{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T01:28:25Z","timestamp":1786498105663,"version":"build-2736575974"},"reference-count":33,"publisher":"Georg Thieme Verlag KG","issue":"CP","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The European Microscopic Colitis Group"},{"DOI":"10.13039\/501100009908","name":"Grosserer L. F. Foghts Fond","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009908","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Region Zealand Health Scientific Research Foundation"},{"DOI":"10.13039\/501100009906","name":"Grosserer A.V. Lykfeldt og Hustrus Legat","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009906","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008214","name":"K\u00f8bmand Sven Hansen og Hustru Ina Hansens Fond","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008214","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100010346","name":"Else og Mogens Wedell Wedellsborgs Fond","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010346","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100010344","name":"Aage og Johanne Louis-Hansens Fond","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010344","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100007403","name":"Dagmar Marshalls Fond","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007403","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background and Study Aims Colonoscopy with biopsies is an essential procedure in the diagnostic workup of patients with chronic diarrhea. If the intestinal mucosa appears macroscopically normal or near-normal, tissue samples are retrieved from right and left segments of the colon and sometimes also from the ileum. Biopsies are sent to histologic analysis in individual containers. The aim of this retrospective study was to examine whether the current procedure could be simplified by merging biopsies in one container without affecting the diagnostic quality.<\/jats:p>\n                  <jats:p>Patients\/Materials and Methods Biopsies from patients with an endoscopically normal colon mucosa were included; 250 with a study diagnosis of microscopic colitis (MC) and 233 patients with a study diagnosis of non-MC. H&amp;E-stained microscopy slides from the right and left colon were evaluated by two pathologists, and histologic concordance between the right and left colon was determined.<\/jats:p>\n                  <jats:p>Results In 232 (92.8%) patients with MC and 229 (98.3%) patients with non-MC, the diagnosis was identical in the right and left colon. In six (2.4%) patients from the MC group, biopsies from both segments were within the MC spectrum, while in 12 (4.5%) patients, the histologic characteristics for MC were only fulfilled in one segment of the colon. Biopsies from the ileum were without clinical relevance.<\/jats:p>\n                  <jats:p>Conclusions We suggest merging biopsies from the right and left colon of patients with macroscopically normal mucosa into a single container and refraining from obtaining ileal biopsies when MC is suspected, reducing resource consumption in the endoscopy unit and the pathology department. The results support a transition toward a more sustainable diagnostic procedure.<\/jats:p>","DOI":"10.1055\/a-2926-4399","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T22:50:34Z","timestamp":1785279034000},"source":"Crossref","is-referenced-by-count":0,"special_numbering":"S","title":["Resource Optimization in the Examination of Macroscopic Normal Colon Mucosa"],"prefix":"10.1055","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1852-211X","authenticated-orcid":false,"given":"Kamilla M.B.","family":"Johannesen","sequence":"additional","affiliation":[{"name":"Zealand University Hospital Roskilde, Denmark","place":["Roskilde"],"department":["Department of Pathology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Gravesen","sequence":"additional","affiliation":[{"name":"University of Copenhagen, Denmark","place":["Copenhagen"],"department":["Department of Clinical Medicine"]},{"name":"Herlev Hospital, Capital Region of Denmark, Denmark","place":["Herlev"],"department":["Department of Pathology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Blixt","sequence":"additional","affiliation":[{"name":"Zealand University Hospital Koge, Region Zealand, Denmark","place":["K\u00f8ge"],"department":["Department of Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Cebula","sequence":"additional","affiliation":[{"name":"Zealand University Hospital Nyk\u00f8bing F, Region Zealand, Denmark","place":["Nyk\u00f8bing Falster"],"department":["Department of Internal Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars K.","family":"Munck","sequence":"additional","affiliation":[{"name":"University of Copenhagen, Denmark","place":["Copenhagen"],"department":["Department of Clinical Medicine"]},{"name":"Zealand University Hospital Koge, Region Zealand, Denmark","place":["K\u00f8ge"],"department":["Department of Gastroenterology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Marie K.","family":"Fiehn","sequence":"additional","affiliation":[{"name":"Zealand University Hospital Roskilde, Denmark","place":["Roskilde"],"department":["Department of Pathology"]},{"name":"University of Copenhagen, Denmark","place":["Copenhagen"],"department":["Department of Clinical Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1111\/his.12592","article-title":"Histology of microscopic colitis-review with a practical approach for pathologists","volume":"66","author":"C Langner","year":"2015","journal-title":"Histopathology"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/s41572-021-00273-2","article-title":"Microscopic 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