{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T23:06:22Z","timestamp":1789427182342,"version":"build-2803163510"},"reference-count":49,"publisher":"Georg Thieme Verlag KG","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Cancer Institute","award":["1R01CA300566"],"award-info":[{"award-number":["1R01CA300566"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Synthesis"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Streptomyces clavuligerus biosynthesizes a nine-membered ring enediyne that spontaneously cycloaromatizes to a 1,4-benzenoid diradical enroute to the clavulynes. Since nature also produces several isolable and exceedingly cytotoxic metabolites featuring 10-membered ring enediynes, we reasoned that a ring-expanded \u201chomo-clavulyne\u201d enediyne might be accessible by the concepts and methods of organic synthesis, isolable, and useful as a new molecular warhead with therapeutic applications. The design of a 10-membered ring homo-clavulyne enediyne and our circumstantial evidence for its existence are described herein.<\/jats:p>","DOI":"10.1055\/a-2951-5568","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:49:27Z","timestamp":1789426167000},"source":"Crossref","is-referenced-by-count":0,"title":["Homo-Clavulyne: Evaluation of a One-Atom Ring Expansion Strategy to Stabilize the Nine-Membered Ring Enediyne Biosynthetic Precursor"],"prefix":"10.1055","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0359-6424","authenticated-orcid":false,"given":"Lande","family":"Hu","sequence":"additional","affiliation":[{"name":"Princeton University, New Jersey, United States","place":["Princeton"],"department":["Department of Chemistry"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myungeun","family":"Jeong","sequence":"additional","affiliation":[{"name":"Princeton University, New Jersey, United States","place":["Princeton"],"department":["Department of Chemistry"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad R.","family":"Seyedsayamdost","sequence":"additional","affiliation":[{"name":"Princeton University, New Jersey, United States","place":["Princeton"],"department":["Department of Chemistry"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik J.","family":"Sorensen","sequence":"additional","affiliation":[{"name":"Princeton University, New Jersey, United States","place":["Princeton"],"department":["Department of Chemistry"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,9,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1021\/ja00757a071","volume":"94","author":"R R Jones","year":"1972","journal-title":"J Am Chem 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