and neonatal encephalopathy","volume":"133","author":"L A Papile","year":"2014","journal-title":"Pediatrics"},{"issue":"03","key":"ref3","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1053\/j.nainr.2011.07.004","article-title":"Hypoxic ischemic encephalopathy: pathophysiology and experimental treatments","volume":"11","author":"K A Allen","year":"2011","journal-title":"Newborn Infant Nurs 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