{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:52:34Z","timestamp":1792785154597,"version":"4.5.0"},"reference-count":37,"publisher":"Georg Thieme Verlag KG","issue":"10","funder":[{"name":"Van Yuzuncu Yil University","award":["TTU-2022-9941"],"award-info":[{"award-number":["TTU-2022-9941"]}],"id":[{"id":"https:\/\/ror.org\/041jyzp61","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Laparoscopic sleeve gastrectomy (LSG) is an effective surgical intervention for\nmorbid obesity, yet early hormonal changes contributing to metabolic adaptation\nremain underexplored. The objective of this study was to evaluate the early\npostoperative changes in the energy-regulating hormones irisin and nesfatin-1\nfollowing LSG in obese female patients. These hormones were selected due to\ntheir established roles in metabolic regulation and appetite control. This\npreliminary study included 27 women with obesity (body mass index, BMI&gt;40\nkg\/m\u00b2 or&gt;35 kg\/m\u00b2 with comorbidities) undergoing LSG. Serum irisin and\nnesfatin-1 levels, body composition, and standard metabolic parameters were\nassessed preoperatively and at 1 month postoperatively. ELISA assays were used\nfor hormone quantification. Repeated measures ANOVA and Spearman\u2019s correlation\nanalyses were applied. One month postoperatively, serum irisin levels showed a\nsignificant increase (p&lt;0.001), whereas nesfatin-1 levels demonstrated\na significant decrease (p&lt;0.001). Interestingly, nesfatin-1 exhibited\na significant positive correlation with fat mass in the preoperative period;\nhowever, this relationship shifted to a negative correlation following the\nsurgery, suggesting a potential alteration in regulatory mechanisms\npost-intervention. Reductions in BMI, fat mass, and muscle mass and improvements\nin glycemic and lipid profiles were also observed. The findings of this study\nreveal significant early postoperative shifts in irisin and nesfatin-1 levels\nfollowing LSG, underscoring the potential regulatory role of these hormones in\nthe body\u2019s initial metabolic adaptation to surgical weight loss.<\/jats:p>","DOI":"10.1055\/a-2941-6895","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T22:46:16Z","timestamp":1787957176000},"page":"406-412","source":"Crossref","is-referenced-by-count":0,"title":["Early Hormonal Responses of Irisin and Nesfatin-1 Following Sleeve Gastrectomy in Women with Obesity: A Preliminary Study"],"prefix":"10.1055","volume":"58","author":[{"given":"Ibrahim","family":"Ozalp","sequence":"additional","affiliation":[{"name":"Van Yuzuncu Yil Universitesi Tip Fakultesi, Van, Turkey","place":["Van"],"department":["General Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remzi","family":"Kiziltan","sequence":"additional","affiliation":[{"name":"Van Yuzuncu Yil Universitesi Tip Fakultesi, Van, Turkey","place":["Van"],"department":["General Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2489-3619","authenticated-orcid":false,"given":"Sermin","family":"Algul","sequence":"additional","affiliation":[{"name":"Van Yuzuncu Yil Universitesi Tip Fakultesi, Turkey","place":["Van"],"department":["Physiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oguz","family":"Ozcelik","sequence":"additional","affiliation":[{"name":"Kastamonu Universitesi Tip Fakultesi, Kastamonu, Turkey","place":["Kastamonu"],"department":["Physiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0011-393X(04)90025-2","article-title":"Effects of a weight-reduction program with orlistat on serum leptin levels 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in\nwomen with obesity","volume":"9","author":"O Ozcelik","year":"2015","journal-title":"Patient Prefer Adherence"},{"issue":"20","key":"ref5","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1001\/jama.2023.19897","article-title":"Obesity management in adults: A review","volume":"330","author":"A Elmaleh-Sachs","year":"2023","journal-title":"JAMA"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1016\/S0140-6736(22)02403-5","article-title":"Contemporary medical, device, and surgical therapies for obesity in adults","volume":"401","author":"C M Perdomo","year":"2023","journal-title":"Lancet"},{"issue":"08","key":"ref7","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1089\/lap.2018.0392","article-title":"Sleeve gastrectomy: Surgical tips","volume":"28","author":"A Y Chung","year":"2018","journal-title":"J Laparoendosc Adv Surg Tech 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bariatric surgery on circulating irisin levels","volume":"76","author":"T Jamialahamdi","year":"2024","journal-title":"Updates Surg"},{"issue":"7382","key":"ref12","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nature10777","article-title":"A PGC1-\u03b1-dependent myokine that drives brown-fat-like development of white fat\nand thermogenesis","volume":"481","author":"P Bostr\u00f6m","year":"2012","journal-title":"Nature"},{"issue":"06","key":"ref13","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/nrendo.2016.221","article-title":"Physiology and role of irisin in glucose homeostasis","volume":"13","author":"N Perakakis","year":"2017","journal-title":"Nat Rev Endocrinol"},{"issue":"05","key":"ref14","doi-asserted-by":"crossref","first-page":"3435","DOI":"10.1002\/smi.3435","article-title":"Evaluating the impact of metabolic and cognitive stress on ghrelin and\nnesfatin-1 hormones in patients with diabetes and diabetic depression","volume":"40","author":"S Alg\u00fcl","year":"2024","journal-title":"Stress Health"},{"issue":"7112","key":"ref15","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/nature05162","article-title":"Identification of nesfatin-1 as a satiety molecule in the hypothalamus","volume":"443","author":"S Oh-I","year":"2006","journal-title":"Nature"},{"issue":"06","key":"ref16","doi-asserted-by":"crossref","first-page":"979","DOI":"10.33549\/physiolres.933186","article-title":"Serum nesfatin-1 levels in patients with different glucose tolerance levels","volume":"65","author":"S Alg\u00fcl","year":"2016","journal-title":"Physiol Res"},{"issue":"10","key":"ref17","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1210\/js.2018-00246","article-title":"Current understanding of the role of nesfatin-1","volume":"2","author":"M A Schalla","year":"2018","journal-title":"J Endocr 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Tang","year":"2019","journal-title":"BMC Endocr Disord"},{"issue":"05","key":"ref22","first-page":"481","article-title":"Effect of sleeve gastrectomy on serum irisin","volume":"67","author":"M Demirpence","year":"2016","journal-title":"Endokrynol Pol"},{"issue":"04","key":"ref23","doi-asserted-by":"crossref","first-page":"660","DOI":"10.3390\/ijerph16040660","article-title":"Circulating irisin and weight loss after bariatric surgery","volume":"16","author":"Y J Lee","year":"2019","journal-title":"Int J Environ Res Public Health"},{"issue":"12","key":"ref24","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1016\/j.metabol.2012.09.002","article-title":"FNDC5 and irisin in humans","volume":"61","author":"J Y Huh","year":"2012","journal-title":"Metabolism"},{"issue":"04","key":"ref25","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1620\/tjem.206.313","article-title":"Exercise training reduces oxidative stress in obesity","volume":"206","author":"O Ozcelik","year":"2005","journal-title":"Tohoku J Exp Med"},{"issue":"01","key":"ref26","first-page":"45","article-title":"Irisin and oxidative stress in diabetes","volume":"38","author":"Y Khajebishak","year":"2023","journal-title":"J ASEAN Fed Endocr Soc"},{"issue":"01","key":"ref27","first-page":"5","article-title":"Aerobic exercise-induced oxidative stress and irisin\u2013nesfatin-1","volume":"1","author":"S U\u011fra\u015f","year":"2021","journal-title":"Kastamonu Med J"},{"issue":"01","key":"ref28","first-page":"38","article-title":"Improvement of inflammatory status after bariatric surgery","volume":"33","author":"M Recarte","year":"2023","journal-title":"Obes Surg"},{"issue":"05","key":"ref29","first-page":"881","article-title":"Serum irisin and insulin resistance","volume":"63","author":"B W Liu","year":"2017","journal-title":"Clin Lab"},{"issue":"10","key":"ref30","first-page":"1265","article-title":"Circulating irisin and lipid subparticles","volume":"63","author":"G Panagiotou","year":"2014","journal-title":"Metabolism"},{"key":"ref31","first-page":"21","article-title":"Nesfatin-1 in childhood obesity","volume":"188","author":"G M Anwar","year":"2014","journal-title":"Regul Pept"},{"issue":"04","key":"ref32","first-page":"484","article-title":"Nesfatin-1 and body fat","volume":"73","author":"T Tsuchiya","year":"2010","journal-title":"Clin Endocrinol"},{"key":"ref33","first-page":"828571","article-title":"Hypothalamic nesfatin-1 resistance","volume":"16","author":"M Durst","year":"2022","journal-title":"Front Neurosci"},{"issue":"03","key":"ref34","first-page":"1616","article-title":"Curcumin and nesfatin-1 in diabetic rats","volume":"25","author":"S Alg\u00fcl","year":"2021","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"32","key":"ref35","first-page":"5830","article-title":"Nesfatin-1 changes after bariatric surgery","volume":"19","author":"W J Lee","year":"2013","journal-title":"Curr Pharm Des"},{"issue":"06","key":"ref36","first-page":"1023","article-title":"Nesfatin-1 after sleeve gastrectomy","volume":"20","author":"U Dogan","year":"2016","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.jad.2023.04.113","article-title":"Weight change and mental health","volume":"334","author":"C L Goessl","year":"2023","journal-title":"J Affect Disord"}],"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2941-6895.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:37:17Z","timestamp":1792622237000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2941-6895"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,28]]},"references-count":37,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,10,21]]},"published-print":{"date-parts":[[2026,10]]}},"URL":"https:\/\/doi.org\/10.1055\/a-2941-6895","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,28]]}}}