{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:56:23Z","timestamp":1790898983851,"version":"4.1.0"},"reference-count":52,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"abstract":"Abstract<\/jats:title>\n Background Polycystic ovary syndrome is a complex endocrine-metabolic\n disorder associated with various dermatological manifestations. However, the\n histomorphological alterations underlying these skin findings remain poorly\n characterized. This study aimed to investigate skin alterations associated with\n polycystic ovary syndrome in an experimental mouse model using histochemical\n staining, morphometric evaluation, and immunofluorescence analysis.<\/jats:p>\n Methods An experimental study was performed using 16 Swiss albino female\n mice. The polycystic ovary syndrome model was induced by dehydroepiandrosterone\n (6 mg\/100 g body weight; subcutaneous). Model validation was performed using\n ovarian histology, estrous cycle monitoring, body weight, fasting blood glucose,\n and the intraperitoneal glucose tolerance test. Skin tissues were evaluated\n using haematoxylin and eosin staining for epidermal and dermal thicknesses,\n Masson\u2019s trichrome staining for collagen content (quantified with ImageJ), and\n immunofluorescence staining for Ki-67 and vascular endothelial growth factor\n immunoreactivity.<\/jats:p>\n Results The polycystic ovary syndrome model was successfully validated\n using histological, reproductive, and metabolic parameters. The epidermal\n thickness was significantly reduced in the polycystic ovary syndrome group\n compared with the control group, and the dermal collagen content was also\n decreased. Ki-67 immunoreactivity appeared reduced in the polycystic ovary\n syndrome group, suggesting decreased cellular proliferative activity. Vascular\n endothelial growth factor immunoreactivity showed a similar staining pattern in\n both groups.<\/jats:p>\n Conclusions Dehydroepiandrosterone-induced polycystic ovary syndrome\n resulted in significant histological alterations in the skin, including\n epidermal thinning, reduced proliferative activity, and decreased dermal\n collagen content. These findings suggest that PCOS-associated skin alterations\n may be linked to impaired epidermal renewal and disrupted extracellular matrix\n organization, supporting the concept that polycystic ovary syndrome exerts\n systemic effects beyond the reproductive organs.<\/jats:p>","DOI":"10.1055\/a-2942-6488","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T22:37:39Z","timestamp":1788561459000},"source":"Crossref","is-referenced-by-count":0,"title":["Impaired Epidermal Renewal and Dermal Collagen Disorganization in a\n Dehydroepiandrosterone-Induced Mouse Model of Polycystic Ovary\n Syndrome"],"prefix":"10.1055","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1764-6807","authenticated-orcid":false,"given":"\u00d6zlem","family":"Deliba\u015f","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Sivas, Turkey","place":["Sivas Cumhuriyet University"],"department":["Department of Histology and Embryology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berna \u00d6zdeno\u011flu","family":"Kutlu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Sivas, Turkey","place":["Sivas Cumhuriyet University"],"department":["Department of Histology and Embryology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serpil \u00dcnver","family":"Sarayd\u0131n","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Sivas, Turkey","place":["Sivas Cumhuriyet University"],"department":["Department of Histology and Embryology"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,9,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1097\/MS9.0000000000003217","article-title":"A narrative review on cutaneous manifestations in polycystic ovary syndrome:\n Pathophysiology, diagnosis, management, and psychosocial 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Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2942-6488.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:49:47Z","timestamp":1790898587000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2942-6488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,4]]},"references-count":52,"URL":"https:\/\/doi.org\/10.1055\/a-2942-6488","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0947-7349","1439-3646"],"issn-type":[{"value":"0947-7349","type":"print"},{"value":"1439-3646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,4]]}}}