{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T23:17:26Z","timestamp":1788391046878,"version":"build-2803163510"},"reference-count":7,"publisher":"Georg Thieme Verlag KG","funder":[{"name":"Riley Children's Foundation through the Neonatology Division Pilot Project Grant Award"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The purpose of this study was to identify postnatal factors that may confer an increased risk for having a delayed thyroid-stimulating hormone (TSH) rise on the newborn screen (NBS) in infants admitted to the neonatal intensive care unit (NICU).<\/jats:p>\n                  <jats:p>NBS results were collected from the Indiana State Department of Health (ISDH) for all cases of congenital hypothyroidism (CH) from 2012 to 2022 and used to identify infants who had a delayed TSH rise (N\u2009=\u200973). Thirty-six infants with a delayed diagnosis were matched by gestational age and birth weight Z-scores to infants with CH who were diagnosed in a timely manner per their initial NBS. A retrospective chart review was performed to compare postnatal factors between these two groups and to determine the treatment outcome in infants with a delayed versus timely diagnosis of CH.<\/jats:p>\n                  <jats:p>Infants with a delayed TSH rise had significantly higher odds of medication exposures, invasive surgical procedures, and complications related to the renal, gastrointestinal, and hematologic systems. Delayed infants had 3.02 times the number of bedside procedures that involved iodine-containing sterile preparation (95% confidence interval [CI]: 1.31\u20136.93, p\u2009=\u20090.009) compared with the timely cohort. Within the delayed cohort, 38% of infants were found to have transient CH as compared with 27% of infants in the timely cohort.<\/jats:p>\n                  <jats:p>Several postnatal factors appear to play a role in conferring a risk for a delayed TSH rise, implying that the etiology of this phenomenon is multifactorial. Our findings suggest the need for more targeted screening for CH within the NICU.<\/jats:p>","DOI":"10.1055\/a-2943-5102","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T22:43:18Z","timestamp":1788388998000},"source":"Crossref","is-referenced-by-count":0,"title":["A Comparison of Postnatal Factors between Infants with a Delayed TSH Rise on the Newborn Screen and those with a Timely Diagnosis of Congenital Hypothyroidism"],"prefix":"10.1055","author":[{"given":"Louis J.","family":"Martin","sequence":"first","affiliation":[{"name":"Indiana University School of Medicine, Indiana, United States","place":["Indianapolis"],"department":["Department of Perinatal-Neonatal Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica A.","family":"Eugster","sequence":"first","affiliation":[{"name":"Indiana University School of Medicine, Indiana, United States","place":["Indianapolis"],"department":["Department of Pediatrics"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9451-965X","authenticated-orcid":false,"given":"Preet K.","family":"Matharu","sequence":"additional","affiliation":[{"name":"University of California Davis Health, California, United States","place":["Sacramento"],"department":["Department of Pediatrics"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1007\/s10545-011-9286-8","article-title":"Newborn screening for congenital hypothyroidism in very-low-birth-weight babies: the need for a second test","volume":"34","author":"S Bijarnia","year":"2011","journal-title":"J Inherit Metab Dis"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1159\/000543744","article-title":"Clinical and demographic factors associated with a delayed TSH rise in infants with congenital hypothyroidism: a retrospective review of a 10-year cohort in Indiana","volume":"99","author":"P K Matharu","year":"2026","journal-title":"Horm Res Paediatr"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"113974","DOI":"10.1016\/j.jpeds.2024.113974","article-title":"Screening for delayed thyroid stimulation hormone rise and atypical congenital hypothyroidism in infants born very preterm and infants with very low birth weight","volume":"269","author":"B Nolan","year":"2024","journal-title":"J Pediatr"},{"issue":"08","key":"ref4","doi-asserted-by":"crossref","first-page":"3050","DOI":"10.1210\/jc.2017-00701","article-title":"Risk factors for the development of delayed TSH elevation in neonatal intensive care unit newborns","volume":"102","author":"A Zung","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"issue":"03","key":"ref5","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/S0022-3476(97)80071-6","article-title":"Topical iodine-containing antiseptics and subclinical hypothyroidism in preterm infants","volume":"131","author":"N Linder","year":"1997","journal-title":"J Pediatr"},{"issue":"01","key":"ref6","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/apa.70312","article-title":"Permanent or transient congenital hypothyroidism: a diagnostic dilemma","volume":"115","author":"N Dermitzaki","year":"2026","journal-title":"Acta Paediatr"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jpeds.2018.09.044","article-title":"Optimal timing of repeat newborn screening for congenital hypothyroidism in preterm infants to detect delayed thyroid-stimulating hormone elevation","volume":"205","author":"N McGrath","year":"2019","journal-title":"J Pediatr"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2943-5102.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T22:43:27Z","timestamp":1788389007000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2943-5102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,2]]},"references-count":7,"URL":"https:\/\/doi.org\/10.1055\/a-2943-5102","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,2]]}}}