{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T23:07:27Z","timestamp":1789427247803,"version":"build-2803163510"},"reference-count":10,"publisher":"Georg Thieme Verlag KG","issue":"CP","license":[{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Cancer Center Research and Development Fund","award":["2023-A-09"],"award-info":[{"award-number":["2023-A-09"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Although post-endoscopic submucosal dissection (ESD) mucosal defects can lead to delayed bleeding and perforation, an optimal protective method has not yet been established. This study aimed to evaluate the feasibility of using artificial dermis to protect against gastrointestinal mucosal defects. ex vivo and in vivo porcine models were used. Artificial dermis sheets (collagen monolayer or collagen\u2013silicone bilayer) were applied to 2-cm post-ESD ulcers in the stomach, rectum, and esophagus and fixed using standard endoscopic clips. Fixation success, coverage durability, adverse events, and histopathologic findings were evaluated. In the ex vivo experiments, artificial dermis was successfully fixed with clips, both manually and endoscopically, without material damage (4\/4 sites per experiment). In the in vivo experiments, fixation was successful at all planned gastric and esophageal sites (5\/5, 100%). The bilayer sheets appeared to remain in place more consistently at day 3 in the stomach. No serious adverse events were observed. Endoscopic application of artificial dermis was technically feasible for temporary coverage of gastrointestinal mucosal defects in porcine models, with collagen\u2013silicone bilayer sheets showing more consistent retention during the initial observation period. However, further clinical studies are warranted.<\/jats:p>","DOI":"10.1055\/a-2953-8822","type":"journal-article","created":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T22:33:25Z","timestamp":1788734005000},"source":"Crossref","is-referenced-by-count":0,"special_numbering":"S","title":["Artificial Dermis for Protecting Gastrointestinal Mucosal Defects: A Feasibility Study in ex vivo and in vivo Porcine Models"],"prefix":"10.1055","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1323-416X","authenticated-orcid":false,"given":"Tatsunori","family":"Minamide","sequence":"additional","affiliation":[{"name":"IMSUT Hospital, The University of Tokyo, Tokyo, Japan","place":["Tokyo"],"department":["Department of Gastroenterology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Ikematsu","sequence":"additional","affiliation":[{"name":"IMSUT Hospital, The University of Tokyo, Tokyo, Japan","place":["Tokyo"],"department":["Department of Gastroenterology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeki","family":"Morita","sequence":"additional","affiliation":[{"name":"The Institute of Medical Science, The University of Tokyo, Tokyo, Japan","place":["Tokyo"],"department":["Department of Pathology"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,9,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.cgh.2022.07.029","article-title":"Long-term survival after endoscopic resection for gastric cancer: real-world evidence from a multicenter prospective cohort","volume":"21","author":"H Suzuki","year":"2023","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/den.13246","article-title":"Short-term outcomes of multicenter prospective cohort study of gastric endoscopic resection: \u2018real-world evidence\u2019 in Japan","volume":"31","author":"H Suzuki","year":"2018","journal-title":"Dig Endosc"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1136\/gutjnl-2019-319926","article-title":"Prediction model of bleeding after endoscopic submucosal dissection for early gastric cancer: BEST-J score","volume":"70","author":"W Hatta","year":"2021","journal-title":"Gut"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/den.14466","article-title":"Reopenable clip-over-the-line method for closing large mucosal defects following gastric endoscopic submucosal dissection: prospective feasibility study","volume":"35","author":"T Nomura","year":"2023","journal-title":"Dig Endosc"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/den.14911","article-title":"Endoscopic hand suturing has the potential to reduce bleeding after gastric endoscopic submucosal dissection in patients on antithrombotic agents: Multicenter phase II 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sponge","volume":"53","author":"S Suzuki","year":"2000","journal-title":"Br J Plast Surg"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"35","DOI":"10.7181\/acfs.2018.19.1.35","article-title":"The treatment of post-traumatic facial skin defect with artificial dermis","volume":"19","author":"K S Park","year":"2018","journal-title":"Arch Craniofac Surg"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1111\/jgh.15536","article-title":"Timing of bleeding and thromboembolism associated with endoscopic submucosal dissection for gastric cancer in Japan","volume":"36","author":"S Shiroma","year":"2021","journal-title":"J Gastroenterol Hepatol"}],"container-title":["Endoscopy International 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