{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:10:35Z","timestamp":1789189835191,"version":"build-2803163510"},"reference-count":22,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"abstract":"<jats:p>Platelet activation and thrombopoiesis are central to acute cardiovascular disease pathophysiology, yet the prognostic role of the immature platelet fraction (IPF) remains incompletely defined in heterogeneous intensive cardiovascular care unit (ICCU) populations.<\/jats:p>\n                  <jats:p>We conducted a single-center, observational study of 6,725 consecutive ICCU admissions with IPF measured. The primary endpoint was in-hospital all-cause mortality using multivariable logistic regression, and discrimination by receiver operating characteristic analysis.<\/jats:p>\n                  <jats:p>Median age was 70 years; 31.8% were women. Increasing IPF quartiles showed a stepwise rise in mortality (2.1 to 3.7%; p-trend\u2009=\u20090.003), acute renal failure (ARF) (2.4 to 5.1%; p\u2009&lt;\u20090.001), malignant arrhythmia (0.9 to 2.2%; p\u2009=\u20090.002), and in-hospital cardiogenic shock (2.7 to 4.7%; p\u2009=\u20090.008); the regression analysis for cardiogenic shock was restricted to incident cases among non-shock admissions (n\u2009=\u20095,778). After multivariable adjustment, each 1 natural-log-unit increment in IPF (\u223c1.7\u00d7 raw IPF) remained independently associated with mortality (OR 1.55, 95% CI: 1.10\u20132.19), ARF (OR 1.75, 1.37\u20132.25), malignant arrhythmia (OR 2.07, 1.44\u20132.98), and cardiogenic shock (OR 1.51, 1.16\u20131.96). Discrimination of IPF alone was modest (AUC 0.57\u20130.59), but incorporation into multivariable models improved performance (mortality AUC 0.78). Reclassification analysis demonstrated incremental value beyond baseline (categorical net reclassification improvement [NRI] +6.9 to +12.1%; continuous NRI 0.14\u20130.28).<\/jats:p>\n                  <jats:p>In this large, contemporary ICCU cohort, elevated IPF was independently associated with in-hospital mortality, as well as adverse outcomes. Although not a standalone discriminator, IPF is a readily available, low-cost biomarker that may enhance early mortality risk stratification when integrated with established clinical variables, supporting further evaluation in multimodal and machine learning\u2013based prediction frameworks.<\/jats:p>","DOI":"10.1055\/a-2944-1196","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:04:41Z","timestamp":1789189481000},"source":"Crossref","is-referenced-by-count":0,"title":["Immature Platelet Fraction as an Independent Marker of Adverse Outcomes in an Intensive Cardiovascular Care Unit"],"prefix":"10.1055","author":[{"given":"Elad","family":"Asher","sequence":"additional","affiliation":[{"name":"Jesselson Integrated Heart Center, Shaare Zedek Medical Center, The Eisenberg R&D Authority, and Faculty of Medicine, Hebrew University of Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louay","family":"Taha","sequence":"additional","affiliation":[{"name":"Jesselson Integrated Heart Center, Shaare Zedek Medical Center, The Eisenberg R&D Authority, and Faculty of Medicine, Hebrew University of Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Karmi","sequence":"additional","affiliation":[{"name":"Jesselson Integrated Heart Center, Shaare Zedek Medical Center, The Eisenberg R&D Authority, and Faculty of Medicine, Hebrew University of Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiva","family":"Brin","sequence":"additional","affiliation":[{"name":"Shaare Zedek Medical Center, Israel","place":["Jerusalem"],"department":["Department of Cardiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Sabouret","sequence":"additional","affiliation":[{"name":"ACTION Study Group, Institut de Cardiologie, Sorbonne Universit\u00e9, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, \u00cele-de-France, France","place":["Paris"],"department":["Cardiology Department"]},{"name":"French National College of Cardiologists, Ile-de-France, France","place":["Paris"],"department":["Department of Cardiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamas A.","family":"Mamas","sequence":"additional","affiliation":[{"name":"Centre for Prognosis Research, Keele University, Staffordshire, United Kingdom of Great Britain and Northern Ireland","place":["Keele"],"department":["Keele Cardiovascular Research Group"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noam","family":"Fink","sequence":"additional","affiliation":[{"name":"Assuta Medical Centers, Faculty of Medicine, Hebrew University of Jerusalem, Tel Aviv District, Israel","place":["Tel Aviv-Yafo"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ari","family":"Naimark","sequence":"additional","affiliation":[{"name":"Jesselson Integrated Heart Center, Shaare Zedek Medical Center, The Eisenberg R&D Authority, and Faculty of Medicine, Hebrew University of Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amjad","family":"Abu-Salman","sequence":"additional","affiliation":[{"name":"Jesselson Integrated Heart Center, Shaare Zedek Medical Center, The Eisenberg R&D Authority, and Faculty of Medicine, Hebrew University of Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Glikson","sequence":"additional","affiliation":[{"name":"Jesselson Integrated Heart Center, Shaare Zedek Medical Center, The Eisenberg R&D Authority, and Faculty of Medicine, Hebrew University of Jerusalem, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"issue":"12","key":"ref1","doi-asserted-by":"crossref","first-page":"3378","DOI":"10.1172\/JCI27196","article-title":"Platelets in inflammation and atherogenesis","volume":"115","author":"M Gawaz","year":"2005","journal-title":"J Clin Invest"},{"issue":"03","key":"ref2","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1751-553X.2009.01160.x","article-title":"Quality counts: new parameters in blood cell counting","volume":"31","author":"C Briggs","year":"2009","journal-title":"Int J Lab Hematol"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1538-7836.2010.04110.x","article-title":"High platelet volume and increased risk of myocardial infarction: 39,531 participants from the general population","volume":"9","author":"J Klovaite","year":"2011","journal-title":"J Thromb 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