{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T23:08:28Z","timestamp":1788736108625,"version":"build-2803163510"},"reference-count":25,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thorac Cardiovasc Surg"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background\u2003Studies reported a strong relationship between cystatin C and postsurgical acute kidney injury (AKI) following cardiac surgery. This study aims to establish the above relationship in acute type A aortic dissection (ATAAD) patients.<\/jats:p>\n                  <jats:p>Methods\u2003ATAAD patients receiving hemiarch replacement in combination with modified triple-branched stent-graft (MTBSG) implantation were recruited. The relationship between cystatin C and AKI, as well as in-hospital mortality, was analyzed.<\/jats:p>\n                  <jats:p>Results\u2003About 459 patients were enrolled. A total of 223 (48.6%) exhibited AKI and 71 (15.5%) exhibited severe AKI. AKI patients displayed elevated perioperative cystatin C levels. Upon adjustment of known AKI hazards, the logarithmically transformed presurgical cystatin C (odds ratio\u2009=\u20091.66 [95% confidence interval, 1.20\u20132.30], p\u2009=\u20090.010), postsurgical day 1 cystatin C (odds ratio\u2009=\u20092.61 [95% confidence interval, 1.70\u20134.13], p\u2009=\u20090.002), postsurgical day 2 cystatin C (odds ratio\u2009=\u20093.01 [95% confidence interval, 2.22\u20134.07], p\u2009=\u20090.001), and postsurgical day 3 cystatin C (odds ratio\u2009=\u20092.89 [95% confidence interval, 1.99\u20133.86], p\u2009=\u20090.009) were intricately linked to severe AKI. Moreover, these relationships remained even after adjusting for filtration reduction via alterations in serum creatinine (\u0394creatinine) and urea nitrogen (\u0394urea nitrogen). Relative to the clinical model, cystatin C enhanced the risk discrimination and restratification of AKI.<\/jats:p>\n                  <jats:p>Conclusion\u2003For ATAAD patients, cystatin C greatly enhanced postsurgical AKI risk stratification. When dynamic cystatin C levels indicate a high risk of severe AKI, more aggressive monitoring should be performed to assess whether more intensive stent intervention is warranted to improve renal artery perfusion.<\/jats:p>","DOI":"10.1055\/a-2945-9260","type":"journal-article","created":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T22:30:26Z","timestamp":1788733826000},"source":"Crossref","is-referenced-by-count":0,"title":["Serum Cystatin C Predicts Postsurgical Acute Kidney Injury in Aortic Dissection"],"prefix":"10.1055","author":[{"given":"Qu-Bo","family":"Huang","sequence":"first","affiliation":[{"name":"Fujian Medical University Union Hospital, Fujian, People's Republic of China","place":["Fuzhou"],"department":["Department of Cardiology Nursing"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Xin","family":"Zhang","sequence":"first","affiliation":[{"name":"Fujian Medical University Union Hospital, Fujian, People's Republic of China","place":["Fuzhou"],"department":["Department of Cardiovascular Surgery"]},{"name":"Key Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), Fujian Province University, Fujian, People's Republic of China","place":["Fuzhou"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Wen","family":"Wang","sequence":"additional","affiliation":[{"name":"Fujian Medical University Union Hospital, Fujian, People's Republic of China","place":["Fuzhou"],"department":["Department of Cardiovascular Surgery"]},{"name":"Key Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), Fujian Province University, Fujian, People's Republic of China","place":["Fuzhou"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8143-0368","authenticated-orcid":false,"given":"Zeng-Rong","family":"Luo","sequence":"additional","affiliation":[{"name":"Fujian Medical University Union Hospital, Fujian, People's Republic of China","place":["Fuzhou"],"department":["Department of Cardiovascular Surgery"]},{"name":"Key Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), Fujian Province University, Fujian, People's Republic of China","place":["Fuzhou"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,9,6]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1093\/icvts\/ivaa164","article-title":"Acute kidney injury in patients operated on for type A acute aortic dissection: incidence, risk factors and short-term outcomes","volume":"31","author":"Z Wang","year":"2020","journal-title":"Interact Cardiovasc Thorac Surg"},{"issue":"03","key":"ref2","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.athoracsur.2019.12.027","article-title":"Efficiency of modified triple-branched stent graft in type I aortic dissection: two-year follow-up","volume":"110","author":"Z H 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