{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:09:26Z","timestamp":1790032166534,"version":"4.0.1"},"reference-count":29,"publisher":"Georg Thieme Verlag KG","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ultraschall Med"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>To evaluate the diagnostic accuracy of Canon Aplio i800 two-dimensional shear wave elastography (2D-SWE) for detecting advanced fibrosis (\u2265 F3) in metabolically associated steatotic liver disease (MASLD) using histology as reference, and to compare its performance with the FIB-4 index.<\/jats:p>\n                  <jats:p>In this prospective single-center study, 49 patients with MASLD and available liver histology were included. Fibrosis staging (F0\u2013F4) was assessed by three blinded pathologists according to Brown and Kleiner. Shear wave velocity (m\/s) served as the primary elastography parameter. Diagnostic performance for \u2265 F3 was assessed by ROC analysis, and clinically applicable rule-in and rule-out thresholds were determined using predefined sensitivity- and specificity-based criteria.<\/jats:p>\n                  <jats:p>Advanced fibrosis (\u2265 F3) was present in 15\/49 patients (30.6%). 2D-SWE demonstrated an AUROC of 0.88 (95% CI 0.78\u20130.96) for \u2265 F3, compared with 0.84 (95% CI 0.71\u20130.96) for FIB-4 (p = 0.39). A threshold of 1.45 m\/s (6.3 kPa) achieved 100% sensitivity and negative predictive value. A threshold of 1.85 m\/s (11.0 kPa) yielded 94% specificity and 82% positive predictive value.<\/jats:p>\n                  <jats:p>Canon Aplio i800 2D-SWE provides robust and clinically applicable, device-specific non-invasive detection of advanced fibrosis in MASLD and supports implementation into guideline-based stepwise risk stratification.<\/jats:p>","DOI":"10.1055\/a-2942-6555","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:48:57Z","timestamp":1790030937000},"source":"Crossref","is-referenced-by-count":0,"title":["Device-Specific Cut-Offs of Canon Aplio i800 2D Shear Wave Elastography for Advanced Fibrosis in MASLD: A Histologically Validated Study"],"prefix":"10.1055","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9727-3843","authenticated-orcid":false,"given":"Wolfgang","family":"Kratzer","sequence":"first","affiliation":[{"name":"University Hospital Ulm, Germany","place":["Ulm"],"department":["Department of Internal Medicine I"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Binzberger","sequence":"first","affiliation":[{"name":"University Hospital Ulm, Germany","place":["Ulm"],"department":["Department of Internal Medicine I"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan G.","family":"Kauschke","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim Pharma GmbH & Co. KG, Germany","place":["Biberach"],"department":["Department of Cardiometabolic Research"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finn","family":"Dolze","sequence":"additional","affiliation":[{"name":"University Hospital Ulm, Germany","place":["Ulm"],"department":["Department of Internal Medicine I"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Werner","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim Pharma GmbH & Co. KG, Germany","place":["Biberach"],"department":["Department of Cardiometabolic Research"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F.E.","family":"Barth","sequence":"additional","affiliation":[{"name":"University Hospital Ulm, Germany","place":["Ulm"],"department":["Department of Pathology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeleine","family":"Feller","sequence":"additional","affiliation":[{"name":"University Hospital Ulm, Germany","place":["Ulm"],"department":["Department of Internal Medicine I"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Neubauer","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim Pharma GmbH & Co. KG, Germany","place":["Biberach"],"department":["Global Cardio-metabolic Diseases"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Simon","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim Pharma GmbH & Co. KG, Germany","place":["Biberach"],"department":["Department of Global Computational Biology and Digital Sciences"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas-David","family":"Brunner","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim Pharma GmbH & Co. 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