{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:05:06Z","timestamp":1790809506446,"version":"4.1.0"},"reference-count":13,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We aimed to evaluate the frequency and characteristics of headaches across pregnancy and to examine obstetric and neonatal outcomes among pregnant patients with recurrent migraines.<\/jats:p>\n                  <jats:p>This was a single-site prospective observational study of pregnant patients evaluated for recurrent headaches during prenatal visits from December 2020 through September 2022. Standardized questions were used at each visit to assess headache type, frequency, and associated symptoms. Obstetric and neonatal outcomes were recorded. Statistical analyses included mixed effects logistic regression, independent t-tests, and chi-square tests to compare baseline characteristics and outcomes between groups.<\/jats:p>\n                  <jats:p>During the study period, 858 pregnant patients were evaluated for recurrent headaches. Of these, 546 (63.6%) patients were diagnosed with migraine headaches and 312 (36.4%) with tension-type headaches. Migraine frequency was highest in the second trimester. Nausea, vomiting, and photophobia were the most commonly reported associated symptoms. In the first trimester, 58.7% of patients reported nausea, 59.4% photophobia, and 31.0% vomiting. The frequency of these symptoms decreased with advancing gestation. The composite outcome of preterm delivery, preeclampsia with severe features, abruption, and stillbirth did not significantly differ between patients with migraines and matched controls without headache disorders (25.4 vs. 21.1%, p\u2009=\u20090.12). There were no significant differences in individual components of the composite outcome or in neonatal outcomes, including birthweight &lt;\u20093%ile, birthweight &lt;\u200910%ile, and need for neonatal respiratory support.<\/jats:p>\n                  <jats:p>Migraines were the most common headache diagnosis among pregnant patients with recurrent headaches, and migraine frequency and associated symptoms changed across gestation. After adjustment for comorbid conditions, obstetric and neonatal outcomes were similar between patients with recurrent migraines and those without headache disorders.<\/jats:p>","DOI":"10.1055\/a-2963-5766","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:55:28Z","timestamp":1790031328000},"source":"Crossref","is-referenced-by-count":0,"title":["Migraines in Pregnancy: A Prospective Study of Symptom Patterns and Obstetric Outcomes"],"prefix":"10.1055","author":[{"given":"Rachel C.","family":"Schell","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center, Texas, United States","place":["Dallas"],"department":["Department of Obstetrics and Gynecology"]},{"name":"Parkland Health, Texas, United States","place":["Dallas"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8387-9457","authenticated-orcid":false,"given":"Gayathri D.","family":"Vadlamudi","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center, Texas, United States","place":["Dallas"],"department":["Department of Obstetrics and Gynecology"]},{"name":"Parkland Health, Texas, United States","place":["Dallas"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia S.","family":"Edwards","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center, Texas, United States","place":["Dallas"],"department":["Department of Obstetrics and Gynecology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmeen","family":"Alayli","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center, Texas, United States","place":["Dallas"],"department":["Department of Obstetrics and Gynecology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devin A.","family":"Macias","sequence":"additional","affiliation":[{"name":"Sutter Medical Group, California, United States","place":["Sacramento"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"April R.","family":"Gorman","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center, Texas, United States","place":["Dallas"],"department":["Department of Obstetrics and Gynecology"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Bryan","family":"Nelson","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center, Texas, United States","place":["Dallas"],"department":["Department of Obstetrics and Gynecology"]},{"name":"Parkland Health, Texas, United States","place":["Dallas"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine Y.","family":"Spong","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center, Texas, United States","place":["Dallas"],"department":["Department of Obstetrics and Gynecology"]},{"name":"Parkland Health, Texas, United States","place":["Dallas"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6040-7430","authenticated-orcid":false,"given":"Elaine L.","family":"Duryea","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center, Texas, United States","place":["Dallas"],"department":["Department of Obstetrics and Gynecology"]},{"name":"Parkland Health, Texas, United States","place":["Dallas"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"issue":"01","key":"ref1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1097\/AOG.0000000000003322","article-title":"Migraine and other headache disorders: ACOG clinical updates in women's health care primary and preventive care review summary Volume XVIII, Number 4","volume":"134","author":"S Lucas","year":"2019","journal-title":"Obstet Gynecol"},{"issue":"05","key":"ref2","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1097\/AOG.0000000000004766","article-title":"Headaches in pregnancy and postpartum: ACOG Clinical Practice Guideline No. 3","volume":"139","year":"2022","journal-title":"Obstet Gynecol"},{"issue":"04","key":"ref3","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s11916-011-0200-8","article-title":"Headaches during pregnancy","volume":"15","author":"R E Nappi","year":"2011","journal-title":"Curr Pain Headache Rep"},{"issue":"01","key":"ref4","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/head.13665","article-title":"Epidemiology and treatment of menstrual migraine and migraine during pregnancy and lactation: a narrative review","volume":"60","author":"R Burch","year":"2020","journal-title":"Headache"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/B978-0-444-64240-0.00011-8","article-title":"Migraine and other headache disorders in pregnancy","volume":"172","author":"D S van Casteren","year":"2020","journal-title":"Handb Clin Neurol"},{"issue":"12","key":"ref6","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1097\/OGX.0000000000000738","article-title":"Associations between migraine and adverse pregnancy outcomes: systematic review and meta-analysis","volume":"74","author":"A M Aukes","year":"2019","journal-title":"Obstet Gynecol Surv"},{"issue":"03","key":"ref7","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/j.1468-2982.2008.01704.x","article-title":"Migraine is a risk factor for hypertensive disorders in pregnancy: a prospective cohort study","volume":"29","author":"F Facchinetti","year":"2009","journal-title":"Cephalalgia"},{"issue":"03","key":"ref8","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.ajog.2022.04.049","article-title":"Migraine and adverse pregnancy outcomes: the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-be","volume":"227","author":"E C Miller","year":"2022","journal-title":"Am J Obstet Gynecol"},{"issue":"04","key":"ref9","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1468-2982.2009.01935.x","article-title":"Increased risk of adverse pregnancy outcomes for women with migraines: a nationwide population-based study","volume":"30","author":"H M Chen","year":"2010","journal-title":"Cephalalgia"},{"issue":"06","key":"ref10","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1111\/head.13536","article-title":"Pregnancy, birth, neonatal, and postnatal neurological outcomes after pregnancy with migraine","volume":"59","author":"N Skajaa","year":"2019","journal-title":"Headache"},{"issue":"03","key":"ref11","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1212\/01.WNL.0000078940.53438.83","article-title":"A self-administered screener for migraine in primary care: the ID Migraine validation study","volume":"61","author":"R B Lipton","year":"2003","journal-title":"Neurology"},{"issue":"01","key":"ref12","first-page":"1","article-title":"The International Classification of Headache Disorders","volume":"38","author":"Headache Classification Committee of the International Headache Society (IHS)","year":"2018","journal-title":"Cephalalgia"},{"issue":"06","key":"ref13","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1055\/s-0038-1673681","article-title":"Headache in pregnancy, the puerperium, and menopause","volume":"38","author":"E Sader","year":"2018","journal-title":"semin neurol"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-2963-5766.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:38:03Z","timestamp":1790807883000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-2963-5766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,21]]},"references-count":13,"URL":"https:\/\/doi.org\/10.1055\/a-2963-5766","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,9,21]]},"published":{"date-parts":[[2026,9,21]]}}}