{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:23:20Z","timestamp":1787271800764,"version":"build-2736575974"},"reference-count":62,"publisher":"Georg Thieme Verlag KG","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020891","name":"Professional Staff Congress \u2014 The City University of New York","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100020891","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["NIH-R16G149468"],"award-info":[{"award-number":["NIH-R16G149468"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Aconitum species have been used as traditional medicines in Asian countries for millennia, and contain well-characterized bioactive diterpenoid alkaloids. In contrast, American Aconitum species have been less studied, despite their close phylogenetical relationship to the important Asian medicinal species. This study aims to investigate the chemistry and bioactivity of American Aconitum, since they also produce diterpenoid alkaloids that possess toxicity. The chemical profiles of three American Aconitum species, A. delphiniifolium, A. columbianum, and A. uncinatum, and their four individual plant parts (roots, stems, leaves, and flowers) were studied using UPLC-qTof-MSe technique, and compared to Asian and European species. Multivariate including principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA) were used to analyze the chemical profiles. PCA suggests that American Aconitum is more chemically similar to Asian than European species. Using OPLS-DA, 29 unique marker compounds were found in American Aconitum, but not in the Asian or European species, we studied. Nineteen marker compounds were tentatively identified using Progenesis Qi and reference standards, including proved analgesic compounds such as talatisamine and 14-benzoyltalatisamine as well as other bioactive compounds. The results suggest that American Aconitum is a potential source for lead drugs. The cardiotoxicity of American Aconitum root extracts (200 \u03bcg\/mL) was assessed using a zebrafish embryo model, and compared to the most widely used Asian species, A. carmichaelii. Aconitum delphiniifolium did not show any cardiotoxicity in this zebrafish model, as compared to A. carmichaelii and the control compound, aconitine. However, A. columbianum and A. uncinatum induced some morphological heart differences but not as profoundly as A. carmichaelii.<\/jats:p>","DOI":"10.1055\/a-2933-1425","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T23:25:52Z","timestamp":1787268352000},"source":"Crossref","is-referenced-by-count":0,"title":["Metabolomic and Cardiotoxicity Analyses of American Aconitum Compared to Related Asian and European Species"],"prefix":"10.1055","author":[{"given":"Yi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Lehman College, City University of New York, Bronx, United States","place":["New York"],"department":["Department of Biological Sciences"]},{"name":"The Graduate Center, City University of New York, New York, United States","place":["New York"],"department":["Ph.D. Program in Biology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalia G.","family":"Holtzman","sequence":"additional","affiliation":[{"name":"The Graduate Center, City University of New York, New York, United States","place":["New York"],"department":["Ph.D. Program in Biology"]},{"name":"Queens College, City University of New York, Queens, United States","place":["New York"],"department":["Department of Biology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward J.","family":"Kennelly","sequence":"additional","affiliation":[{"name":"Lehman College, City University of New York, Bronx, United States","place":["New York"],"department":["Department of Biological Sciences"]},{"name":"The Graduate Center, City University of New York, New York, United States","place":["New York"],"department":["Ph.D. Program in Biology"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/jphp.12310","article-title":"A review on phytochemistry, pharmacology and toxicology studies of Aconitum","volume":"67","author":"E Nyirimigabo","year":"2015","journal-title":"J Pharm Pharmacol"},{"issue":"01","key":"ref2","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.jep.2009.07.031","article-title":"Aconitum in traditional Chinese medicine\u2014a valuable drug or an unpredictable risk?","volume":"126","author":"J Singhuber","year":"2009","journal-title":"J Ethnopharmacol"},{"issue":"07","key":"ref3","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/S1875-5364(21)60050-X","article-title":"A systematic review of pharmacological activities, toxicological mechanisms and pharmacokinetic studies on Aconitum alkaloids","volume":"19","author":"L Mi","year":"2021","journal-title":"Chin J Nat Med"},{"issue":"08","key":"ref4","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1016\/j.phytochem.2005.02.010","article-title":"Alkaloids of Aconitum laeve and their anti-inflammatory, antioxidant and tyrosinase inhibition activities","volume":"66","author":"F Shaheen","year":"2005","journal-title":"Phytochemistry"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.jhazmat.2011.11.029","article-title":"Establishment of a bioassay for the toxicity evaluation and quality control of Aconitum herbs","volume":"199\u2013200","author":"Y Qin","year":"2012","journal-title":"J Haz Mat"},{"issue":"29","key":"ref6","doi-asserted-by":"publisher","first-page":"15625","DOI":"10.1021\/acs.analchem.5c00249","article-title":"Monitoring the chemical transformation and detoxification process of Aconitum herbs during processing by maximum-quantum filter NMR spectroscopy","volume":"97","author":"H Jiang","year":"2025","journal-title":"Anal Chem"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0378-8741(91)90141-Y","article-title":"The medicinal flora of native North America","volume":"31","author":"D Moerman","year":"1991","journal-title":"J Ethnopharmacol"},{"issue":"1\/2","key":"ref8","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s00606-004-0257-5","article-title":"Phylogeny of Aconitum subgenus Aconitum (Ranunculaceae) inferred from ITS sequences","volume":"252","author":"Y Luo","year":"2005","journal-title":"Plant Syst Evol"},{"key":"ref9","volume-title":"Pharmacopoeia of the People\u2019s Republic of China","author":"State Pharmacopoeia Commission of P.R. 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