{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T23:08:58Z","timestamp":1788822538846,"version":"build-2803163510"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","funder":[{"name":"InLife Institute of Animal Reproduction and Food Research,\n                        Polish Academy of Sciences, Olsztyn, Poland","award":["Research fund"],"award-info":[{"award-number":["Research fund"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Introduction Skeletal muscle is an essential tissue for insulin-stimulated\n                    glucose uptake. Myokines are proteins, peptides, and other metabolites that are\n                    released by muscles and exhibit metabolic functions. Decorin, apelin and\n                        TRIM72 are myokines with connection to an insulin action. The aim of\n                    this article was to study the expression of these selected myokines in skeletal\n                    muscle in relation to insulin sensitivity in individuals without overt metabolic\n                    disturbances.<\/jats:p>\n                  <jats:p>Methods Thirty healthy young male volunteers with normal glucose\n                    tolerance, 14 normal-weight, 8 with overweight and 8 with obesity, were included\n                    in the study population. The vastus lateralis muscle biopsies were performed.\n                    Insulin sensitivity was tested with hyperinsulinemic\u2013euglycemic clamp. Muscle\n                    tissue messenger RNA expression was assessed via a quantitative polymerase chain\n                    reaction.<\/jats:p>\n                  <jats:p>Results Group consisting of individuals with obesity had lower insulin\n                    sensitivity compared to those with normal weight and overweight. Apelin\n                    expression was significantly higher in the obese group compared to the\n                    normal-weight and overweight groups. All myokines\u2019 expressions correlated with\n                    insulin sensitivity: decorin \u2013 positively and apelin and TRIM72 \u2013\n                    negatively. Only apelin was correlated positively with body mass index. Apelin\n                    was correlated with insulin sensitivity independently of body mass index,\n                    decorin was also correlated with insulin sensitivity independently of body mass\n                    index.<\/jats:p>\n                  <jats:p>Conclusion Apelin, decorin and TRIM72 are correlated with insulin\n                    sensitivity and decorin and apelin have body mass index-independent\n                    associations. This suggests that these molecules can be linked to metabolic\n                    health.<\/jats:p>","DOI":"10.1055\/a-2937-4910","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T23:49:15Z","timestamp":1787269755000},"source":"Crossref","is-referenced-by-count":0,"title":["Skeletal Muscle Decorin, Apelin and TRIM72 Gene Expression in\n                    Relation to Insulin Sensitivity"],"prefix":"10.1055","author":[{"given":"Dominika","family":"Szutko","sequence":"additional","affiliation":[{"name":"InLife Institute of Animal Reproduction and Food Research, Poland","place":["Bialystok"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9274-7984","authenticated-orcid":false,"given":"Marek","family":"Straczkowski","sequence":"additional","affiliation":[{"name":"InLife Institute of Animal Reproduction and Food Research, Poland","place":["Bialystok"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4093\/dmj.2021.0280","article-title":"Insulin resistance: From mechanisms to therapeutic strategies","volume":"46","author":"S H Lee","year":"2022","journal-title":"Diabetes Metab J"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/s41392-024-01951-9","article-title":"Type 2 diabetes mellitus in adults: Pathogenesis, prevention and\n                    therapy","volume":"9","author":"X Lu","year":"2024","journal-title":"Signal Transduction Targeted Ther"},{"key":"ref3","first-page":"1","article-title":"The role of exercise in the interplay between myokines, hepatokines, osteokines,\n                    adipokines, and modulation of inflammation for energy substrate redistribution\n                    and fat mass loss: A review","volume":"12","author":"A M Gonzalez-Gil","year":"2020","journal-title":"Nutrients"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1377025","DOI":"10.3389\/fphys.2024.1377025","article-title":"MG53\/TRIM72: multi-organ repair protein and beyond","volume":"15","author":"Y F Wang","year":"2024","journal-title":"Front Physiol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"145","DOI":"10.2337\/db24-0556","article-title":"Friend or foe: The paradoxical roles of MG53 in diabetes","volume":"74","author":"S Yuan","year":"2025","journal-title":"Diabetes"},{"issue":"02","key":"ref6","doi-asserted-by":"crossref","first-page":"786","DOI":"10.3390\/ijms23020786","article-title":"Metabolic syndrome: Updates on pathophysiology and management in\n                    2021","volume":"23","author":"G Fahed","year":"2022","journal-title":"Int J Mol Sci"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"81","DOI":"10.14740\/jem876","article-title":"Serum apelin level in type 2 diabetic mellitus patients and its association with\n                    metabolic syndrome components","volume":"13","author":"HA H Saadi","year":"2023","journal-title":"J Endocrinol Metab"},{"issue":"01","key":"ref8","first-page":"7","article-title":"Elevated serum apelin, insulin, and IL-17 levels in middle-aged\n                    patients with type 2 diabetes mellitus: Associations with hepatic enzyme\n                    alterations","volume":"6","author":"S Khlaif Mansoor","year":"2024","journal-title":"Central Asian Journal of Theoretical and Applied\n                    Science"},{"issue":"07","key":"ref9","doi-asserted-by":"publisher","first-page":"719","DOI":"10.35975\/apic.v29i7.2966","article-title":"Comparative analysis of apelin levels in type 2 diabetes mellitus among the\n                    obese and non-obese population of Karachi, Pakistan","volume":"29","author":"S Rehman","year":"2025","journal-title":"Anaesth, Pain Intensive Care"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"e14267","DOI":"10.1111\/apha.14267","article-title":"DECORIN, a triceps-derived myokine, protects sorted \u03b2-cells and human\n                    islets against chronic inflammation associated with type 2 diabetes","volume":"241","author":"A Langlois","year":"2025","journal-title":"Acta Physiologica"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"479258","DOI":"10.3389\/fendo.2020.479258","article-title":"Cardioprotective effect of decorin in type 2 diabetes","volume":"11","author":"F Chen","year":"2020","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"07","key":"ref12","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.21123\/2411-7986.4984","article-title":"Assessment of decorin level and some biochemical parameters in iraqi patients\n                    with diabetic nephropathy","volume":"22","author":"Z M Ismail","year":"2025","journal-title":"Baghdad Science Journal"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3389\/fphys.2020.00091","article-title":"Exercise-released myokines in the control of energy metabolism","volume":"11","author":"C Laurens","year":"2020","journal-title":"Front Physiol"},{"issue":"03","key":"ref14","doi-asserted-by":"publisher","DOI":"10.1093\/lifemeta\/loae006","article-title":"Myokines: Metabolic regulation in obesity and type 2 diabetes","volume":"3","author":"Z-T Chen","year":"2024","journal-title":"Life Metabolism"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"358","DOI":"10.2337\/dc11-1295","article-title":"Circulating brain-derived neurotrophic factor concentration is downregulated by\n                    intralipid\/heparin infusion or high-fat meal in young healthy male subjects","volume":"35","author":"M Karczewska-Kupczewska","year":"2012","journal-title":"Diabetes Care"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1016\/j.bbrc.2014.06.123","article-title":"The myokine decorin is regulated by contraction and involved in muscle\n                    hypertrophy","volume":"450","author":"T Kanzleiter","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.tem.2015.05.006","article-title":"The extracellular matrix and insulin resistance","volume":"26","author":"A S Williams","year":"2015","journal-title":"Trends in Endocrinol Metabo"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"e150","DOI":"10.1111\/j.1600-0838.2011.01414.x","article-title":"Expression of extracellular matrix\n                    components and related growth factors in human tendon and muscle after acute\n                    exercise","volume":"23","author":"K M Heinemeier","year":"2013","journal-title":"Scand J Med Sci Sports"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/346281a0","article-title":"Negative regulation of transforming growth factor-\u03b2 by the proteoglycan\n                    decorin","volume":"346","author":"Y Yamaguchi","year":"1990","journal-title":"Nature"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/s12079-009-0066-2","article-title":"The matricellular functions of small leucine-rich proteoglycans (SLRPs)","volume":"3","author":"R Merline","year":"2009","journal-title":"J Cell Commun Signal"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"e70424","DOI":"10.14814\/phy2.70424","article-title":"The proteoglycan decorin does not influence adiposity, glucose\n                    tolerance, or aerobic exercise capacity in mice","volume":"13","author":"C L Egan","year":"2025","journal-title":"Physiol Rep"},{"issue":"04","key":"ref22","doi-asserted-by":"publisher","first-page":"1764","DOI":"10.1210\/en.2004-1427","article-title":"Apelin, a newly identified adipokine up-regulated by insulin and obesity","volume":"146","author":"J Boucher","year":"2005","journal-title":"Endocrinology"},{"issue":"05","key":"ref23","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.tem.2012.02.005","article-title":"Apelin, a promising target for type 2 diabetes treatment?","volume":"23","author":"I Castan-laurell","year":"2012","journal-title":"Trends in Endocrinol Metab"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.21608\/ejhm.2022.227708","article-title":"Cross-positive correlation between d talk between apelin, insulin resistance,\n                    thyroid hormones, and cardio-metabolic risk factors in polycystic ovary\n                    syndrome","volume":"87","author":"R Abdelshaheed Matta","year":"2022","journal-title":"Egypt J Hosp Med"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.cmet.2008.10.003","article-title":"Apelin stimulates glucose utilization in normal and obese insulin-resistant\n                    mice","volume":"8","author":"C Dray","year":"2008","journal-title":"Cell Metab"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1124\/mol.117.108241","article-title":"MG53: Biological function and potential as a therapeutic target","volume":"92","author":"Y Zhang","year":"2017","journal-title":"Mol Pharmacol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"2354","DOI":"10.1038\/ncomms3354","article-title":"MG53-induced IRS-1 ubiquitination negatively regulates skeletal\n                    myogenesis and insulin signalling","volume":"4","author":"J S Yi","year":"2013","journal-title":"Nat Commun"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1038\/nature11834","article-title":"Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic\n                    disorders","volume":"494","author":"R Song","year":"2013","journal-title":"Nature"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1161\/CIRCULATIONAHA.118.037216","article-title":"Glucose-sensitive myokine\/cardiokine MG53 regulates systemic insulin response\n                    and metabolic homeostasis","volume":"139","author":"H K Wu","year":"2019","journal-title":"Circulation"},{"issue":"02","key":"ref30","doi-asserted-by":"publisher","first-page":"e0245179","DOI":"10.1371\/journal.pone.0245179","article-title":"MG53 is not a critical regulator of insulin signaling pathway in\n                    skeletal muscle","volume":"16","author":"C Philouze","year":"2021","journal-title":"PLoS One"}],"container-title":["Experimental and Clinical Endocrinology &amp; Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2937-4910.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T22:54:33Z","timestamp":1788821673000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2937-4910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,20]]},"references-count":30,"URL":"https:\/\/doi.org\/10.1055\/a-2937-4910","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0947-7349","1439-3646"],"issn-type":[{"value":"0947-7349","type":"print"},{"value":"1439-3646","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,8,20]]},"published":{"date-parts":[[2026,8,20]]}}}