{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T23:27:11Z","timestamp":1787182031850,"version":"build-2736575974"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ultraschall Med"],"abstract":"<jats:p>Abstract: \nPurpose: To describe associated anomalies and outcomes of prenatally diagnosed Ebstein\u2019s anomaly (EA)\/tricuspid valve dysplasia (TVD) in a multicenter cohort and to identify predictors of adverse outcome (intrauterine or postnatal death).\nMaterials and Methods: In this retrospective study, cardiothoracic ratio, aortic valve diameter (AVD), pulmonary and atrioventricular valve measurements, ventricular dimensions, vena contracta, chamber areas, Celemajer index, peak tricuspid regurgitation velocity (TR_max), and pulmonary flow direction between survivors and non-survivors were compared across three gestational intervals.\nResults: Among 87 fetuses, 7 (8.0%) intrauterine deaths and 7 (8.0%) terminations occurred; 14 (16.1%) were lost to follow-up. Fifty-nine (67.8%) live births with follow-up were documented; 52 (88.1%) underwent active postnatal management, with a survival rate of 69.2% (36\/52). Non-survivors more frequently had hydrops, earlier delivery, and lower birth weight. z-score AVD (zAVD) was lower and pulmonary flow more often retrograde in non-survivors before 32 weeks. TR_max was lower in interval 1 (&lt;24 weeks), and right atrial area and vena contracta were larger in interval 2 (24\u201332 weeks). No significant differences were observed after 32 weeks.\nConclusion: This is one of the largest prenatal multicenter cohorts employing a longitudinal design, with echocardiographic data evaluation across three gestational intervals. Established predictors (pulmonary flow, TR_max) were confirmed and zAVD was identified as a simple, clinically applicable parameter, highlighting the relevance of left ventricular involvement in EA\/TVD.\n\nZusammenfassung: \nZiel: Ziel dieser retrospektiven, multizentrischen Studie war es, assoziierte Anomalien und das Outcome bei pr\u00e4natal diagnostizierter Ebstein-Anomalie \/Trikuspidalklappendysplasie (EA\/TVD)   zu analysieren sowie Pr\u00e4diktoren f\u00fcr ein ung\u00fcnstiges Outcome (intrauteriner Fruchttod (IUFT), postnataler Tod) zu identifizieren.\nMaterial und Methoden: Retrospektiv wurden kardiothorakale Ratio, Aortenklappendurchmesser (AVD), pulmonale und atrioventrikul\u00e4re Klappen, Ventrikeldimensionen, Vena contracta, Vorhof-\/Ventrikelfl\u00e4chen, Celemajer-Index, maximale Trikuspidalinsuffizienzgeschwindigkeit (TR_max) und Pulmonalflussrichtung zwischen \u00dcberlebenden und Nicht-\u00dcberlebenden in drei3 Gestationsintervallen verglichen.\nErgebnisse: Von 87 Feten traten 7 (8,0%) IUFT auf, 7 (8,0%)  Schwangerschaftsabbr\u00fcche erfolgten, 14 (16,1%) waren lost to follow-up. Insgesamt wurden 59\/87 (67,8%) Lebendgeburten dokumentiert; 52 (88,1%) erhielten ein aktives postnatales Management mit einer \u00dcberlebensrate von 69,2% (36\/52). Nicht-\u00dcberlebende zeigten h\u00e4ufiger Hydrops, fr\u00fchere Entbindung und geringeres Geburtsgewicht. Der Z-Score des AVD (zAVD) war &lt;32 Wochen niedriger, der Pulmonalfluss h\u00e4ufiger retrograd.  TR_max war  &lt;24 Wochen niedriger,  rechte Vorhoffl\u00e4che und Vena contracta zwischen 24\u201332 Wochen gr\u00f6\u00dfer. Nach 32 Wochen bestanden keine signifikanten Unterschiede.\nSchlussfolgerung: : Dies ist eine der gr\u00f6\u00dften pr\u00e4natalen, multizentrischen Kohorten mit longitudinaler Auswertung \u00fcber drei3 Gestationsintervalle. Etablierte Pr\u00e4diktoren (Pulmonalfluss, TR_max) wurden best\u00e4tigt, und zAVD als einfacher, klinisch anwendbarer Parameter identifiziert, der die Relevanz der linksventrikul\u00e4ren Beteiligung bei EA\/TVD unterstreicht.<\/jats:p>","DOI":"10.1055\/a-2932-8445","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T23:23:31Z","timestamp":1787181811000},"source":"Crossref","is-referenced-by-count":0,"title":["Prenatally diagnosed Ebstein\u2019s anomaly and tricuspid valve dysplasia: associated anomalies and predictors of outcome in a multicenter cohort study"],"prefix":"10.1055","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9796-517X","authenticated-orcid":false,"given":"Aline","family":"Wolter","sequence":"additional","affiliation":[{"name":"Justus-Liebig-University, Gie\u00dfen and University Hospital, Gie\u00dfen & Marburg, Campus Gie\u00dfen, Germany","place":["Gie\u00dfen"],"department":["Department of Obstetrics and Gynaecology, Division of Prenatal Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Ritz","sequence":"additional","affiliation":[{"name":"Justus-Liebig-University, Gie\u00dfen and University Hospital, Gie\u00dfen & Marburg, Campus Gie\u00dfen, Germany","place":["Gie\u00dfen"],"department":["Department of Obstetrics and Gynaecology, Division of Prenatal Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Sebastian","family":"Wolter","sequence":"additional","affiliation":[{"name":"Kerckhoff Heart and Thorax Center, Germany","place":["Bad Nauheim"],"department":["Department of Cardiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrii","family":"Kurkevych","sequence":"additional","affiliation":[{"name":"Ukrainian Children's Hospital Kyiv, Ukraine","place":["Kyiv"],"department":["Fetal Cardiology Unit"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Thul","sequence":"additional","affiliation":[{"name":"Justus-Liebig-University, Gie\u00dfen and University Hospital, Gie\u00dfen & Marburg, Campus Gie\u00dfen, Germany","place":["Gie\u00dfen"],"department":["Department of Paediatric Cardiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivonne","family":"Bedei","sequence":"additional","affiliation":[{"name":"Justus-Liebig-University, Gie\u00dfen and University Hospital, Gie\u00dfen & Marburg, Campus Gie\u00dfen, Germany","place":["Gie\u00dfen"],"department":["Department of Obstetrics and Gynaecology, Division of Prenatal Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Schenk","sequence":"additional","affiliation":[{"name":"Justus-Liebig-University, Gie\u00dfen and University Hospital, Gie\u00dfen & Marburg, Campus Gie\u00dfen, Germany","place":["Gie\u00dfen"],"department":["Department of Obstetrics and Gynaecology, Division of Prenatal Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4817-3368","authenticated-orcid":false,"given":"Josefine Theresia","family":"K\u00f6nigbauer","sequence":"additional","affiliation":[{"name":"Charit\u00e9 University, Germany","place":["Berlin"],"department":["Department of Obstetrics"]},{"name":"Prenatal Medicine Bergmannstra\u00dfe, Germany","place":["Berlin"],"department":["Prenatal Diagnostic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5131-7372","authenticated-orcid":false,"given":"Alexander","family":"Weichert","sequence":"additional","affiliation":[{"name":"Charit\u00e9 University, Germany","place":["Berlin"],"department":["Department of Obstetrics"]},{"name":"Prenatal Medicine Bergmannstra\u00dfe, Germany","place":["Berlin"],"department":["prenatal diagnostic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Axt-Fliedner","sequence":"additional","affiliation":[{"name":"Justus-Liebig-University, Gie\u00dfen and University Hospital, Gie\u00dfen & Marburg, Campus Gie\u00dfen, Germany","place":["Gie\u00dfen"],"department":["Department of Obstetrics and Gynaecology, Division of Prenatal Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","container-title":["Ultraschall in der Medizin - European Journal of Ultrasound"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2932-8445.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T23:23:31Z","timestamp":1787181811000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2932-8445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,19]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1055\/a-2932-8445","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0172-4614","1438-8782"],"issn-type":[{"value":"0172-4614","type":"print"},{"value":"1438-8782","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,8,19]]},"published":{"date-parts":[[2026,8,19]]}}}