{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T23:57:48Z","timestamp":1790639868891,"version":"4.1.0"},"reference-count":33,"publisher":"Georg Thieme Verlag KG","funder":[{"name":"Institute of Circulatory and Respiratory Health","award":["452367"],"award-info":[{"award-number":["452367"]}],"id":[{"id":"https:\/\/ror.org\/00bhv3b03","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"abstract":"<jats:p>Patients with cancer have an increased risk of venous thromboembolism (VTE). This risk is further elevated in those with a central venous catheter (CVC). Previous studies have shown that prophylactic doses of direct oral anticoagulants (DOACs) reduce the risk of VTE in ambulatory cancer patients starting chemotherapy, which has led to recommendations from international clinical guidelines to use DOACs as primary thromboprophylaxis in this population. Primary thromboprophylaxis after CVC insertion is not recommended due to a lack of definitive evidence. As such, the TRIM-Line trial randomized 1,828 patients with active cancer and a newly inserted CVC to rivaroxaban 10\u2009mg daily versus placebo. The primary efficacy outcome was the first objectively confirmed symptomatic or incidental major VTE (proximal upper or lower extremity deep vein thrombosis and\/or pulmonary embolism) within 90 days of randomization. The primary safety outcome was major bleeding, as defined by the International Society on Thrombosis and Haemostasis criteria, within 90 days. The key secondary outcomes included clinically relevant non-major bleeding, arterial thrombosis, and overall mortality. The study provides high-quality evidence to address a key knowledge gap regarding the benefits and risks of thromboprophylaxis in patients with active cancer and an indwelling CVC (NCT05029063).<\/jats:p>","DOI":"10.1055\/a-2963-4656","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:54:38Z","timestamp":1790031278000},"source":"Crossref","is-referenced-by-count":0,"title":["Primary Thromboprophylaxis in Patients with Malignancy and Central Venous Catheters: TRIM-Line Randomized Controlled Trial\u2014Design and Rationale"],"prefix":"10.1055","clinical-trial-number":[{"clinical-trial-number":"nct05029063","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2407-9000","authenticated-orcid":false,"given":"Tzu-Fei","family":"Wang","sequence":"additional","affiliation":[{"name":"University of Ottawa at The Ottawa Hospital and Ottawa Hospital Research Institute, Ontario, Canada","place":["Ottawa"],"department":["Department of Medicine, Division of Hematology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick","family":"Ikesaka","sequence":"additional","affiliation":[{"name":"Vancouver General Hospital and The University of British Columbia, British Columbia, Canada","place":["Vancouver"],"department":["Department of Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1760-7880","authenticated-orcid":false,"given":"Isabelle","family":"Mah\u00e9","sequence":"additional","affiliation":[{"name":"Assistance Publique-H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Louis Mourier, \u00cele-de-France, France","place":["Colombes"],"department":["Service de M\u00e9decine Interne"]},{"name":"Universit\u00e9 Paris Cit\u00e9, France","place":["Paris"],"department":["Department of Medicine"]},{"name":"Team Endotheliopathy and Hemostasis Disorders, Paris Cardiovascular Research Center, INSERM UMR-S970, France","place":["Paris"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny","family":"Hill","sequence":"additional","affiliation":[{"name":"Sault Area Hospital, Ontario, Canada","place":["Sault Ste. Marie"],"department":["Department of Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Sperlich","sequence":"additional","affiliation":[{"name":"CISSS Mont\u00e9r\u00e9gie-Centre\/H\u00f4pital Charles-Le Moyne, Qu\u00e9bec, Canada","place":["Greenfield Park"],"department":["Division of Hematology and Oncology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicky","family":"Tagalakis","sequence":"additional","affiliation":[{"name":"Lady Davis Institute for Medical Research, Qu\u00e9bec, Canada","place":["Montreal"],"department":["Department of Epidemiology"]},{"name":"McGill University, Qu\u00e9bec, Canada","place":["Montreal"],"department":["Department of Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudeep","family":"Shivakumar","sequence":"additional","affiliation":[{"name":"Nova Scotia Health, Dalhousie University, Canada","place":["Halifax"],"department":["Department of Medicine, Division of Hematology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blair","family":"Leonard","sequence":"additional","affiliation":[{"name":"Niagara Health System, Ontario, Canada","place":["St. Catharines"],"department":["Department of Oncology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Cervi","sequence":"additional","affiliation":[{"name":"Windsor Regional Cancer Centre, Ontario, Canada","place":["Windsor"],"department":["Department of Oncology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip G.","family":"Kuruvilla","sequence":"additional","affiliation":[{"name":"William Osler Health System, Ontario, Canada","place":["Brampton"],"department":["Department of Hematology\/Oncology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9deric","family":"Larose","sequence":"additional","affiliation":[{"name":"H\u00f4tel-Dieu de L\u00e9vis, CISSS de Chaudi\u00e8res-Appalaches, Qu\u00e9bec, Canada","place":["Levis"],"department":["Division of Hematology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Matino","sequence":"additional","affiliation":[{"name":"McMaster University, Ontario, Canada","place":["Hamilton"],"department":["Department of Medicine, Division of Hematology and Thromboembolism"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffan Frosi","family":"Stella","sequence":"additional","affiliation":[{"name":"McMaster University, Ontario, Canada","place":["Hamilton"],"department":["Department of Medical Imaging, Division of Vascular and Interventional Radiology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal","family":"S\u00e9guin","sequence":"additional","affiliation":[{"name":"McGill University Health Center, Qu\u00e9bec, Canada","place":["Montr\u00e9al"],"department":["Department of Medicine, Division of Hematology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulrahman","family":"Al Raizah","sequence":"additional","affiliation":[{"name":"King Abdullah International Medical Research Center, King Saud bin Abdulaziz University of Health Sciences, Riyadh Province, Saudi Arabia","place":["Riyadh"],"department":["Department of Oncology, Ministry of National Guard Health Affairs"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9goire","family":"Le Gal","sequence":"additional","affiliation":[{"name":"University of Ottawa at The Ottawa Hospital and Ottawa Hospital Research Institute, Ontario, Canada","place":["Ottawa"],"department":["Department of Medicine, Division of Hematology"]},{"name":"University of Ottawa, Ontario, Canada","place":["Ottawa"],"department":["Thrombosis Program, Department of Medicine, Division of Hematology"]},{"name":"Ottawa Health Research Institute, Ontario, Canada","place":["Ottawa"],"department":["Clinical Epidemiology Unit"]},{"name":"Universit\u00e9 de Bretagne Occidentale, Bretagne, France","place":["Brest"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah M.","family":"Siegal","sequence":"additional","affiliation":[{"name":"University of Ottawa at The Ottawa Hospital and Ottawa Hospital Research Institute, Ontario, Canada","place":["Ottawa"],"department":["Department of Medicine, Division of Hematology"]},{"name":"University of Ottawa, Canada","place":["Ottawa"],"department":["Department of Medicine"]},{"name":"Ottawa Hospital Research Institute, Ontario, Canada","place":["Ottawa"],"department":["Clinical Epidemiology Program"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0227-1245","authenticated-orcid":false,"given":"Aur\u00e9lien","family":"Delluc","sequence":"additional","affiliation":[{"name":"University of Ottawa at The Ottawa Hospital and Ottawa Hospital Research Institute, Ontario, Canada","place":["Ottawa"],"department":["Department of Medicine, Division of Hematology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjeeta","family":"Mallick","sequence":"additional","affiliation":[{"name":"School of Epidemiology and Public Health, University of Ottawa, Ontario, Canada","place":["Ottawa"]},{"name":"Ottawa Methods Centre, Ottawa Hospital Research Institute, Ontario, Canada","place":["Ottawa"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6869-8431","authenticated-orcid":false,"given":"Alejandro","family":"Lazo-Langner","sequence":"additional","affiliation":[{"name":"Western University, Ontario, Canada","place":["London"],"department":["Department of Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Wu","sequence":"additional","affiliation":[{"name":"University of Alberta, Alberta, Canada","place":["Edmonton"],"department":["Department of Medicine, Division of Hematology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Christopher","sequence":"additional","affiliation":[{"name":"Queen's University, Canada","place":["Kingston"],"department":["Department of Medicine"]},{"name":"Canadian Venous Thromboembolism Research Network (CanVECTOR), Qu\u00e9bec, Canada","place":["Montr\u00e9al"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5930-7304","authenticated-orcid":false,"given":"Marcello","family":"Di Nisio","sequence":"additional","affiliation":[{"name":"University G. D'Annunzio Chieti-Pescara, Abruzzo, Italy","place":["Chieti"],"department":["Department of Medicine and Ageing Sciences"]},{"name":"Academic Medical Centre, Netherlands","place":["Amsterdam"],"department":["Department of Vascular Medicine"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Ageno","sequence":"additional","affiliation":[{"name":"University of Padua, Veneto, Italy","place":["Padua"],"department":["Department of Medicine, Emergency Medicine Unit"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bashour","family":"Yazji","sequence":"additional","affiliation":[{"name":"University of Ottawa at The Ottawa Hospital and Ottawa Hospital Research Institute, Ontario, Canada","place":["Ottawa"],"department":["Department of Medicine, Division of Hematology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Carrier","sequence":"additional","affiliation":[{"name":"University of Ottawa at The Ottawa Hospital and Ottawa Hospital Research Institute, Ontario, Canada","place":["Ottawa"],"department":["Department of Medicine, Division of Hematology"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1160\/TH15-08-0686","article-title":"Epidemiology of first and recurrent venous thromboembolism in patients with active cancer. A population-based cohort study","volume":"117","author":"A T Cohen","year":"2017","journal-title":"Thromb Haemost"},{"issue":"06","key":"ref2","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.thromres.2009.12.023","article-title":"Venous thromboembolism and prognosis in cancer","volume":"125","author":"A A Khorana","year":"2010","journal-title":"Thromb Res"},{"issue":"03","key":"ref3","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1111\/j.1538-7836.2007.02374.x","article-title":"Thromboembolism is a leading cause of death in cancer patients receiving outpatient chemotherapy","volume":"5","author":"A A Khorana","year":"2007","journal-title":"J Thromb Haemost"},{"issue":"04","key":"ref4","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.jval.2017.09.015","article-title":"What impact does venous thromboembolism and bleeding have on cancer patients' quality of life?","volume":"21","author":"A J Lloyd","year":"2018","journal-title":"Value Health"},{"issue":"14","key":"ref5","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1056\/NEJMc1408861","article-title":"Anticoagulation for central venous catheters in patients with cancer","volume":"371","author":"L D'Ambrosio","year":"2014","journal-title":"N Engl J Med"},{"issue":"04","key":"ref6","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1182\/bloodadvances.2020003442","article-title":"American Society of Hematology 2021 guidelines for management of venous thromboembolism: prevention and treatment in patients with cancer","volume":"5","author":"G H Lyman","year":"2021","journal-title":"Blood Adv"},{"issue":"16","key":"ref7","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1200\/JCO.23.00294","article-title":"Venous thromboembolism prophylaxis and treatment in patients with cancer: ASCO Guideline Update","volume":"41","author":"N S Key","year":"2023","journal-title":"J Clin Oncol"},{"issue":"10","key":"ref8","first-page":"1181","article-title":"Cancer-associated venous thromboembolic disease, version 2.2021, NCCN Clinical Practice Guidelines in Oncology","volume":"19","author":"M B Streiff","year":"2021","journal-title":"J Natl Compr Canc Netw"},{"issue":"08","key":"ref9","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1056\/NEJMoa1814468","article-title":"Apixaban to prevent venous thromboembolism in patients with cancer","volume":"380","author":"M Carrier","year":"2019","journal-title":"N Engl J Med"},{"issue":"08","key":"ref10","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1056\/NEJMoa1814630","article-title":"Rivaroxaban for Thromboprophylaxis in high-risk ambulatory patients with cancer","volume":"380","author":"A A Khorana","year":"2019","journal-title":"N Engl J Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.thromres.2022.05.014","article-title":"Efficacy and safety of apixaban for primary prevention of thromboembolism in patients with cancer and a central venous catheter: A subgroup analysis of the AVERT Trial","volume":"216","author":"W Brandt","year":"2022","journal-title":"Thromb Res"},{"issue":"04","key":"ref12","doi-asserted-by":"crossref","first-page":"e12517","DOI":"10.1002\/rth2.12517","article-title":"Thromboprophylaxis with rivaroxaban in patients with malignancy and central venous lines (TRIM-Line): A two-center open-label pilot randomized controlled trial","volume":"5","author":"R Ikesaka","year":"2021","journal-title":"Res Pract Thromb Haemost"},{"issue":"04","key":"ref13","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1378\/chest.10-0154","article-title":"Risk of symptomatic DVT associated with peripherally inserted central catheters","volume":"138","author":"R S Evans","year":"2010","journal-title":"Chest"},{"issue":"02","key":"ref14","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/j.1538-7836.2010.04126.x","article-title":"Risk factors for catheter-related thrombosis (CRT) in cancer patients: a patient-level data (IPD) meta-analysis of clinical trials and prospective studies","volume":"9","author":"W Saber","year":"2011","journal-title":"J Thromb Haemost"},{"issue":"06","key":"ref15","first-page":"CD006468","article-title":"Anticoagulation for people with cancer and central venous catheters","volume":"6","author":"L A Kahale","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"issue":"04","key":"ref16","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/j.1538-7836.2005.01204.x","article-title":"Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients","volume":"3","author":"S Schulman","year":"2005","journal-title":"J Thromb Haemost"},{"issue":"11","key":"ref17","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1111\/jth.13140","article-title":"Definition of clinically relevant non-major bleeding in studies of anticoagulants in atrial fibrillation and venous thromboembolic disease in non-surgical patients: communication from the SSC of the ISTH","volume":"13","author":"S Kaatz","year":"2015","journal-title":"J Thromb Haemost"},{"issue":"10","key":"ref18","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1111\/jth.14564","article-title":"The use of direct oral anticoagulants for primary thromboprophylaxis in ambulatory cancer patients: Guidance from the SSC of the ISTH","volume":"17","author":"T F Wang","year":"2019","journal-title":"J Thromb Haemost"},{"issue":"12","key":"ref19","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1056\/NEJMra011883","article-title":"Preventing complications of central venous catheterization","volume":"348","author":"D C McGee","year":"2003","journal-title":"N Engl J Med"},{"issue":"11","key":"ref20","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1111\/jth.15487","article-title":"Venous thromboembolism associated with central venous catheters in patients with cancer: From pathophysiology to thromboprophylaxis, areas for future studies","volume":"19","author":"P Debourdeau","year":"2021","journal-title":"J Thromb Haemost"},{"issue":"02","key":"ref21","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1148\/radiol.2402031129","article-title":"Jugular vein catheter placement: histologic features and development of catheter-related (fibrin) sheaths in a swine model","volume":"240","author":"A R Forauer","year":"2006","journal-title":"Radiology"},{"issue":"19","key":"ref22","doi-asserted-by":"crossref","first-page":"3665","DOI":"10.1200\/JCO.2003.08.008","article-title":"Venous thromboembolism associated with long-term use of central venous catheters in cancer patients","volume":"21","author":"M Verso","year":"2003","journal-title":"J Clin Oncol"},{"issue":"9889","key":"ref23","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0140-6736(13)60592-9","article-title":"Risk of venous thromboembolism associated with peripherally inserted central catheters: a systematic review and meta-analysis","volume":"382","author":"V Chopra","year":"2013","journal-title":"Lancet"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.thromres.2021.10.012","article-title":"Efficacy and safety of primary thromboprophylaxis for the prevention of venous thromboembolism in patients with cancer and a central venous catheter: A systematic review and meta-analysis","volume":"208","author":"A Li","year":"2021","journal-title":"Thromb Res"},{"issue":"05","key":"ref25","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1200\/JCO.19.01461","article-title":"Venous thromboembolism prophylaxis and treatment in patients with cancer: ASCO Clinical Practice Guideline Update","volume":"38","author":"N S Key","year":"2020","journal-title":"J Clin Oncol"},{"issue":"01","key":"ref26","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1161\/ATVBAHA.123.319692","article-title":"Factor XI inhibition for the prevention of catheter-associated thrombosis in patients with cancer undergoing central line placement: a phase 2 clinical trial","volume":"44","author":"M A Pfeffer","year":"2024","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.4081\/btvb.2026.542","article-title":"Sub-analysis of the interim results from a Phase 2 study investigating REGN9933A2 and REGN7508CAT for the prevention of contact-mediated venous thromboembolism in patients with active cancer undergoing peripherally inserted central catheter placement (ROXI-CATH)","volume":"5","author":"J Zwicker","year":"2026","journal-title":"Bleeding Thromb Vasc Biol"},{"issue":"02","key":"ref28","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1055\/s-0038-1650254","article-title":"Upper extremity deep venous thrombosis in cancer patients with venous access devices--prophylaxis with a low molecular weight heparin (Fragmin)","volume":"75","author":"M Monreal","year":"1996","journal-title":"Thromb Haemost"},{"issue":"18","key":"ref29","doi-asserted-by":"crossref","first-page":"4057","DOI":"10.1200\/JCO.2005.06.084","article-title":"Enoxaparin for the prevention of venous thromboembolism associated with central vein catheter: a double-blind, placebo-controlled, randomized study in cancer patients","volume":"23","author":"M Verso","year":"2005","journal-title":"J Clin Oncol"},{"issue":"02","key":"ref30","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/annonc\/mdj059","article-title":"Dalteparin for prevention of catheter-related complications in cancer patients with central venous catheters: final results of a double-blind, placebo-controlled phase III trial","volume":"17","author":"M Karthaus","year":"2006","journal-title":"Ann Oncol"},{"issue":"12","key":"ref31","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1093\/annonc\/mdp235","article-title":"Early and short-term acenocumarine or dalteparin for the prevention of central vein catheter-related thrombosis in cancer patients: a randomized controlled study based on serial venographies","volume":"20","author":"M De Cicco","year":"2009","journal-title":"Ann Oncol"},{"issue":"09","key":"ref32","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1111\/j.1538-7836.2007.02660.x","article-title":"Prevention of catheter-related venous thrombosis with nadroparin in patients receiving chemotherapy for hematologic malignancies: a randomized, placebo-controlled study","volume":"5","author":"T M Niers","year":"2007","journal-title":"J Thromb Haemost"},{"issue":"01","key":"ref33","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s00280-013-2169-y","article-title":"Prophylaxis of catheter-related deep vein thrombosis in cancer patients with low-dose warfarin, low molecular weight heparin, or control: a randomized, controlled, phase III study","volume":"72","author":"S Lavau-Denes","year":"2013","journal-title":"Cancer Chemother Pharmacol"}],"container-title":["Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2963-4656.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T23:12:11Z","timestamp":1790637131000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2963-4656"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,21]]},"references-count":33,"URL":"https:\/\/doi.org\/10.1055\/a-2963-4656","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0340-6245","2567-689X"],"issn-type":[{"value":"0340-6245","type":"print"},{"value":"2567-689X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,9,21]]},"published":{"date-parts":[[2026,9,21]]}}}