{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:08:32Z","timestamp":1790032112733,"version":"4.0.1"},"reference-count":13,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rofo"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Diffusion MRI is sensitive to tissue abnormalities in multiple sclerosis (MS), but conventional region-of-interest measures reduce spatially structured signal patterns to a single summary value. We evaluated boundary-anchored thalamic apparent diffusion coefficient (ADC) profiling in MS using line-based edge-anchored profiling (LEAP).<\/jats:p>\n                  <jats:p>In this retrospective matched-control study, age- and sex-matched controls (CTRL, n = 28) and participants with relapsing-remitting MS (RRMS, n = 14) or secondary progressive MS (SPMS, n = 14) were analyzed on the same 3T MRI scanner using the same diffusion protocol. LEAP was applied bilaterally at the medial thalamic surface adjacent to the third ventricle. Participant-averaged bilateral summary metrics and exploratory side-specific profile-shape metrics were derived from ADC curves.<\/jats:p>\n                  <jats:p>The clearest signal was observed in comparisons between MS and matched controls, with the largest number of differences seen for SPMS versus controls. Compared with controls, SPMS showed a higher ventricle-near mean ADC (p = 0.004), higher profile maximum ADC (p = 0.003), and a steeper early profile slope (p = 0.005). RRMS generally showed intermediate values. Direct RRMS-versus-SPMS comparisons of bilateral summary metrics were limited. Exploratory right-sided profile-shape metrics and left-right asymmetry measures suggested possible phenotype-related differences.<\/jats:p>\n                  <jats:p>Boundary-anchored thalamic ADC profiling detected spatially structured abnormalities in MS relative to matched controls, with the strongest deviation in SPMS. Exploratory shape-based findings should be considered hypothesis-generating and suggest additional profile-level information beyond bilateral summary values.<\/jats:p>","DOI":"10.1055\/a-2941-6690","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:45:33Z","timestamp":1790030733000},"source":"Crossref","is-referenced-by-count":0,"title":["Boundary-anchored thalamic ADC profiling shows spatially structured abnormalities in multiple sclerosis"],"prefix":"10.1055","author":[{"given":"Malvina","family":"Garner","sequence":"additional","affiliation":[{"name":"Saarland University Hospital, Germany","place":["Homburg"],"department":["Neuroradiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Fries","sequence":"additional","affiliation":[{"name":"Saarland University Hospital, Germany","place":["Homburg"],"department":["Neuroradiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Garner","sequence":"additional","affiliation":[{"name":"Saarland University Hospital, Germany","place":["Homburg"],"department":["Neuroradiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alena","family":"Hau\u00dfmann","sequence":"additional","affiliation":[{"name":"Saarland University Hospital, Germany","place":["Homburg"],"department":["Neuroradiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Reith","sequence":"additional","affiliation":[{"name":"Saarland University Hospital, Germany","place":["Homburg"],"department":["Neuroradiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4940-3575","authenticated-orcid":false,"given":"Umut","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Saarland University Hospital, Germany","place":["Homburg"],"department":["Neuroradiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1212\/WNL.0000000000000560","article-title":"Defining the clinical course of multiple sclerosis: the 2013 revisions","volume":"83","author":"FD Lublin","year":"2014","journal-title":"Neurology"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/S1474-4422(17)30470-2","article-title":"Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria","volume":"17","author":"AJ Thompson","year":"2018","journal-title":"Lancet Neurol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/S1474-4422(15)00393-2","article-title":"MRI criteria for the diagnosis of multiple sclerosis: MAGNIMS consensus guidelines","volume":"15","author":"M 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Biomed"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"58","DOI":"10.2463\/mrms.rev.2021-0091","article-title":"Advanced diffusion MR imaging for multiple sclerosis in the brain and spinal cord","volume":"21","author":"M Hori","year":"2022","journal-title":"Magn Reson Med Sci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/ana.25429","article-title":"A surface-in gradient of thalamic damage evolves in pediatric multiple sclerosis","volume":"85","author":"G Fadda","year":"2019","journal-title":"Ann Neurol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1093\/brain\/awaa379","article-title":"In vivo gradients of thalamic damage in paediatric multiple sclerosis: a window into pathology","volume":"144","author":"E De Meo","year":"2021","journal-title":"Brain"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1002\/ana.26448","article-title":"Ependymal-in gradient of thalamic damage in progressive multiple sclerosis","volume":"92","author":"R Magliozzi","year":"2022","journal-title":"Ann Neurol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2024.105834","article-title":"Increased periventricular thalamic damage gradient in multiple sclerosis detected by quantitative gradient echo MRI","volume":"90","author":"A Samara","year":"2024","journal-title":"Mult Scler Relat Disord"},{"key":"ref12","doi-asserted-by":"crossref","DOI":"10.3389\/fnhum.2022.944908","article-title":"Advanced diffusion MRI and image texture analysis detect widespread brain structural differences between relapsing-remitting and secondary progressive multiple sclerosis","volume":"16","author":"O Oladosu","year":"2022","journal-title":"Front Hum Neurosci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1097\/RCT.0b013e31825c6cee","article-title":"Differences in diffusion tensor imaging-derived metrics in the corpus callosum of patients with multiple sclerosis without and with gadolinium-enhancing cerebral lesions","volume":"36","author":"TJ Braley","year":"2012","journal-title":"J Comput Assist Tomogr"}],"container-title":["R\u00f6Fo - Fortschritte auf dem Gebiet der R\u00f6ntgenstrahlen und der bildgebenden 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