{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:52:45Z","timestamp":1791589965085,"version":"4.3.4"},"reference-count":11,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Introduction This report describes our experience with PRESERFLO MicroShunt implantation with and without adjunctive subconjunctival Healaflow\u00ae as a modified bleb-forming filtration technique in glaucoma patients.<\/jats:p>\n                  <jats:p>Materials and methods A retrospective cohort analysis of 65 consecutive eyes undergoing single PRESERFLO MicroShunt implantation at a single center was performed. The Healaflow group (HG; n = 36, with Healaflow\u00ae) was operated between October 2024 and July 2025, and the control group (CG; n = 29, without Healaflow\u00ae) between October 2018 and December 2019. Medical records were reviewed for demographics, intraocular pressure (IOP), medication use and complications. IOP and topical medication were compared between groups preoperatively, on day 1, week 1, and at 1\u20133, 3\u20136, 6\u201312 and 12\u201318 months using unpaired t-tests and a two-way repeated-measures ANOVA.<\/jats:p>\n                  <jats:p>Results Mean preoperative IOP was comparable between groups (24.4 \u00b1 9.4 vs. 21.8 \u00b1 8.2 mmHg; p = 0.24). IOP was significantly lower in the HG at 1\u20133 months (8.6 \u00b1 4.0 vs. 14.0 \u00b1 9.2; p = 0.007), 3\u20136 months (10.4 \u00b1 5.4 vs. 14.9 \u00b1 7.1; p = 0.031) and 6\u201312 months (11.0 \u00b1 4.0 vs. 15.4 \u00b1 5.3; p = 0.004), and remained nominally lower at 12\u201318 months (11.6 \u00b1 6.0 vs. 13.8 \u00b1 5.3; p = 0.254). The ANOVA showed a significant group-by-time interaction (p = 0.001) in favour of the HG. Topical medication was consistently lower in the HG (6\u201312 months: 0.41 vs. 1.38 compounds). Transient, self-limiting hypotony-related choroidal detachment\/effusion occurred in 27.8% (HG) vs. 13.8% (CG); bleb revision was required in 8.3% vs. 13.8%.<\/jats:p>\n                  <jats:p>Discussion\/conclusion PRESERFLO MicroShunt implantation with adjunctive subconjunctival Healaflow\u00ae may provide a greater and more sustained IOP reduction and a lower medication burden than MicroShunt with mitomycin C alone, at least in the early-to-mid postoperative period and in the absence of postoperative 5-fluorouracil. Transient hypotony was more frequent but reversible. Further, prospective and standardized comparisons are warranted.<\/jats:p>","DOI":"10.1055\/a-2964-8392","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:28:18Z","timestamp":1791588498000},"source":"Crossref","is-referenced-by-count":0,"title":["Real-World Outcomes of PRESERFLO MicroShunt Implantations With and Without Adjunctive Healaflow\u00ae Application in Glaucoma Patients: A Single-Center Experience"],"prefix":"10.1055","author":[{"given":"Dominique Fr\u00e9d\u00e9ric","family":"Waldmann","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsspital Basel, Switzerland","place":["Basel"],"department":["Augenklinik"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3520-2791","authenticated-orcid":false,"given":"Konstantin","family":"Gugleta","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsspital Basel, Switzerland","place":["Basel"],"department":["Augenklinik"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Dervos","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsspital Basel, Switzerland","place":["Basel"],"department":["Augenklinik"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim J.","family":"Enz","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsspital Basel, Switzerland","place":["Basel"],"department":["Augenklinik"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oussama","family":"Habra","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsspital Basel, Switzerland","place":["Basel"],"department":["Augenklinik"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e0324806","DOI":"10.1371\/journal.pone.0324806","article-title":"Changes in individuals\u2019 glaucoma progression velocity after IOP-lowering therapy: a systematic review","volume":"20","author":"V Naik","year":"2025","journal-title":"PLoS One"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1002\/jbm.b.33525","article-title":"The development of a micro-shunt made from poly(styrene-block-isobutylene-block-styrene) to treat glaucoma","volume":"105","author":"L Pinchuk","year":"2017","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"8548","DOI":"10.3390\/jcm14238548","article-title":"Current challenges of managing fibrosis post glaucoma surgery and future 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Wang","year":"2018","journal-title":"Chin Med J"},{"key":"ref7","first-page":"9729","article-title":"The therapeutic effect of Healaflow in glaucoma surgery","volume":"13","author":"L Wu","year":"2021","journal-title":"Am J Transl Res"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"836269","DOI":"10.1155\/2015\/836269","article-title":"Trabeculectomy with Healaflow versus trabeculectomy for the treatment of glaucoma: a case-control study","volume":"2015","author":"D Papaconstantinou","year":"2015","journal-title":"J Ophthalmol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.4103\/ijo.IJO_2462_20","article-title":"Cross-linked hyaluronic acid viscoelastic scleral implant in trabeculectomy","volume":"69","author":"R Mudhol","year":"2021","journal-title":"Indian J Ophthalmol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"70","DOI":"10.5301\/ejo.5000054","article-title":"Crosslinked sodium hyaluronate implant in deep sclerectomy for the surgical treatment of glaucoma","volume":"22","author":"S Roy","year":"2012","journal-title":"Eur J Ophthalmol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"e625","DOI":"10.1097\/IJG.0000000000000309","article-title":"Deep sclerectomy with mitomycin C and injectable cross-linked hyaluronic acid implant: long-term results","volume":"25","author":"P Bettin","year":"2016","journal-title":"J Glaucoma"}],"container-title":["Klinische Monatsbl\u00e4tter f\u00fcr 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