{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:54:54Z","timestamp":1790726094519,"version":"4.1.0"},"reference-count":12,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Nonthyroidal illness syndrome is a common condition among intensive care unit\n                    patients. Previous studies showed conflicting findings regarding association\n                    with poor clinical outcomes. Studies examining whether levothyroxine\n                    administration improves clinical outcomes in critical patients with nonthyroidal\n                    illness syndrome and low free thyroxine levels are lacking. We aimed to examine\n                    whether levothyroxine administration in intensive care unit patients with the\n                    nonthyroidal illness syndrome and low thyroxine levels (&lt;\u20090.8 ng\/dL) resulted\n                    in differences in 28-day mortality and in-hospital morbidity. A retrospective\n                    study using electronic data retrieval for patients admitted to a general\n                    intensive care unit who presented with low free thyroxine levels and\n                    nonthyroidal illness syndrome. This study included 123 patients. A total of 53\n                    patients received levothyroxine. No significant differences were found between\n                    groups regarding demographics, comorbidities or reasons for intensive care unit\n                    admission. Hospital length of stay was significantly longer in the treatment\n                    group (39\u00b124 d) compared to that in the non-treatment group (30\u00b119 d;\n                    p&lt;0.05). The duration of mechanical ventilation was significantly\n                    longer in the treatment group (21\u00b121 d) vs. non-treatment group (14\u00b114 d;\n                        p&lt;0.05). Intensive care unit length of stay showed a trend toward\n                    being longer in the treatment group (22\u00b120 d) compared to that in the\n                    non-treatment group (16\u00b113 d; p=0.058). Higher free thyroxine levels were\n                    associated with better clinical outcomes, including the reduced need for\n                    vasopressors and dialysis, and lower 28-day mortality. Low free thyroxine levels\n                    in intensive care unit patients with nonthyroidal illness syndrome are\n                    associated with higher morbidity. Levothyroxine administration did not improve\n                    clinical outcomes in this population.<\/jats:p>","DOI":"10.1055\/a-2961-7316","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:55:38Z","timestamp":1790722538000},"source":"Crossref","is-referenced-by-count":0,"title":["Levothyroxine Administration in Intensive Care Unit Patients with Low\n                    Thyroxine Levels: A Retrospective Comparison Study"],"prefix":"10.1055","clinical-trial-number":[{"clinical-trial-number":"nct06154382","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Aviv","family":"Benedick","sequence":"additional","affiliation":[{"name":"Meir Medical Center, Center District, Israel","place":["Kefar Sava"],"department":["Anesthesia and critical care"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avraham","family":"Meyer","sequence":"additional","affiliation":[{"name":"Meir Medical Center, Center District, Israel","place":["Kefar Sava"],"department":["Anesthesia and intensive care"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elad","family":"Dana","sequence":"additional","affiliation":[{"name":"Meir Medical Center, Center District, Israel","place":["Kefar Sava"],"department":["Anesthesia and critical care"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Dichtwald","sequence":"additional","affiliation":[{"name":"Meir Medical Center, Center District, Israel","place":["Kefar Sava"],"department":["Anesthesia and critical care"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1053\/beem.2001.0160","article-title":"The neuroendocrine response to stress is a dynamic process","volume":"15","author":"G Van den Berghe","year":"2001","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1001\/jama.1981.03310260021020","article-title":"Hypothyroxinemia in critically ill patients as a predictor of high\n                    mortality","volume":"245","author":"M F Slag","year":"1981","journal-title":"JAMA"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1097\/00003246-199501000-00015","article-title":"Prediction of outcome in intensive care patients using endocrine parameters","volume":"23","author":"P M Rothwell","year":"1995","journal-title":"Crit Care Med"},{"key":"ref4","first-page":"395","article-title":"Changes in the hypophyseal-thyroid axis and their prognostic value in sepsis [in\n                    Spanish]","volume":"187","author":"A Mangas-Rojas","year":"1990","journal-title":"Rev Clin Esp"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1530\/EJE-10-0695","article-title":"Association between thyroid function tests at baseline and 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predictor of outcome in respiratory failure?\n                    Results of a clinical pilot study","volume":"151","author":"E Scoscia","year":"2004","journal-title":"Eur J Endocrinol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1378\/chest.08-1816","article-title":"Nonthyroidal illness syndrome and prolonged mechanical ventilation in patients\n                    admitted to the ICU","volume":"135","author":"G Bello","year":"2009","journal-title":"Chest"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"R11","DOI":"10.1186\/cc11151","article-title":"Relationship between thyroid function and ICU mortality: a prospective\n                    observation study","volume":"16","author":"F Wang","year":"2012","journal-title":"Crit Care"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1007\/s00134-002-1427-y","article-title":"Endocrine measurements in survivors and non-survivors from critical illness","volume":"28","author":"D C Ray","year":"2002","journal-title":"Intensive Care Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1089\/thy.1992.2.119","article-title":"Do thyroid function tests independently predict survival in the critically\n                    ill?","volume":"2","author":"L S Maldonado","year":"1992","journal-title":"Thyroid"}],"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2961-7316.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:55:39Z","timestamp":1790722539000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2961-7316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,29]]},"references-count":12,"URL":"https:\/\/doi.org\/10.1055\/a-2961-7316","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,29]]}}}