{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:25:19Z","timestamp":1787271919148,"version":"build-2736575974"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"CP","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ovesco Endoscopy, T\u00fcbingen, Germany"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background and Aims Dumping syndrome (DS) and postbariatric hypoglycemia (PBH) represent common complications after Roux-en-Y gastric bypass (RYGB). Transoral outlet reduction (TORe) addresses the rapid passage of food through the gastrojejunal anastomosis which is central in pathophysiology. In this prospective multicenter study, technical feasibility and short-term clinical efficacy of a new clip-based endoscopic system (BARS) were evaluated.<\/jats:p>\n                  <jats:p>Methods Twenty-three consecutive patients at three centers in Germany were included. The primary endpoint was feasibility measured as reduction of anastomotic diameter and surface. Secondary endpoints included changes of the Dumping symptom score and glycaemia in modified oral glucose tolerance tests (mod. oGTT), anastomotic diameter, quality of life after 12 weeks and adverse events.<\/jats:p>\n                  <jats:p>Results The procedure was technically feasable in all cases. Median anastomotic diameter was reduced from 40 mm (IQR: 30\u201350) to 9 mm (IQR: 7\u201310); \u221277%) at baseline (p &lt; 0.001). At week 12, median Sigstad-Score decreased from 17,5 (IQR: 12.8\u201321.0) to 5 (IQR: 0\u201311; p &lt; 0.001). Median anastomotic diameter was still reduced to 20 mm (IQR: 12\u201330; p = 0.004; \u221247%). Modified oGTT demonstrated abolished DS in 3 of 23 patients (13%) while no effect was seen in PBH at 12 weeks. Median BMI decreased from 30.6 kg\/m2 (IQR: 28\u201335.6) to 29.25 kg\/m2 (IQR: 26.7\u201333.4; p = 0.001). Quality of life (QoL) improved significantly in five of eight subcategories of the SF-36.<\/jats:p>\n                  <jats:p>Conclusion Clip-based anastomotic reduction for DS and PBH seems feasible, safe and showed significant improvements in Sigstad scores and QoL in short-term analysis.<\/jats:p>","DOI":"10.1055\/a-2931-7366","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T23:05:46Z","timestamp":1786057546000},"source":"Crossref","is-referenced-by-count":0,"special_numbering":"S","title":["Clip-Based Endoscopic Anastomotic Reduction in Patients with Dumping Syndrome and Postbariatric Hypoglycemia after Roux-en-Y Gastric Bypass"],"prefix":"10.1055","volume":"14","clinical-trial-number":[{"clinical-trial-number":"drks00022042","registry":"10.18810\/drks"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4831-4194","authenticated-orcid":false,"given":"Armin","family":"Kuellmer","sequence":"additional","affiliation":[{"name":"University of Freiburg Faculty of Medicine, BW, Germany","place":["Freiburg"],"department":["Department of Medicine II, Medical Center"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Kandler","sequence":"additional","affiliation":[{"name":"Dresden City Hospital, SN, Germany","place":["Dresden"],"department":["Department of Gastroenterology and Endoscopy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Nagl","sequence":"additional","affiliation":[{"name":"University Hospital Augsburg, BY, Germany","place":["Augsburg"],"department":["Department of Gastroenterology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Laubner","sequence":"additional","affiliation":[{"name":"University of Freiburg Faculty of Medicine, BW, Germany","place":["Freiburg"],"department":["Division of Endocrinology and Diabetology, Department of Medicine II, Medical Center"]},{"name":"University of Freiburg, BW, Germany","place":["Freiburg"],"department":["Berta-Ottenstein-Programme, Faculty of Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Meyer-Steenbuck","sequence":"additional","affiliation":[{"name":"University of Freiburg Faculty of Medicine, BW, Germany","place":["Freiburg"],"department":["Division of Endocrinology and Diabetology, Department of Medicine II, Medical Center"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4650-2738","authenticated-orcid":false,"given":"Julius","family":"Mueller","sequence":"additional","affiliation":[{"name":"University of Freiburg Faculty of Medicine, BW, Germany","place":["Freiburg"],"department":["Department of Medicine II, Medical Center"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Kaeser","sequence":"additional","affiliation":[{"name":"University of Freiburg Faculty of Medicine, BW, Germany","place":["Freiburg"],"department":["Department of Medicine II, Medical Center"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Sturm","sequence":"additional","affiliation":[{"name":"University of Freiburg Faculty of Medicine, BW, Germany","place":["Freiburg"],"department":["Department of Medicine II, Medical Center"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Seufert","sequence":"additional","affiliation":[{"name":"University of Freiburg Faculty of Medicine, BW, Germany","place":["Freiburg"],"department":["Division of Endocrinology and Diabetology, Department of Medicine II, Medical Center"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Thimme","sequence":"additional","affiliation":[{"name":"University of Freiburg Faculty of Medicine, BW, Germany","place":["Freiburg"],"department":["Department of Medicine II, Medical Center"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Bosch Health Campus, Robert Bosch Hospital, BW, Germany","place":["Stuttgart"],"department":["Department of Gastroenterology, Hepatology, Endocrinology"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1038\/s41574-020-0357-5","article-title":"International consensus on the diagnosis and management of dumping syndrome","volume":"16","author":"E Scarpellini","year":"2020","journal-title":"Nat Rev Endocrinol"},{"issue":"02","key":"ref2","doi-asserted-by":"publisher","first-page":"e3750","DOI":"10.1002\/dmrr.3750","article-title":"Postbariatric surgery hypoglycemia: nutritional, pharmacological and surgical perspectives","volume":"40","author":"G Rossini","year":"2024","journal-title":"Diabetes Metab Res Rev"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1978","DOI":"10.1007\/s11695-016-2266-1","article-title":"Endoluminal revision (OverStitch TM, Apollo Endosurgery) of the dilated Gastroenterostomy in patients with late dumping syndrome after proximal roux-en-Y gastric bypass","volume":"26","author":"C Stier","year":"2016","journal-title":"Obes Surg"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.gie.2020.02.029","article-title":"Endoscopic management of dumping syndrome after roux-en-Y gastric bypass: a large international series and proposed management strategy","volume":"92","author":"E J Vargas","year":"2020","journal-title":"Gastrointest Endosc"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"6846","DOI":"10.1007\/s00464-020-08190-3","article-title":"Endoscopic trans-oral outlet reduction after bariatric surgery is safe and effective for dumping 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