{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T23:20:04Z","timestamp":1788477604240,"version":"build-2803163510"},"reference-count":64,"publisher":"Georg Thieme Verlag KG","issue":"CP","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TH Open"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Abdominal Aortic Aneurysm (AAA) is characterized by persistent inflammation, extracellular matrix loss, and intraluminal thrombus formation, yet the genetic links among these processes remain incompletely defined. Here, we examine evidence that genetic variation can influence inflammatory and thrombotic responses at the same time. Findings from genome-wide association studies are considered alongside transcriptomic, proteomic, single-cell, epigenetic, and experimental data. Particular attention is given to candidate genes and signaling networks relevant to AAA susceptibility, enlargement, and rupture. The available evidence supports a model in which inherited susceptibility alters the balance between vascular inflammation, coagulation, fibrinolysis, and wall repair. However, many reported loci still lack functional confirmation, and most genetic data come from populations of European ancestry. Defining the causal variants and the cells in which they act will be necessary before these findings can be used for individualized screening or treatment.<\/jats:p>","DOI":"10.1055\/a-2936-0175","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T23:08:56Z","timestamp":1788476936000},"source":"Crossref","is-referenced-by-count":0,"special_numbering":"S","title":["The Inflammation\u2013Thrombosis Genetic Axis in Abdominal Aortic Aneurysm: A Shared Roadmap to Precision Medicine"],"prefix":"10.1055","volume":"10","author":[{"given":"Yanfei","family":"Yang","sequence":"first","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","department":["Department of Vascular Surgery, Peking Union Medical College Hospital"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhang","family":"Liu","sequence":"first","affiliation":[{"name":"School of Basic Medical Sciences, Dalian Medical University, Liaoning, China","place":["Dalian"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0390-623X","authenticated-orcid":false,"given":"Yuexin","family":"Chen","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China","department":["Department of Vascular Surgery, Peking Union Medical College Hospital"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"101682","DOI":"10.1016\/j.jacadv.2025.101682","article-title":"Pathobiology of aortic aneurysms and dissections: synthesis of recent investigations and evolving insights","volume":"4","author":"L M Buja","year":"2025","journal-title":"JACC 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