{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T23:05:09Z","timestamp":1789427109823,"version":"build-2803163510"},"reference-count":36,"publisher":"Georg Thieme Verlag KG","issue":"09","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Hashimoto\u2019s thyroiditis causes cell death, hypothyroidism, and insulin\n                    resistance. Cholecystokinin, orexin-A, and cocaine and amphetamine-regulated\n                    transcript are essential regulators of various endocrine and autonomic\n                    processes, including food intake. We aimed to determine the cocaine and\n                    amphetamine-regulated transcript, orexin-A, and cholecystokinin levels in\n                    Hashimoto's thyroiditis patients and assess the relationships between the\n                    metabolic parameters and Hashimoto's thyroiditis. The present study was\n                    carried out in 45 Hashimoto's thyroiditis patients and 40 healthy control\n                    groups. Serum cocaine and amphetamine-regulated transcript levels\n                    (p&lt;0.05), homeostatic model assessment for insulin resistance\n                        (p&lt;0.05) and body mass index (p&lt;0.05) were significantly\n                    higher in Hashimoto's thyroiditis patients compared to the controls. Serum\n                    orexin-A levels were lower in Hashimoto\u2019s thyroiditis patients than those in the\n                    controls (p&lt;0.05). Serum cholecystokinin levels were similar between\n                    the two groups. A negative correlation was observed between orexin-A levels and\n                    cocaine and amphetamine-regulated transcript and cholecystokinin levels\n                        (r\u2009=\u22120.365, p&lt;0.05; r=\u2212\u20090.297, p&lt;0.05,\n                    respectively). A positive correlation was observed between cocaine and\n                    amphetamine-regulated transcript levels and body mass index, insulin, and\n                    homeostatic model assessment for insulin resistance levels (r=0.448,\n                        p&lt;0.01; r=0.489, p&lt;0.01; r=0.492,\n                    p&lt;0.01, respectively). Increased cocaine and amphetamine-regulated\n                    transcript and decreased orexin-A levels may be involved in the pathogenesis of\n                    Hashimoto\u2019s thyroiditis by controlling the thyroid-dependent immune system,\n                    insulin resistance, appetite, and body weight. We believe that our findings will\n                    lead to new developments in the diagnosis and treatment of this disease.<\/jats:p>","DOI":"10.1055\/a-2930-0189","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T22:46:08Z","timestamp":1787093168000},"page":"364-370","source":"Crossref","is-referenced-by-count":0,"title":["Is Hashimoto\u2019s Thyroiditis Associated with Insulin Resistance\n                    Markers?"],"prefix":"10.1055","volume":"58","author":[{"given":"Ummugulsum","family":"Can","sequence":"additional","affiliation":[{"name":"Konya City Hospital, Konya, Turkey","place":["Konya"],"department":["Department of Biochemistry"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadinaz","family":"Akdu","sequence":"additional","affiliation":[{"name":"Ministry of Health Fethiye State Hospital, Mu\u011fla Province, Turkey","place":["Mugla"],"department":["Biochemistry"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oguzhan","family":"Aksu","sequence":"additional","affiliation":[{"name":"Konya City Hospital, Konya, Turkey","place":["Konya"],"department":["Department of Internal Medicine, Division of Endocrinology and\n                    Metabolism"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hatice","family":"\u00c7al\u0131\u015fkan Burgucu","sequence":"additional","affiliation":[{"name":"Konya City Hospital, Konya, Turkey","place":["Konya"],"department":["Department of Internal Medicine, Division of Endocrinology and\n                    Metabolism"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"issue":"04","key":"ref1","first-page":"696","article-title":"The association of subclinical insulin resistance with thyroid autoimmunity in\n                    euthyroid 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