{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:08:20Z","timestamp":1789189700833,"version":"build-2803163510"},"reference-count":39,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Facial Plast Surg"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Botulinum toxin type A is widely used for facial rejuvenation, but prospective real-world data integrating safety and patient-reported outcomes (PROs) remain limited.<\/jats:p>\n                  <jats:p>To evaluate complication rates, patient satisfaction, and predictors of satisfaction following standardized upper-face injections.<\/jats:p>\n                  <jats:p>Prospective, single-center cohort study.<\/jats:p>\n                  <jats:p>A total of 489 patients undergoing 2,012 procedures were treated using a standardized protocol. Clinically significant complications were recorded over 4 weeks. PROs were assessed using a customized 20-item questionnaire.<\/jats:p>\n                  <jats:p>The per-patient complication rate was 13.1%, while the per-procedure rate was 3.3%. Most complications were mild and resolved without sequelae. Overall, 94.1% of patients reported improvement, and 79.6% achieved \u2265\u20099\/10 satisfaction. Younger age, female sex, and lower complication severity were associated with higher satisfaction.<\/jats:p>\n                  <jats:p>Standardized botulinum toxin protocols provide low complication rates and high patient satisfaction. Combined reporting of safety and PROs supports reproducible and clinically relevant evaluation.<\/jats:p>","DOI":"10.1055\/a-2945-2316","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:03:42Z","timestamp":1789189422000},"source":"Crossref","is-referenced-by-count":0,"title":["Botox Complications and Satisfaction Outcomes Following Botulinum Toxin Type A Facial Injections: A Prospective Study of 2,012 Procedures in 489 Patients"],"prefix":"10.1055","author":[{"given":"Raul Daniel","family":"Chioiba\u0219","sequence":"additional","affiliation":[{"name":"Emergency Discipline, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Romania","place":["Timisoara"],"department":["Department of Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3379-817X","authenticated-orcid":false,"given":"Dan","family":"Lolos","sequence":"additional","affiliation":[{"name":"University of Medicine and Pharmacy Timi\u0219oara, Romania","place":["Timisoara"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreea Raissa","family":"Hojda","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy Timi\u0219oara, Romania","place":["Timisoara"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan Antonio","family":"Lolos","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cVasile Goldis\u201d Western University of Arad, Romania","place":["Arad"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Sykes","sequence":"additional","affiliation":[{"name":"University of California Davis School of Medicine, California, United States","place":["Sacramento"],"department":["Department of Otolaryngology\u2013Head and Neck Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"issue":"20","key":"ref1","doi-asserted-by":"crossref","first-page":"4217","DOI":"10.1007\/s00266-024-04260-2","article-title":"Trends in surgical and nonsurgical aesthetic procedures: A 14-year analysis of the International Society of Aesthetic Plastic Surgery-ISAPS","volume":"48","author":"L Triana","year":"2024","journal-title":"Aesthetic Plast Surg"},{"issue":"05","key":"ref2","doi-asserted-by":"crossref","first-page":"NP327","DOI":"10.1093\/asj\/sjac036","article-title":"Complications of cosmetic botulinum toxin A injections to the upper face: a systematic review and meta-analysis","volume":"42","author":"D Zargaran","year":"2022","journal-title":"Aesthet Surg J"},{"issue":"07","key":"ref4","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1111\/jocd.16289","article-title":"Evaluation of people's satisfaction with botulinum toxin 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Surg"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"413","DOI":"10.2147\/CCID.S138274","article-title":"Tailored botulinum toxin type A injections in aesthetic medicine: consensus panel recommendations for treating the forehead based on individual facial anatomy and muscle tone","volume":"10","author":"J Anido","year":"2017","journal-title":"Clin Cosmet Investig Dermatol"},{"issue":"01","key":"ref39","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1097\/DSS.0000000000003985","article-title":"Applicability of patient-reported outcome measures to aesthetic medicine patient archetypes","volume":"50","author":"S Rauch","year":"2024","journal-title":"Dermatol Surg"},{"issue":"04","key":"ref40","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1055\/s-0030-1262313","article-title":"Measuring patient-reported outcomes in facial aesthetic patients: development of the FACE-Q","volume":"26","author":"A F Klassen","year":"2010","journal-title":"Facial Plast 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