{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:38:30Z","timestamp":1792625910956,"version":"4.5.0"},"reference-count":51,"publisher":"Georg Thieme Verlag KG","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pneumologie"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Extracorporeal membrane oxygenation (ECMO) is increasingly used as a bridging strategy\n        to lung transplantation. Long-term outcomes in this specific patient population after lung\n        transplantation remain incompletely described. We investigated age-dependent long-term\n        outcomes in adult lung transplant candidates on waiting list while receiving ECMO\n        support.<\/jats:p>\n                  <jats:p>We performed a retrospective single-center cohort study including all adult patients listed for lung transplantation while receiving ECMO support between November 2010 and May 2025. Patients were stratified a priori by age at listing (&lt;50 versus \u226550 years). The primary endpoint was 5-year post-transplant graft survival, defined as freedom from death or retransplantation. Secondary endpoints included comorbidities, frailty, exercise capacity, return to work, and patient-reported outcomes during outpatient follow-up.<\/jats:p>\n                  <jats:p>Among 1,493 patients listed for lung transplantation, 115 were listed while receiving\n        ECMO support; 72 patients were aged &lt;50 years and 43 patients were aged \u226550 years.\n        Overall, 93 ECMO-listed patients (81%) underwent transplantation. One-, three-, and\n        five-year post-transplant graft survival were 87%, 83%, and 77% in recipients aged &lt;50\n        years compared with 72%, 53%, and 44% in recipients aged \u226550 years, respectively.\n        Kaplan\u2013Meier analysis demonstrated a significant difference between age groups. Recipient\n        age \u226550 years was independently associated with an increased risk of graft loss in\n        multivariable analysis (adjusted HR 2.53, 95% CI 1.14\u20135.59; p=0.022). Among patients\n        reaching outpatient follow-up, older recipients had a slightly higher comorbidity burden,\n        reduced exercise capacity, and lower rates of return to work, while Clinical Frailty Scale\n        \u22654 remained relatively uncommon.<\/jats:p>\n                  <jats:p>In this 15-year single-center experience, recipient age \u226550 years was independently associated with inferior graft survival after ECMO-bridged lung transplantation. These findings support careful, function-oriented selection of older ECMO-supported candidates.<\/jats:p>","DOI":"10.1055\/a-2965-2500","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:51:55Z","timestamp":1792623115000},"source":"Crossref","is-referenced-by-count":0,"title":["Age-related Long-Term Outcomes after ECMO Bridging to Lung Transplantation: A 15-Year Single-Center Experience"],"prefix":"10.1055","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5123-4146","authenticated-orcid":false,"given":"Ole","family":"Zelmer","sequence":"additional","affiliation":[{"name":"Medizinische Hochschule Hannover, Deutschland","place":["Hannover"],"department":["Klinik f\u00fcr Pneumologie und Infektiologie"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Abu Isneineh","sequence":"additional","affiliation":[{"name":"Medizinische Hochschule Hannover, Deutschland","place":["Hannover"],"department":["Klinik f\u00fcr Gastroenterologie, Hepatologie, Infektiologie und Endokrinologie"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7373-752X","authenticated-orcid":false,"given":"Benjamin","family":"Seeliger","sequence":"additional","affiliation":[{"name":"Medizinische Hochschule Hannover, Deutschland","place":["Hannover"],"department":["Klinik f\u00fcr Pneumologie und Infektiologie"]},{"name":"Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Deutschland","place":["Hannover"],"department":["Member of the German Center for Lung Research (DZL)"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"K\u00fchn","sequence":"additional","affiliation":[{"name":"Medizinische Hochschule Hannover, Deutschland","place":["Hannover"],"department":["Klinik f\u00fcr Herz-, Thorax-, Transplantations- und Gef\u00e4\u00dfchirurgie"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8532-9427","authenticated-orcid":false,"given":"Susanne","family":"Simon","sequence":"additional","affiliation":[{"name":"Medizinische Hochschule Hannover, Deutschland","place":["Hannover"],"department":["Klinik f\u00fcr Pneumologie und Infektiologie"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9540-9022","authenticated-orcid":false,"given":"Jens","family":"Gottlieb","sequence":"additional","affiliation":[{"name":"Medizinische Hochschule Hannover, Deutschland","place":["Hannover"],"department":["Klinik f\u00fcr Pneumologie und Infektiologie"]},{"name":"Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Deutschland","place":["Hannover"],"department":["Member of the German Center for Lung Research (DZL)"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"4574","DOI":"10.21037\/jtd.2018.06.141","article-title":"Lung transplantation: indications and contraindications","volume":"10","author":"D Weill","year":"2018","journal-title":"J Thorac Dis"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.healun.2023.06.016","article-title":"Extracorporeal membrane oxygenation as a bridge to lung transplantation: Practice patterns and patient outcomes","volume":"43","author":"HJ Rando","year":"2024","journal-title":"J Heart Lung Transplant"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1016\/j.healun.2022.06.004","article-title":"Extracorporeal life support as a bridge to lung transplantation: Where are we now?","volume":"41","author":"CM Patterson","year":"2022","journal-title":"J Heart Lung 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Chang","year":"2018","journal-title":"Transplantation"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"e202","DOI":"10.1097\/tp.0000000000004052","article-title":"ECMO Long Haulers: A Distinct Phenotype of COVID-19-Associated ARDS With Implications for Lung Transplant Candidacy","volume":"106","author":"MR Mohanka","year":"2022","journal-title":"Transplantation"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s12890-023-02836-3","article-title":"Potential for recovery after extremely prolonged VV-ECMO support in well-selected severe COVID-19 patients: a retrospective cohort study","volume":"24","author":"JM de Walque","year":"2024","journal-title":"BMC Pulm Med"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.thorsurg.2014.09.010","article-title":"ECMO as bridge to lung transplant","volume":"25","author":"M Biscotti","year":"2015","journal-title":"Thorac Surg 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