{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:04:14Z","timestamp":1790208254856,"version":"4.1.0"},"reference-count":55,"publisher":"Georg Thieme Verlag KG","funder":[{"name":"National Science and Technology Major Project for the Prevention and Treatment of Cancer, Cardiovascular and Cerebrovascular Diseases, Respiratory Diseases and Metabolic Diseases","award":["2024ZD0537904"],"award-info":[{"award-number":["2024ZD0537904"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The systemic immune-inflammation index (SII) is an established prognostic marker in coronary artery disease. This study investigated the association between SII and 1-year prognosis in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI), and explored its potential utility in informing P2Y12 inhibitor selection.<\/jats:p>\n                  <jats:p>A total of 15,123 consecutive ACS patients undergoing PCI between January 2021 and December 2022 were enrolled. Patients were stratified into high- and low-inflammation groups based on the optimal SII cut-off derived from receiver operating characteristic analysis. The primary endpoint was 12-month ischemic events, defined as a composite of cardiac death, myocardial infarction, and stroke. Propensity-score matching was performed to compare ticagrelor-based versus clopidogrel-based dual antiplatelet therapy within each group.<\/jats:p>\n                  <jats:p>The optimal SII cut-off was 651\u2009\u00d7\u2009109\/L. Elevated SII was associated with increased ischemic events (HR 1.86; 95% CI: 1.52\u20132.28; p\u2009&lt;\u20090.0001) and all-cause mortality (HR 2.44; 95% CI: 1.90\u20133.13; p\u2009&lt;\u20090.0001). In the low-SII group (1,422 matched pairs), ticagrelor was associated with increased bleeding risk (HR 2.15; 95% CI: 1.60\u20132.88; p\u2009&lt;\u20090.0001) without association with ischemic benefit. In the high-SII group (1,299 matched pairs), ticagrelor was associated with reduced ischemic events (HR 0.52; 95% CI: 0.33\u20130.83; p\u2009=\u20090.006), cardiac death (HR 0.45; 95% CI: 0.23\u20130.86; p\u2009=\u20090.015), and all-cause mortality (HR 0.40; 95% CI: 0.23\u20130.70; p\u2009=\u20090.001) without association with increased major bleeding.<\/jats:p>\n                  <jats:p>The SII is associated with 12-month post-PCI ischemic and mortality risk and demonstrates potential as a candidate biomarker for risk stratification, with exploratory observations of ticagrelor benefit in high-SII and clopidogrel adequacy in low-SII patients.<\/jats:p>","DOI":"10.1055\/a-2954-8993","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:30:56Z","timestamp":1790206256000},"source":"Crossref","is-referenced-by-count":0,"title":["Ticagrelor vs. Clopidogrel in ACS Patients Underwent PCI: An Analysis Based on Systemic Immune-inflammation Risk Stratification"],"prefix":"10.1055","author":[{"given":"Hengbo","family":"Zhai","sequence":"additional","affiliation":[{"name":"Second Norman Bethune Hospital of Jilin University, Jilin, People's Republic of China","place":["Changchun"],"department":["Department of Cardiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaohan","family":"Qiu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Frigid Zone Cardiovascular Disease, Cardiovascular Research,General Hospital of Northern Theater Command, Liaoning, People's Republic of China","place":["Shenyang"],"department":["Department of Cardiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Na","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Frigid Zone Cardiovascular Disease, Cardiovascular Research,General Hospital of Northern Theater Command, Liaoning, People's Republic of China","place":["Shenyang"],"department":["Department of Cardiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Frigid Zone Cardiovascular Disease, Cardiovascular Research,General Hospital of Northern Theater Command, Liaoning, People's Republic of China","place":["Shenyang"],"department":["Department of Cardiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenghui","family":"Yan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Frigid Zone Cardiovascular Disease, Cardiovascular Research,General Hospital of Northern Theater Command, Liaoning, People's Republic of China","place":["Shenyang"],"department":["Department of Cardiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Frigid Zone Cardiovascular Disease, Cardiovascular Research,General Hospital of Northern Theater Command, Liaoning, People's Republic of China","place":["Shenyang"],"department":["Department of Cardiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaling","family":"Han","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Frigid Zone Cardiovascular Disease, Cardiovascular Research,General Hospital of Northern Theater Command, Liaoning, People's Republic of China","place":["Shenyang"],"department":["Department of Cardiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"issue":"14","key":"ref1","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1093\/eurheartj\/ehaa575","article-title":"2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation","volume":"42","author":"J P Collet","year":"2021","journal-title":"Eur Heart 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Petzold","year":"2022","journal-title":"Immunity"},{"issue":"05","key":"ref34","doi-asserted-by":"crossref","first-page":"e13230","DOI":"10.1111\/eci.13230","article-title":"Systemic immune-inflammation index (SII) predicted clinical outcome in patients with coronary artery disease","volume":"50","author":"Y L Yang","year":"2020","journal-title":"Eur J Clin Invest"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1530534","DOI":"10.3389\/fimmu.2025.1530534","article-title":"SIRI and SII as potential biomarkers of disease activity and lupus nephritis in systemic lupus erythematosus","volume":"16","author":"C H Yang","year":"2025","journal-title":"Front Immunol"},{"issue":"16","key":"ref36","doi-asserted-by":"crossref","first-page":"5205","DOI":"10.2147\/JIR.S435398","article-title":"The systemic inflammation index predicts poor clinical prognosis in patients with initially diagnosed acute coronary syndrome undergoing primary coronary angiography","volume":"16","author":"Y 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