{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T23:27:58Z","timestamp":1786663678510,"version":"build-2736575974"},"reference-count":42,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Origanum calcaratum is an endemic Greek species found in Cyclades, the Eastern Aegean Sea, and Northeastern Crete. The aim of this study was the thorough phytochemical analysis of O. calcaratum extracts and the in\n                  vitro assessment against cellular senescence. Overall, 27 constituents were identified in methanolic and hydromethanolic extracts by LC\u2013MS and isolation techniques, predominantly phenolic compounds. Both extracts and rosmarinic acid showed noncytotoxicity to healthy cells. In Li\u2013Fraumeni cells, they exhibited concentration-dependent senolytic activity, with rosmarinic acid and the hydromethanolic extract showing significant effects at low concentrations, while the methanolic extract was active only at higher concentrations. These findings highlight the selective senolytic potential of O. calcaratum, particularly the hydromethanolic extract and rosmarinic acid, supporting further investigation as antisenescence agents.<\/jats:p>","DOI":"10.1055\/a-2928-9370","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T22:54:51Z","timestamp":1786661691000},"source":"Crossref","is-referenced-by-count":0,"title":["Phytochemical Investigation of Origanum calcaratum Extracts and in vitro Study against Cellular Senescence"],"prefix":"10.1055","author":[{"given":"Elio Brochsztain","family":"Mizan","sequence":"additional","affiliation":[{"name":"National and Kapodistrian University of Athens, Greece","place":["Athens"],"department":["Section of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, School of Health Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4313-9657","authenticated-orcid":false,"given":"Ekaterina-Michaela","family":"Tomou","sequence":"additional","affiliation":[{"name":"National and Kapodistrian University of Athens, Greece","place":["Athens"],"department":["Section of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, School of Health Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Anagnostou","sequence":"additional","affiliation":[{"name":"National and Kapodistrian University of Athens, Greece","place":["Athens"],"department":["Section of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, School of Health Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Drakopoulou","sequence":"additional","affiliation":[{"name":"National and Kapodistrian University of Athens, Greece","place":["Athens"],"department":["Department of Chemistry"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleftheria","family":"Antaloudaki","sequence":"additional","affiliation":[{"name":"Museum of Crete-University of Crete, Greece","place":["Athens"],"department":["Department of Head of Botany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavlos","family":"Pantelis","sequence":"additional","affiliation":[{"name":"National and Kapodistrian University of Athens (NKUA), Greece","place":["Athens"],"department":["Department of Histology and Embryology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitris-Foivos","family":"Thanos","sequence":"additional","affiliation":[{"name":"National and Kapodistrian University of Athens (NKUA), Greece","place":["Athens"],"department":["Department of Histology and Embryology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassilis G","family":"Gorgoulis","sequence":"additional","affiliation":[{"name":"National and Kapodistrian University of Athens (NKUA), Greece","place":["Athens"],"department":["Department of Histology and Embryology"]},{"name":"University of Dundee, United Kingdom of Great Britain and Northern Ireland","place":["Dundee"],"department":["Ninewells Hospital and Medical School"]},{"name":"University of Manchester, United Kingdom of Great Britain and Northern Ireland","place":["Manchester"],"department":["Faculty Institute for Cancer Sciences"]},{"name":"University of Surrey, United Kingdom of Great Britain and Northern Ireland","place":["Guildford"],"department":["Faculty of Health and Medical Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Thomaidis","sequence":"additional","affiliation":[{"name":"National and Kapodistrian University of Athens, Greece","place":["Athens"],"department":["Department of 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