{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T23:59:32Z","timestamp":1790380772870,"version":"4.1.0"},"reference-count":20,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Facial Plast Surg"],"abstract":"Abstract<\/jats:title>\n Autologous biofillers are emerging blood-derived regenerative treatments for soft tissue augmentation and regeneration. Despite increasing use, there is limited consensus regarding their definition, preparation, mechanisms, indications, efficacy, longevity, and safety.<\/jats:p>\n To systematically review the literature, providing an evidence-based overview of biofillers and informing clinical practice. We hypothesize that blood-derived biofillers are a safe and effective regenerative treatment for facial soft tissue augmentation.<\/jats:p>\n A systematic review of the literature.<\/jats:p>\n Studies evaluating autologous blood-derived biofillers for facial soft tissue augmentation were included. Data on definition, preparation, indications, outcomes, longevity, and safety were synthesized narratively.<\/jats:p>\n Twenty studies were included. Biofillers were primarily used for facial rejuvenation, infraorbital restoration, wrinkle reduction, and skin improvement. Clinical outcomes and patient satisfaction were favorable, while adverse events were predominantly mild and transient. Heterogeneity in terminology, preparation, and outcome reporting precluded meta-analysis.<\/jats:p>\n Autologous biofillers are promising, with encouraging clinical outcomes and a favorable safety profile, but further studies are required to define their role in aesthetic practice.<\/jats:p>","DOI":"10.1055\/a-2962-4787","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T23:03:39Z","timestamp":1789772619000},"source":"Crossref","is-referenced-by-count":0,"title":["Autologous Biofiller in Aesthetic and Regenerative Medicine: A Systematic Review"],"prefix":"10.1055","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3037-9014","authenticated-orcid":false,"given":"Hanna","family":"D'Souza","sequence":"additional","affiliation":[{"name":"King's College London, School of Medicine, United Kingdom of Great Britain and Northern Ireland","place":["London"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3143-7099","authenticated-orcid":false,"given":"Mashael","family":"AlKandery","sequence":"additional","affiliation":[{"name":"Kuwait Institute for Medical Specialization, Kuwait","place":["Andalous"],"department":["Department of Otolaryngology-Facial Plastic Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishi","family":"Mandavia","sequence":"additional","affiliation":[{"name":"Drs Tatiana + Rishi Advanced Aesthetics, United Kingdom of Great Britain and Northern Ireland","place":["London"],"department":["Department of Facial Plastic Surgery"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,9,25]]},"reference":[{"issue":"05","key":"ref1","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1055\/a-2849-8705","article-title":"Periocular rejuvenation with PRF gel","volume":"42","author":"S Rahbari","year":"2026","journal-title":"Facial Plast Surg"},{"issue":"01","key":"ref2","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/prd.12582","article-title":"Autolougous platelet concentrates in esthetic medicine","volume":"97","author":"C Davies","year":"2025","journal-title":"Periodontol 2000"},{"issue":"01","key":"ref3","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/prd.12537","article-title":"Extended platelet-rich fibrin","volume":"94","author":"R J Miron","year":"2024","journal-title":"Periodontol 2000"},{"issue":"10","key":"ref4","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1111\/jocd.13322","article-title":"Plasma rich in growth factor gel as an autologous filler for facial volume restoration","volume":"19","author":"L Godfrey","year":"2020","journal-title":"J Cosmet 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(Lausanne)"},{"issue":"04","key":"ref11","doi-asserted-by":"crossref","first-page":"321","DOI":"10.23736\/S2784-8671.23.07485-6","article-title":"The innovative application of autologous biofillers in aesthetic dermatology","volume":"158","author":"R Amiri","year":"2023","journal-title":"Ital J Dermatol Venereol"},{"issue":"06","key":"ref12","first-page":"e14255","article-title":"Platelet-poor plasma gel vs platelet-rich plasma for infraorbital rejuvenation: A clinical and dermoscopic comparative study","volume":"33","author":"Y ME Neinaa","year":"2020","journal-title":"Dermatol Ther"},{"issue":"05","key":"ref13","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1111\/jocd.12876","article-title":"Assessment of the efficacy and safety of platelet poor plasma gel as autologous dermal filler for facial rejuvenation","volume":"18","author":"N N Doghaim","year":"2019","journal-title":"J Cosmet Dermatol"},{"issue":"01","key":"ref14","doi-asserted-by":"crossref","first-page":"56","DOI":"10.55519\/JAMC-01-12585","article-title":"Biofiller vs platelet-rich plasma mesotherapy in the treatment of peri-orbital hyperpigmentation","volume":"36","author":"S Sadiq","year":"2024","journal-title":"J Ayub Med Coll Abbottabad"},{"issue":"03","key":"ref15","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1080\/14764172.2016.1248443","article-title":"A clinical study on the usefulness of autologous plasma filler in the treatment of nasolabial fold wrinkles","volume":"19","author":"Y J Choi","year":"2017","journal-title":"J Cosmet Laser Ther"},{"issue":"07","key":"ref16","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s00403-021-02270-7","article-title":"Efficacy and safety of plasma gel versus platelet-rich plasma in periorbital rejuvenation: a comparative split-face clinical and Antera 3D camera study","volume":"314","author":"H M Diab","year":"2022","journal-title":"Arch Dermatol Res"},{"issue":"03","key":"ref17","doi-asserted-by":"crossref","first-page":"243","DOI":"10.4103\/JCAS.JCAS_172_19","article-title":"Bio-filler: an effective facial rejuvenation tool-easy on pocket","volume":"13","author":"S Gupta","year":"2020","journal-title":"J Cutan Aesthet Surg"},{"issue":"02","key":"ref18","doi-asserted-by":"crossref","first-page":"117","DOI":"10.66344\/jpad.v35i2.3127","article-title":"A comprehensive evaluation of biofillers for infraorbital rejuvenation","volume":"35","author":"B Muneeb","year":"2025","journal-title":"J Pak Assoc Dermatol"},{"issue":"01","key":"ref19","doi-asserted-by":"crossref","first-page":"9989544","DOI":"10.1155\/2023\/9989544","article-title":"Autologous plasma gel as an effective method of facial volume restoration and skin rejuvenation","volume":"2023","author":"L Majewska","year":"2023","journal-title":"Dermatol 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