{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:19:29Z","timestamp":1787959169686,"version":"build-2784847793"},"reference-count":33,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background: The significance of muscle\u2013bone interactions in bone\n                    metabolism and the pathophysiology of osteoporosis has been recognized. However,\n                    the effects of thyroid hormones on muscle\u2013bone interactions remain unclear.<\/jats:p>\n                  <jats:p>Methods: We herein investigated the effects of hyperthyroidism on muscle\n                    and bone by administering L-thyroxin to male mice for 4 weeks.<\/jats:p>\n                  <jats:p>Results: A micro-computed tomography analysis showed that the\n                    administration of L-thyroxin significantly decreased trabecular bone mineral\n                    density, bone volume\/tissue volume, trabecular number, trabecular thickness, and\n                    connectivity density at the femurs of mice and slightly reduced cortical\n                    thickness. However, the administration of L-thyroxin did not affect muscle mass\n                    in the lower limbs, tissue weights of the soleus and gastrocnemius muscles, or\n                    grip strength. Among the myokines examined, the administration of L-thyroxin\n                    significantly decreased the messenger RNA level of follistatin in the soleus\n                    muscle and simple regression analyses showed a positive correlation between\n                    follistatin levels and bone volume\/tissue volume; however, it did not affect\n                    serum follistatin levels.<\/jats:p>\n                  <jats:p>Conclusions: The present results suggest that hyperthyroidism induced by\n                    the administration of L-thyroxin caused trabecular-dominant osteopenia without\n                    reducing muscle mass or grip strength in mice. The direct effects of thyroid\n                    hormones on bone, but not muscle\u2013bone interactions, may be crucial for\n                    hyperthyroidism-induced osteoporosis.<\/jats:p>","DOI":"10.1055\/a-2937-4838","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T22:56:17Z","timestamp":1787957777000},"source":"Crossref","is-referenced-by-count":0,"title":["Effects of thyroid hormones on muscle and bone in\n                    mice"],"prefix":"10.1055","author":[{"given":"Akihito","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"Kindai University, Osaka Prefecture, Japan","place":["Sakai"],"department":["Faculty of Medicine, Department of Orthopaedic Surgery"]},{"name":"Kindai University, Osaka Prefecture, Japan","place":["Sakai"],"department":["Faculty of Medicine, Department of Physiology and Regenerative Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoyuki","family":"Kawao","sequence":"additional","affiliation":[{"name":"Kindai University, Osaka Prefecture, Japan","place":["Sakai"],"department":["Faculty of Medicine, Department of Physiology and Regenerative Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuya","family":"Mizukami","sequence":"additional","affiliation":[{"name":"Kindai University, Osaka Prefecture, Japan","place":["Sakai"],"department":["Faculty of Medicine, Department of Physiology and Regenerative Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryota","family":"Kishigami","sequence":"additional","affiliation":[{"name":"Kindai University, Osaka Prefecture, Japan","place":["Sakai"],"department":["Faculty of Medicine, Department of Physiology and Regenerative Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Goto","sequence":"additional","affiliation":[{"name":"Kindai University, Osaka Prefecture, Japan","place":["Sakai"],"department":["Faculty of Medicine, Department of Orthopaedic Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7433-5135","authenticated-orcid":false,"given":"Hiroshi","family":"Kaji","sequence":"additional","affiliation":[{"name":"Kindai University, Osaka Prefecture, Japan","place":["Sakai"],"department":["Faculty of Medicine, Department of Physiology and Regenerative Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.abb.2010.06.021","article-title":"Thyroid and bone","volume":"503","author":"A I Gogakos","year":"2010","journal-title":"Arch Biochem 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Tsourdi","year":"2019","journal-title":"Endocrinology"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"R57","DOI":"10.1530\/JOE-16-0611","article-title":"Role of thyroid hormone in skeletal muscle physiology","volume":"236","author":"F F Bloise","year":"2018","journal-title":"J Endocrinol"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1603560","article-title":"Association between free T\n               3 and sarcopenia in euthyroid older\n                    patients with Hashimoto\u2019s thyroiditis","volume":"16","author":"J L Chen","year":"2025","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-25-0203","article-title":"Thyroxine does not improve skeletal muscle regeneration after injury in aged\n                    mice","volume":"267","author":"T S Oliveira","year":"2025","journal-title":"J 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Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2937-4838.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T22:56:17Z","timestamp":1787957777000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2937-4838"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,28]]},"references-count":33,"URL":"https:\/\/doi.org\/10.1055\/a-2937-4838","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0947-7349","1439-3646"],"issn-type":[{"value":"0947-7349","type":"print"},{"value":"1439-3646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,28]]}}}