{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T23:20:48Z","timestamp":1787872848059,"version":"build-2784847793"},"reference-count":22,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Transanal endoscopic surgery (TES) and endoscopic submucosal dissection (ESD) are established organ-preserving approaches, but comparative randomized evidence remains limited. This meta-analysis of randomized controlled trials (RCTs) compared TES and ESD in rectal neoplasms.<\/jats:p>\n                  <jats:p>Multiple databases were searched from inception through to 29 March 2026. Outcomes of interest included en bloc resection, R0 resection, adverse events, procedure time, recurrence, and hospital stay. Risk ratios (RRs) with 95%CIs were calculated using a random-effects model.<\/jats:p>\n                  <jats:p>Five RCTs with 624 patients (TES 307, ESD 317) were included. No statistically significant differences were observed in en bloc resection (RR 1.02, 95%CI 0.95 to 1.10; P = 0.55; I\n                  2 = 73%), R0 resection (RR 1.00, 95%CI 0.90 to 1.10; P = 0.95; I\n                  2 = 60%), recurrence (RR 1.73, 95%CI 0.53 to 5.67; P = 0.36; I\n                  2 = 6%), bleeding (RR 0.50, 95%CI 0.10 to 2.63; P = 0.41; I\n                  2 = 68%), perforation (RR 0.22, 95%CI 0.01 to 4.49; P = 0.33), or hospital stay (mean difference [MD] 0.57 days, 95%CI \u22120.52 to 1.67; P = 0.30; I\n                  2 = 94%) between the TES and ESD approaches. TES had a shorter procedure time compared with ESD (MD \u221221.93 minutes, 95%CI \u221228.22 to \u221215.64; P &lt; 0.001; I\n                  2 = 52%). Trial sequential analysis for bleeding, perforation, and recurrence found cumulative Z curves crossed neither monitoring boundaries nor the diversity-adjusted required information size, leaving the evidence inconclusive.<\/jats:p>\n                  <jats:p>This meta-analysis of RCTs found no statistically significant differences between ESD and TES for short-term oncologic outcomes in selected rectal neoplasms; the certainty of the evidence was very low for these outcomes.<\/jats:p>","DOI":"10.1055\/a-2936-0686","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:41:31Z","timestamp":1786495291000},"source":"Crossref","is-referenced-by-count":0,"title":["Endoscopic submucosal dissection versus transanal endoscopic surgery in rectal neoplasms: meta-analysis of randomized controlled trials and trial sequential analysis"],"prefix":"10.1055","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8752-4867","authenticated-orcid":false,"given":"Aamir","family":"Saeed","sequence":"additional","affiliation":[{"name":"University of Tennessee Health Sciences Center, College of Medicine, Tennessee, United States","place":["Memphis"],"department":["Division of Gastroenterology and Hepatology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard","family":"Baidoo","sequence":"additional","affiliation":[{"name":"University of Tennessee Health Sciences Center, College of Medicine, Tennessee, United States","place":["Memphis"],"department":["Division of Gastroenterology and Hepatology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hina","family":"Akbar","sequence":"additional","affiliation":[{"name":"King Edward Medical College, Punjab, Pakistan","place":["Lahore"],"department":["Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6842-506X","authenticated-orcid":false,"given":"Faisal","family":"Kamal","sequence":"additional","affiliation":[{"name":"Thomas Jefferson University, Pennsylvania, United States","place":["Philadelphia"],"department":["Division of Gastroenterology and Hepatology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Radlinski","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center, Tennessee, United States","place":["Nashville"],"department":["Division of Gastroenterology and Hepatology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio A.","family":"Tombazzi","sequence":"additional","affiliation":[{"name":"University of Tennessee Health Sciences Center, College of Medicine, Tennessee, United States","place":["Memphis"],"department":["Division of Gastroenterology and Hepatology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansour A.","family":"Parsi","sequence":"additional","affiliation":[{"name":"Medical University of South Carolina, South Carolina, United States","place":["Charleston"],"department":["Division of Gastroenterology and Hepatology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sultan","family":"Mahmood","sequence":"additional","affiliation":[{"name":"University of Pittsburgh Medical Center Health System, Pennsylvania, United States","place":["Pittsburgh"],"department":["Division of Gastroenterology and Hepatology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3038-4669","authenticated-orcid":false,"given":"Dennis","family":"Yang","sequence":"additional","affiliation":[{"name":"AdventHealth Orlando, Florida, United States","place":["Orlando"],"department":["Center for Interventional Endoscopy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Draganov","sequence":"additional","affiliation":[{"name":"University of Florida, Florida, United States","place":["Gainesville"],"department":["Division of Gastroenterology and Hepatology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maham","family":"Hayat","sequence":"additional","affiliation":[{"name":"AdventHealth Orlando, Florida, United States","place":["Orlando"],"department":["Center for Interventional Endoscopy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"229","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"F Bray","year":"2024","journal-title":"CA Cancer J 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