{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T01:01:29Z","timestamp":1790038889999,"version":"4.0.1"},"reference-count":15,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"abstract":"Zusammenfassung<\/jats:title>\n Hintergrund Filtrierende Operationen sind seit Jahrzehnten der Goldstandard in der Glaukomchirurgie, doch fibrotische Prozesse bleiben eine Hauptursache f\u00fcr das Therapieversagen. Moderne glaukomchirurgische Verfahren bieten eine weniger invasive Alternative, sind jedoch oft weniger wirksam bei der Drucksenkung. Der Preserflo MicroShunt kombiniert die Prinzipien der traditionellen filtrierenden Chirurgie mit mikroinvasiven Techniken, um eine effektive Senkung des intraokularen Drucks (IOD) zu erreichen.<\/jats:p>\n Patienten und Methoden In dieser retrospektiven monozentrischen Studie wurden die klinischen Daten von 74 Patienten analysiert, die in den Jahren 2021 und 2022 an einer Universit\u00e4ts-Augenklinik mit dem Preserflo MicroShunt operativ behandelt wurden. Das Durchschnittsalter betrug 71,1 \u00b1 10,3 Jahre. Die h\u00e4ufigsten Glaukomtypen waren prim\u00e4res Offenwinkelglaukom (52,7%), Pseudoexfoliationsglaukom (22,9%), Normaldruckglaukom (9,4%) und Engwinkelglaukom (4%). Die Nachbeobachtungszeit betrug median 326 Tage. Ausgewertet wurde der Therapieerfolg anhand des Augeninnendrucks, der Revisionsrate und der Notwendigkeit erneuter drucksenkender Eingriffe mittels deskriptiver Statistik und Kaplan-Meier-Analyse.<\/jats:p>\n Ergebnisse Nach einer medianen Nachbeobachtungszeit von 326 Tagen erreichten 38,0% der Augen den absoluten Therapieerfolg (IOD \u2264 18 mmHg und \u226520% Reduktion gegen\u00fcber dem Ausgangswert ohne medikament\u00f6se Therapie), w\u00e4hrend 39,9% den relativen Erfolg erreichten (IOD \u2264 18 mmHg und \u226520% Reduktion, inklusive medikament\u00f6ser Therapie). In 78,7% der F\u00e4lle war kein weiterer drucksenkender Eingriff erforderlich, und bei 63,8% der Patienten blieb eine Revision des Preserflo-Implantats aus.<\/jats:p>\n Schlussfolgerung Diese monozentrische Studie pr\u00e4sentiert aktuelle, einheitliche Daten aus unserer Klinik zur Wirksamkeit des Preserflo MicroShunts bei Glaukompatienten und erg\u00e4nzt somit die vorhandene Evidenz zu vergleichbaren filtrierenden Verfahren. Die beobachteten Erfolgsraten liegen etwas niedriger im Vergleich zu anderen Verfahren, m\u00f6glicherweise bedingt durch das universit\u00e4re Setting, komplexe Vorbehandlungen der Patienten sowie das retrospektive Studiendesign mit uneinheitlichen Nachbeobachtungsintervallen und abnehmender Risikopopulation im Langzeitverlauf. L\u00e4ngere prospektive Studien sind erforderlich, um die Langzeiteffektivit\u00e4t und das Sicherheitsprofil weiter zu evaluieren.<\/jats:p>","DOI":"10.1055\/a-2944-0690","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T22:48:01Z","timestamp":1789512481000},"source":"Crossref","is-referenced-by-count":0,"title":["Therapeutic Success and Revision Rate after Preserflo MicroShunt Implantation: A Monocentric Analysis of 74 Cases"],"prefix":"10.1055","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0547-346X","authenticated-orcid":false,"given":"Gloria","family":"Helmers","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Freiburg, Baden-W\u00fcrttemberg, Germany","place":["Freiburg"],"department":["Klinik f\u00fcr Augenheilkunde"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"B\u00f6hringer","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Freiburg, Baden-W\u00fcrttemberg, Germany","place":["Freiburg"],"department":["Klinik f\u00fcr Augenheilkunde"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8307-5267","authenticated-orcid":false,"given":"Philip","family":"Keye","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Freiburg, Baden-W\u00fcrttemberg, Germany","place":["Freiburg"],"department":["Klinik f\u00fcr Augenheilkunde"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Thelen","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Freiburg, Baden-W\u00fcrttemberg, Germany","place":["Freiburg"],"department":["Klinik f\u00fcr Augenheilkunde"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Reinhard","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Freiburg, Baden-W\u00fcrttemberg, Germany","place":["Freiburg"],"department":["Klinik f\u00fcr Augenheilkunde"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3946-5759","authenticated-orcid":false,"given":"Jan","family":"Luebke","sequence":"additional","affiliation":[{"name":"Universitatsklinikum Freiburg, Germany","place":["Freiburg"],"department":["Klinik f\u00fcr Augenheilkunde"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"issue":"04","key":"ref1","doi-asserted-by":"publisher","first-page":"2904","DOI":"10.3390\/ijerph20042904","article-title":"The PreserFlo MicroShunt in the Context of Minimally Invasive Glaucoma Surgery: A Narrative Review","volume":"20","author":"E Saeed","year":"2023","journal-title":"IJERPH"},{"key":"ref2","volume-title":"Guidelines on Design and Reporting of Glaucoma Surgical Trials","author":"World Glaucoma 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